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Chemical Compound Review:

Homarine 1-methylpyridine-6-carboxylate

Synonyms: SureCN272532, CHEBI:69061, NSC-714351, AC1Q5BFJ, NSC714351, ...

This record was replaced with 3621.

Nishina, Y. et al., Berking, S., Anthoni, U. et al., Howard, A.G. et al.

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High impact information on EINECS 223-025-0

The concentration of homarine in oocytes is about 25 mM [1].
During embryogenesis, metamorphosis and early colony development the overall homarine content does not change [1].
The analysis of the betaine homarine by high pressure liquid chromatography [2].
We investigated the mechanism of recognition and activation of substrate by D-amino acid oxidase (DAO) by thermodynamical and spectrophotometric methods using zwitterionic ligands [N-methylisonicotinate (NMIN), trigonelline, and homarine] and monoanionic ligands as model compounds of the substrate and the product [3].
In the isolated guinea-pig ileum assay, synergistic effects with other main components present (betaine, homarine) could not be demonstrated [4].

References

Homarine (N-methylpicolinic acid) and trigonelline (N-methylnicotinic acid) appear to be involved in pattern control in a marine hydroid. Berking, S. Development (1987) [Pubmed]
The analysis of the betaine homarine by high pressure liquid chromatography. Howard, A.G., Nickless, G. Anal. Biochem. (1976) [Pubmed]
Substrate recognition and activation mechanism of D-amino acid oxidase: a study using substrate analogs. Nishina, Y., Sato, K., Miura, R., Shiga, K. J. Biochem. (2000) [Pubmed]
The toxin tetramine from the "edible" whelk Neptunea antiqua. Anthoni, U., Bohlin, L., Larsen, C., Nielsen, P., Nielsen, N.H., Christophersen, C. Toxicon (1989) [Pubmed]

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