Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AGN-PC-00KGO5 [2-(11,17-dihydroxy-10,13- dimethyl-3-oxo-2...

Synonyms: SureCN13026148, AC1L1GDZ, AC-12502, CTK8G7286, STL301800, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on hydrocortisone acetate

HCA was orally administered to pregnant sows during three periods of gestation: 21-50 (period 1, P1, n = 10), 51-80 (period 2, P2, n = 10) and 81-110 (period 3, P3, n = 10) days after insemination (term 115 days) [1].
HCA was administered during three different periods of gestation (115 days in pigs): period 1: 21-50 (P1, n = 10), period 2: 51-80 (P2, n = 10) and period 3: 81-110 (P3, n = 10) days after insemination [2].
CONCLUSIONS AND CLINICAL RELEVANCE: Oral administration of 60 mg of HCA is suitable to increase plasma and salivary cortisol concentrations in pregnant sows in a controlled manner to concentrations comparable to concentrations detected after psychologic stressors [3].
The neutrophil-to-lymphocyte ratio was significantly higher in sows that received 180 mg of HCA [3].
The combined effects of cigarette smoke inhalation and hydrocortisone acetate (HCA) treatment induce prominent abnormalities in lungs of C57BL/6 male mice [4].

Biological context of hydrocortisone acetate

Gestation duration was significantly shorter in sows that received 180 mg of HCA [3].

Analytical, diagnostic and therapeutic context of hydrocortisone acetate

In the present study, oral administration of hydrocortisone-acetate (HCA) to 41 pregnant sows was used as a model for prenatal stress, since corticosteroids are considered a key mediator in the effects of prenatal stress [1].

References

Cortisol administration to pregnant sows affects novelty-induced locomotion, aggressive behaviour, and blunts gender differences in their offspring. Kranendonk, G., Hopster, H., Fillerup, M., Ekkel, E.D., Mulder, E.J., Taverne, M.A. Hormones and behavior. (2006) [Pubmed]
Lower birth weight and attenuated adrenocortical response to ACTH in offspring from sows that orally received cortisol during gestation. Kranendonk, G., Hopster, H., Fillerup, M., Ekkel, E.D., Mulder, E.J., Wiegant, V.M., Taverne, M.A. Domest. Anim. Endocrinol. (2006) [Pubmed]
Evaluation of oral administration of cortisol as a model for prenatal stress in pregnant sows. Kranendonk, G., Hopster, H., van Eerdenburg, F., van Reenen, K., Fillerup, M., de Groot, J., Korte, M., Taverne, M. Am. J. Vet. Res. (2005) [Pubmed]
Morphologic and physiologic response of lungs to steroid and cigarette smoke: an animal model. Matulionis, D.H., Kimmel, E., Diamond, L. Environmental research. (1985) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.