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Disease relevance of Insemination


Psychiatry related information on Insemination

  • METHODS: A total of 102 IVF families, 94 donor insemination (DI) families, 102 adoptive families, and 102 families with a naturally conceived child were compared on standardized interview and questionnaire measures of parenting and children's psychological well-being [6].

High impact information on Insemination

  • Adding TPA (100 nM) before insemination caused a reduction in the frequency of HRs at fertilization, but neither TPA nor sphingosine affected the frequency or size of HRs when they were added after the start of fertilization [7].
  • This decrease in fertility was associated with lower circulating concentrations of estradiol on the day of insemination, a decreased rate of increase in progesterone after insemination, and, ultimately, decreased circulating concentrations of progesterone [8].
  • Single injections of 3H-thymidine were performed between E12 and E15 (E0 is the day of insemination), and brains were examined at different postnatal ages between P1 and P63 [9].
  • These results support the hypothesis that the maturation-associated increase in the mass of IP(3)R-1 confers the increase in IP(3)-sensitivity that is observed following oocyte maturation and is necessary for the proper Ca(2+) oscillatory pattern following insemination [10].
  • Confocal imaging of eggs coinjected with lavendustin A and Oregon Green-dextran showed that the Ca2+ wave was inhibited under normal insemination conditions but that the block of the Ca2+ wave could be overcome with very high sperm densities [11].

Chemical compound and disease context of Insemination


Biological context of Insemination


Anatomical context of Insemination

  • In contrast, 2-cell embryos of B6C3F1 mice, which do not show a 2-cell block and develop normally to blastocysts in vitro, exhibit the dephosphorylation of p34cdc2 and an increase in histone H1 kinase activity between 31 and 45 hr after insemination [22].
  • Chlortetracycline staining has shown that frozen-thawed spermatozoa undergo an accelerated 'capacitation-like' process which has implications for their interaction with the female tract, ability to establish sperm reservoirs in vivo and hence for their life expectancy after insemination [23].
  • At least two cycles of IVF should be tried before reverting to other options such as insemination by donor sperm or gamete micromanipulation [24].
  • Embryos obtained from IVF were replaced into the uterus within 48 hours after insemination [25].
  • CONCLUSIONS: These results suggest that the DNA-synthetic, S-phase of the human zygote is initiated by approximately 9 to 10 hours after insemination and is completed approximately 3 to 5 hours later [26].

Associations of Insemination with chemical compounds


Gene context of Insemination

  • IGFBP-3 expression was higher in cows on day 0 and day 1 of the oestrous cycle than in heifers on day 3, day 6 and day 16 after insemination [31].
  • RESULTS: In blastomeres of cleaving embryos on the second and third days following insemination, E-cadherin was located in the cytoplasm--mostly concentrated in the cell margins [32].
  • The effects of ANP, caffeine and heparin on frozen-thawed sperm function were studied by insemination of porcine salt-stored oocytes in a modified Tris-buffered medium (mTBM) [33].
  • This is the first report of Y microdeletions in the Croatian population.Genetic counseling of all couples with the diagnosis of male infertility is recommended before intrauterine insemination, in vitro fertilization, and intracytoplasmic sperm injection, and should also include AZF and CFTR genotyping [34].
  • After the insemination, the expression of AIF-1 mRNA diminished gradually and again increased in the pre-implantation or implantation period in allogeneic or syngeneic pregnancy, respectively [35].

Analytical, diagnostic and therapeutic context of Insemination


  1. Genetics and human reproduction. McLaren, A. Trends Genet. (1998) [Pubmed]
  2. Interaction of seminal plasma proteins with cell surface antigens: presence of a CD4-binding glycoprotein in human seminal plasma. Autiero, M., Abrescia, P., Guardiola, J. Exp. Cell Res. (1991) [Pubmed]
  3. Intracytoplasmic sperm injection versus in vitro fertilization: a randomized controlled trial and a meta-analysis of the literature. Tournaye, H., Verheyen, G., Albano, C., Camus, M., Van Landuyt, L., Devroey, P., Van Steirteghem, A. Fertil. Steril. (2002) [Pubmed]
  4. Reversible infertility in a man with 21-hydroxylase deficiency congenital adrenal hyperplasia. Yang, R.M., Fefferman, R.A., Shapiro, C.E. Fertil. Steril. (2005) [Pubmed]
  5. Anaphylactic reaction after artificial insemination. Orta, M., Ordoqui, E., Aranzábal, A., Fernández, C., Bartolomé, B., Sanz, M.L. Ann. Allergy Asthma Immunol. (2003) [Pubmed]
  6. The European study of assisted reproduction families: the transition to adolescence. Golombok, S., Brewaeys, A., Giavazzi, M.T., Guerra, D., MacCallum, F., Rust, J. Hum. Reprod. (2002) [Pubmed]
  7. Evidence for an inhibitory effect of protein kinase C on G-protein-mediated repetitive calcium transients in hamster eggs. Swann, K., Igusa, Y., Miyazaki, S. EMBO J. (1989) [Pubmed]
  8. Relationship between follicle size at insemination and pregnancy success. Perry, G.A., Smith, M.F., Lucy, M.C., Green, J.A., Parks, T.E., MacNeil, M.D., Roberts, A.J., Geary, T.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Persistence of early-generated neurons in the rodent subplate: assessment of cell death in neocortex during the early postnatal period. Valverde, F., López-Mascaraque, L., Santacana, M., De Carlos, J.A. J. Neurosci. (1995) [Pubmed]
  10. Maturation-associated increase in IP3 receptor type 1: role in conferring increased IP3 sensitivity and Ca2+ oscillatory behavior in mouse eggs. Xu, Z., Williams, C.J., Kopf, G.S., Schultz, R.M. Dev. Biol. (2003) [Pubmed]
  11. Tyrosine kinase inhibitors block sperm-induced egg activation in Xenopus laevis. Glahn, D., Mark, S.D., Behr, R.K., Nuccitelli, R. Dev. Biol. (1999) [Pubmed]
  12. Intrauterine insemination does and clomiphene citrate does not improve fecundity in couples with infertility due to male or idiopathic factors: a prospective, randomized, controlled study. Martinez, A.R., Bernardus, R.E., Voorhorst, F.J., Vermeiden, J.P., Schoemaker, J. Fertil. Steril. (1990) [Pubmed]
  13. Effect of pretreatment with bovine somatotropin (bST) and/or gonadotropin-releasing hormone (GnRH) on conception rate of dairy cows with ovarian cysts subjected to synchronization of ovulation and timed insemination. Bartolome, J., Hernandez, J., Sheerin, P., Luznar, S., Kelbert, D., Thatcher, W.W., Archbald, L.F. Theriogenology (2003) [Pubmed]
  14. Effect of vulvomucosal injection of D-cloprostenol at weaning and at insemination on reproductive performance of sows during the low fertility summer season under field conditions. Peña, F.J., Gil, M.C., Peña, F. Anim. Reprod. Sci. (2001) [Pubmed]
  15. Effects of timed insemination and supplemental beta-carotene on reproduction and milk yield of dairy cows under heat stress. Aréchiga, C.F., Staples, C.R., McDowell, L.R., Hansen, P.J. J. Dairy Sci. (1998) [Pubmed]
  16. Methoprene affects the rotation of the male terminalia of Aedes aegypti mosquitoes. O'Donnell, P.P., Klowden, M.J. J. Am. Mosq. Control Assoc. (1997) [Pubmed]
  17. Fertility differences among male rabbits determined by heterospermic insemination of fluorochrome-labeled spermatozoa. Parrish, J.J., Foote, R.H. Biol. Reprod. (1985) [Pubmed]
  18. Characterization of human sperm surface antigens with monoclonal antibodies. Wolf, D.P., Sokoloski, J.E., Dandekar, P., Bechtol, K.B. Biol. Reprod. (1983) [Pubmed]
  19. Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation. Huo, L.J., Fan, H.Y., Zhong, Z.S., Chen, D.Y., Schatten, H., Sun, Q.Y. Mech. Dev. (2004) [Pubmed]
  20. Cortisol administration to pregnant sows affects novelty-induced locomotion, aggressive behaviour, and blunts gender differences in their offspring. Kranendonk, G., Hopster, H., Fillerup, M., Ekkel, E.D., Mulder, E.J., Taverne, M.A. Hormones and behavior. (2006) [Pubmed]
  21. Effects of letrozole on superovulation with gonadotropins in women undergoing intrauterine insemination. Healey, S., Tan, S.L., Tulandi, T., Biljan, M.M. Fertil. Steril. (2003) [Pubmed]
  22. A deficiency in the mechanism for p34cdc2 protein kinase activation in mouse embryos arrested at 2-cell stage. Aoki, F., Choi, T., Mori, M., Yamashita, M., Nagahama, Y., Kohmoto, K. Dev. Biol. (1992) [Pubmed]
  23. Cryopreservation of semen from domestic livestock. Curry, M.R. Rev. Reprod. (2000) [Pubmed]
  24. Failure to fertilize in vitro in couples with male factor infertility: what next? Ben-Shlomo, I., Bider, D., Dor, J., Levran, D., Mashiach, S., Ben-Rafael, Z. Fertil. Steril. (1992) [Pubmed]
  25. Serum is more effective than albumin in promoting human embryo development and implantation. Hargreaves, C.A., Rahman, F., Cowan, D., Santis, M., Keefe, T., Howell, R.J., Chard, T., Homa, S.T. Fertil. Steril. (1995) [Pubmed]
  26. Characterization of the first cell cycle in human zygotes: implications for cryopreservation. Balakier, H., MacLusky, N.J., Casper, R.F. Fertil. Steril. (1993) [Pubmed]
  27. Sperm nuclear transformations consist of enlargement and condensation coordinate with stages of meiotic maturation in fertilized Spisula solidissima oocytes. Luttmer, S.J., Longo, F.J. Dev. Biol. (1988) [Pubmed]
  28. The effects of several ion channel blockers and calmodulin antagonists on fertilization-induced acid release and 45Ca2+ uptake in sea urchin eggs. Komukai, M., Fujiwara, A., Fujino, Y., Yasumasu, I. Exp. Cell Res. (1985) [Pubmed]
  29. The importance of a luteolytic effect of the pituitary in understanding the placental control of the rat corpus luteum. Ochiai, K., Kato, H., Kelly, P.A., Rothchild, I. Endocrinology (1983) [Pubmed]
  30. Autocrine mediators are required to act on the embryo by the 2-cell stage to promote normal development and survival of mouse preimplantation embryos in vitro. O'Neill, C. Biol. Reprod. (1998) [Pubmed]
  31. Expression of the insulin-like growth factor (IGF) system in the bovine oviduct at oestrus and during early pregnancy. Pushpakumara, P.G., Robinson, R.S., Demmers, K.J., Mann, G.E., Sinclair, K.D., Webb, R., Wathes, D.C. Reproduction (2002) [Pubmed]
  32. Epithelial cadherin distribution in abnormal human pre-implantation embryos. Alikani, M. Hum. Reprod. (2005) [Pubmed]
  33. Atrial natriuretic peptide induces an acrosome reaction in giant panda spermatozoa and enhances their penetration of salt-stored porcine oocytes. Zhang, M., Tang, H., Shen, G., Zhou, B., Wu, Z., Peng, Z., Zhang, J., Yan, J., Xia, G. Theriogenology (2005) [Pubmed]
  34. Genetic markers of male infertility: Y chromosome microdeletions and cystic fibrosis transmembrane conductance gene mutations. Sertić, J., Cvitković, P., Myers, A., Saiki, R.K., Stavljenić Rukavina, A. Croat. Med. J. (2001) [Pubmed]
  35. Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption. Shimada, S., Iwabuchi, K., Watano, K., Shimizu, H., Yamada, H., Minakami, H., Onoé, K. Am. J. Reprod. Immunol. (2003) [Pubmed]
  36. Fertilization rates using intracytoplasmic sperm injection are greater than subzonal insemination but are dependent on prior treatment of sperm. Catt, J., Ryan, J., Pike, I., O'Neill, C. Fertil. Steril. (1995) [Pubmed]
  37. Treatment of endometriosis-associated infertility. Adamson, G.D. Semin. Reprod. Endocrinol. (1997) [Pubmed]
  38. Sperm transport after non-surgical intrauterine insemination with frozen semen in ewes treated with prostaglandin F-2alpha. Fukui, Y., Roberts, E.M. J. Reprod. Fertil. (1977) [Pubmed]
  39. Selective use of leuprolide acetate in women undergoing superovulation with intrauterine insemination results in significant improvement in pregnancy outcome. Manzi, D.L., Dumez, S., Scott, L.B., Nulsen, J.C. Fertil. Steril. (1995) [Pubmed]
  40. The accuracy of urinary luteinizing hormone testing in predicting ovulation. Lloyd, R., Coulam, C.B. Am. J. Obstet. Gynecol. (1989) [Pubmed]
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