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Chemical Compound Review:

CARTAZOLATE ethyl 2-butylamino-7-ethyl-5,7,8...

Synonyms: Cartazolato, Cartazolatum, CHEMBL8184, SureCN123839, CHEBI:103142, ...

Placheta, P. et al., Kripalani, K.J. et al.

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High impact information on SQ 65396

In vitro modulation by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes [1].
Biotransformation in the monkey of cartazolate (SQ 65,396), a substituted pyrazolopyridine having anxiolytic activity [2].

Anatomical context of SQ 65396

SQ 20009 and SQ 65396, two new pyrazolopyridines with anxiolytic properties in animals, reversibly increased Na+-independent 3H-GABA binding to rat cerabral cortex membranes in vitro [1].

Analytical, diagnostic and therapeutic context of SQ 65396

1. The metabolism of cartazolate (SQ 65,396), an anxiolytic agent, was studied in four male rhesus monkeys after oral administration [2].

References

In vitro modulation by SQ 20009 and SQ 65396 of GABA receptor binding in rat CNS membranes. Placheta, P., Karobath, M. Eur. J. Pharmacol. (1980) [Pubmed]
Biotransformation in the monkey of cartazolate (SQ 65,396), a substituted pyrazolopyridine having anxiolytic activity. Kripalani, K.J., Dreyfuss, J., Nemec, J., Cohen, A.I., Meeker, F., Egli, P. Xenobiotica (1981) [Pubmed]

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