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Chemical Compound Review

CHEMBL89852     benzyl ethyl 2-methyl-6-phenyl-4-(2...

Synonyms: MRS-1191, SureCN3741774, MRS1191, CHEBI:241567, NSC-695673, ...
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Disease relevance of MRS1191

  • The adenosine A3 receptor-selective antagonist 3-ethyl 5-benzyl-2-methyl-6-phenyl-4-phenylethynyl-1, 4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS1191) caused a biphasic inhibition of the protective effect of the brief ischemia [1].
  • The addition of the A3 adenosine receptor (A3AR) antagonist 3-ethyl-5-benzyl-2-methyl-4-phenylethyl-6-phenyl-1,4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS1191, 100 nM ) to the combined antagonists further attenuated vasodilator responses to APNEA [2].

High impact information on MRS1191


  1. A physiological role of the adenosine A3 receptor: sustained cardioprotection. Liang, B.T., Jacobson, K.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. Hinschen, A.K., Rose'Meyer, R.B., Headrick, J.P. J. Cardiovasc. Pharmacol. (2003) [Pubmed]
  3. Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells. Hoskin, D.W., Butler, J.J., Drapeau, D., Haeryfar, S.M., Blay, J. Int. J. Cancer (2002) [Pubmed]
  4. Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel. Zhao, T.C., Kukreja, R.C. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  5. Activation of the A3 adenosine receptor affects cell cycle progression and cell growth. Brambilla, R., Cattabeni, F., Ceruti, S., Barbieri, D., Franceschi, C., Kim, Y.C., Jacobson, K.A., Klotz, K.N., Lohse, M.J., Abbracchio, M.P. Naunyn Schmiedebergs Arch. Pharmacol. (2000) [Pubmed]
  6. Adenosine A(3) receptor mediated coronary vasodilation in the rat heart: changes that occur with maturation. Jenner, T.L., Rose'meyer, R.B. Mech. Ageing Dev. (2006) [Pubmed]
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