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Chemical Compound Review

DMPX     3,7-dimethyl-1-prop-2-ynyl- purine-2,6-dione

Synonyms: Lopac-D-134, CHEMBL282038, D134_SIGMA, AG-L-63646, ANW-57638, ...
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Disease relevance of DMPX


Psychiatry related information on DMPX


High impact information on DMPX


Biological context of DMPX


Anatomical context of DMPX


Associations of DMPX with other chemical compounds


Gene context of DMPX

  • In contrast, the selective A1AR agonist, chloro-N6-cyclopentyladenosine (CCPA) and the A2AR antagonist, 3,7-dimethyl-1-propargylxanthine (DMPX) enhanced each stimulant-induced TF activity expression [19].
  • However, in oxidized cells, when DPCPX was tested together with CPA 100 nM the total release of D-[3H]aspartate increased from 5.1 +/- 0.4% to 11.4 +/- 1.0%, this increase being reverted by 3,7-dimethyl-1-propargylxanthine (DMPX; 100 nM), an antagonist of A2A adenosine receptors [20].
  • The action of CGS-21680 was mediated via the A2 receptors since its effect on TNF production was blocked by 3,7-dimethyl-1-propargylxanthine (DMPX) but not by xanthine amine cogener (XAC), antagonists selective for the A2 and A1 receptors, respectively [21].


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  7. Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. Müller, C.E., Geis, U., Hipp, J., Schobert, U., Frobenius, W., Pawłowski, M., Suzuki, F., Sandoval-Ramírez, J. J. Med. Chem. (1997) [Pubmed]
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  14. The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. Gadangi, P., Longaker, M., Naime, D., Levin, R.I., Recht, P.A., Montesinos, M.C., Buckley, M.T., Carlin, G., Cronstein, B.N. J. Immunol. (1996) [Pubmed]
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  17. The effect of anoxia on cardiomyocyte glucose transport does not involve an adenosine release or a change in energy state. Eblenkamp, M., Böttcher, U., Thomas, J., Löken, C., Ionescu, I., Rose, H., Kammermeier, H., Fischer, Y. Life Sci. (1996) [Pubmed]
  18. Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. Alfinito, P.D., Wang, S.P., Manzino, L., Rijhsinghani, S., Zeevalk, G.D., Sonsalla, P.K. J. Neurosci. (2003) [Pubmed]
  19. Adenosine regulates tissue factor expression on endothelial cells. Deguchi, H., Takeya, H., Urano, H., Gabazza, E.C., Zhou, H., Suzuki, K. Thromb. Res. (1998) [Pubmed]
  20. Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress. Agostinho, P., Caseiro, P., Rego, A.C., Duarte, E.P., Cunha, R.A., Oliveira, C.R. Neurochem. Int. (2000) [Pubmed]
  21. Inhibition of LPS-induced TNF alpha production in human monocytes by adenosine (A2) receptor selective agonists. Prabhakar, U., Brooks, D.P., Lipshlitz, D., Esser, K.M. Int. J. Immunopharmacol. (1995) [Pubmed]
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