Chemical Compound Review:
DMPX 3,7-dimethyl-1-prop-2-ynyl- purine-2,6-dione
Synonyms:
Lopac-D-134, CHEMBL282038, D134_SIGMA, AG-L-63646, ANW-57638, ...
- Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. Okada, M., Kawata, Y., Kiryu, K., Mizuno, K., Wada, K., Tasaki, H., Kaneko, S. J. Neurochem. (1997)
- Hypoglycemia selectively abolishes hypoxic reactivity of pial arterioles in piglets: role of adenosine. Park, T.S., Gonzales, E.R., Shah, A.R., Gidday, J.M. Am. J. Physiol. (1995)
- The intrastratial injection of an adenosine A(2) receptor antagonist prevents frontal cortex EEG abnormalities in a rat model of Huntington's disease. Reggio, R., Pèzzola, A., Popoli, P. Brain Res. (1999)
- The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. Cronstein, B.N., Naime, D., Ostad, E. J. Clin. Invest. (1993)
- Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Merrill, J.T., Shen, C., Schreibman, D., Coffey, D., Zakharenko, O., Fisher, R., Lahita, R.G., Salmon, J., Cronstein, B.N. Arthritis Rheum. (1997)
- In vivo effects of adenosine A(2) receptor agonist and antagonist on neuronal and astrocytic intermediary metabolism studied with ex vivo (13)C MR spectroscopy. Hammer, J., Qu, H., Håberg, A., Sonnewald, U. J. Neurochem. (2001)
- Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. Müller, C.E., Geis, U., Hipp, J., Schobert, U., Frobenius, W., Pawłowski, M., Suzuki, F., Sandoval-Ramírez, J. J. Med. Chem. (1997)
- Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Sato, A., Terata, K., Miura, H., Toyama, K., Loberiza, F.R., Hatoum, O.A., Saito, T., Sakuma, I., Gutterman, D.D. Am. J. Physiol. Heart Circ. Physiol. (2005)
- Differential effects of diadenosine phosphates on purinoceptors in the rat isolated perfused kidney. van der Giet, M., Khattab, M., Börgel, J., Schlüter, H., Zidek, W. Br. J. Pharmacol. (1997)
- A role for adenosine A2 receptors in the induction of long-term potentiation in the CA1 region of rat hippocampus. Kessey, K., Trommer, B.L., Overstreet, L.S., Ji, T., Mogul, D.J. Brain Res. (1997)
- Effects of CGS 21680 in vivo on dopamine D2 agonist binding in the rat brain. Hillefors-Berglund, M., Hedlund, P.B., von Euler, G. Brain Res. (1995)
- Modulation of vasopressin actions on human platelets by plasma adenosine and theophylline: gender differences. Agarwal, K.C. J. Cardiovasc. Pharmacol. (1993)
- Roles of adenosine receptors in the regulation of kainic acid-induced neurotoxic responses in mice. Lee, H.K., Choi, S.S., Han, K.J., Han, E.J., Suh, H.W. Brain Res. Mol. Brain Res. (2004)
- The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. Gadangi, P., Longaker, M., Naime, D., Levin, R.I., Recht, P.A., Montesinos, M.C., Buckley, M.T., Carlin, G., Cronstein, B.N. J. Immunol. (1996)
- Vasodilatation produced by adenosine in isolated rat perfused mesenteric artery: a role for endothelium. Tabrizchi, R., Lupichuk, S.M. Naunyn Schmiedebergs Arch. Pharmacol. (1995)
- Adenosine as an endogenous mediator of hypoxia for induction of vascular endothelial growth factor mRNA in U-937 cells. Hashimoto, E., Kage, K., Ogita, T., Nakaoka, T., Matsuoka, R., Kira, Y. Biochem. Biophys. Res. Commun. (1994)
- The effect of anoxia on cardiomyocyte glucose transport does not involve an adenosine release or a change in energy state. Eblenkamp, M., Böttcher, U., Thomas, J., Löken, C., Ionescu, I., Rose, H., Kammermeier, H., Fischer, Y. Life Sci. (1996)
- Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. Alfinito, P.D., Wang, S.P., Manzino, L., Rijhsinghani, S., Zeevalk, G.D., Sonsalla, P.K. J. Neurosci. (2003)
- Adenosine regulates tissue factor expression on endothelial cells. Deguchi, H., Takeya, H., Urano, H., Gabazza, E.C., Zhou, H., Suzuki, K. Thromb. Res. (1998)
- Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress. Agostinho, P., Caseiro, P., Rego, A.C., Duarte, E.P., Cunha, R.A., Oliveira, C.R. Neurochem. Int. (2000)
- Inhibition of LPS-induced TNF alpha production in human monocytes by adenosine (A2) receptor selective agonists. Prabhakar, U., Brooks, D.P., Lipshlitz, D., Esser, K.M. Int. J. Immunopharmacol. (1995)