Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Epofenonane 2-ethyl-3-[3-ethyl-5-(4...

Synonyms: CTK8J4085, AC1L27GV, 57342-02-6, EINECS 260-685-9, Epofenonane [ISO]

Oda, S. et al., Krämer, B. et al., Oda, S. et al., Wroblewski, V.J. et al.

Oda, Tatarazako, Watanabe, Morita, Iguchi, Oda, Tatarazako, Watanabe, Morita, Iguchi,

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High impact information on Epofenonane

Down-regulation of expression of a pupal cuticle protein gene (GmPCP52) was investigated during metamorphosis in Galleria during normal development and in response to 20-hydroxyecdysone (20 E) and a juvenile hormone analogue (epofenonane) [1].
Treatment of L5D2 larvae with the juvenile hormone mimic epofenonane resulted in a 7- and 14-fold increase in the level of JHE mRNA in the integument and fat body, respectively [2].
Epofenonane did not decrease reproduction in the NIES and Belgium A strains as dramatically as did fenoxycarb, but the neonatal sex ratio changed in a concentration-dependent manner [3].
EC50 values for production of male neonates were estimated as 400 (JH I), 410 (JH II), 190 (kinoprene), 2.9 (hydroprene), 64 (epofenonane), and 0.92 (fenoxycarb) microg/l. The number of neonates produced was reduced with all chemicals at the concentrations investigated [4].

References

Down-regulation of expression of a pupal cuticle protein gene by transcriptional and posttranscriptional control mechanisms during metamorphosis in Galleria. Krämer, B., Wolbert, P. Dev. Genes Evol. (1998) [Pubmed]
Regulation of juvenile hormone esterase gene expression in the tobacco budworm (Heliothis virescens). Wroblewski, V.J., Harshman, L.G., Hanzlik, T.N., Hammock, B.D. Arch. Biochem. Biophys. (1990) [Pubmed]
Genetic differences in the production of male neonates in Daphnia magna exposed to juvenile hormone analogs. Oda, S., Tatarazako, N., Watanabe, H., Morita, M., Iguchi, T. Chemosphere (2006) [Pubmed]
Production of male neonates in Daphnia magna (Cladocera, Crustacea) exposed to juvenile hormones and their analogs. Oda, S., Tatarazako, N., Watanabe, H., Morita, M., Iguchi, T. Chemosphere (2005) [Pubmed]

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