Disease relevance of Altozar

• Hydroprene had a significantly lower SD50 (dose required to sterilize 50% of the cockroaches) for males (39.82 micrograms/g body weight) compared with females (86.64 micrograms/g body weight) [1].
• The temperature toxicity relation shape of the three compounds and five insect growth regulations (methoprene, hydroprene, teflubenzuron, chlorfluazuron and Precocene I) alone or in combination against P. dux was studied and discussed [2].

Psychiatry related information on Altozar

• This study provides morphological evidence that B. orientalis with malformed genitalia after treatment with hydroprene would be unsuccessful in copulation and fertilization [3].

High impact information on Altozar

• At high concentrations the (+) isomer and mixed isomer preparations of methoprene and hydroprene competed for binding sites [4].
• Methoprene (isopropyl [2E,4E]-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate) and hydroprene (ethyl[2E,4E]-3,7,11-trimethyldodeca-2,4-dienoate) are actively metabolized, mainly to their corresponding acids by isolated rat hepatocytes and rat liver subcellular fractions [5].
• Methoprene and hydroprene are metabolized by ester cleavage in isolated hepatocytes [5].
• Manipulations of the glands' hormonal milieu showed that hsc 70 mRNA levels respond to 20-hydroxyecdysone, dibutyryl cAMP, PTTH and the JH analogue hydroprene [6].
• Structure-activity relationship of a series of new diphenylethers was analyzed and compared to juvenoids like methoprene, hydroprene, and fenoxycarb [7].

Biological context of Altozar

• Altozar treatments on the fifth day of feeding, shortly before oviposition, and especially immediately after detachment (points 4, 5 and 6, respectively) mainly resulted in non-viability of the eggs [8].
• Hydroprene had a considerable effect on the morphogenesis of external genitalia of the oriental cockroach, Blatta orientalis L [3].

Anatomical context of Altozar

• Exposure of nymphs to hydroprene resulted in abnormal adultoids with structural and positional distortions, and reduced or absent cuticular sclerotizations of the external genitalia [3].
• A high correlation between wrinkled wings and malformed male genitalia can be an important criterion to evaluate the effects of hydroprene on this species [3].
• In males, the epithelial cells of wings, serrata of the right phallomere, titillator and other lobes of the left phallomere were sensitive to hydroprene [3].

Associations of Altozar with other chemical compounds

• Ixodes persulcatus females were treated with Altozar and DDT at one of six consecutive time-points during the period beginning with attachment and ending with the commencement of oviposition [8].
• The sensitive developmental period of last-instar German cockroaches, Blattella germanica (L.), to topical applications (10 micrograms/microliters) of fenoxycarb and hydroprene was determined [9].

Gene context of Altozar

• Cockroaches treated with 100 micrograms/microliters of hydroprene lived 10-14 wk fewer than control adults and often attempted a sixth (supernumerary) molt [1].

Analytical, diagnostic and therapeutic context of Altozar

• Altozar effects after treatment at points 1-3 may be considered to be hormonal [8].
• Methoprene was more effective than hydroprene in diet-incorporation bioassays and was slightly more effective for the first 30 d of the contact assays [10].

References