Disease relevance of Pictyl

• Several compounds, structurally related to the insect growth regulator Fenoxycarb, exhibited interesting inhibition action to control proliferation of Trypanosoma cruzi, the parasite responsible for Chagas' disease [1].
• However, limited food significantly decreased the toxicity of fenoxycarb, and significantly increased the toxicity of chlorpyrifos [2].
• In a study examining three application rates for fenoxycarb, new interpretations of population age structure in relation to sterility levels and population reductions were used to establish important concepts in the management of German cockroaches, Blattella germanica (L.), with juvenoids [3].
• Female sterility was complete at 100 ppm of pyriproxyfen and fenoxycarb [4].
• In contrast, SD50's of fenoxycarb did not differ significantly between the sexes (18.04 and 13.66 micrograms/g body weight for females and males) and were significantly lower when compared with SD50's of hydroprene [5].

High impact information on Pictyl

• JH agonists, pyriproxyfen and fenoxycarb, strongly repressed the expression of VTG genes in neonate daphnids [6].
• On the other hand, the inhibitory action of JH-III, methoprene and fenoxycarb was an unspecific effect according to the results obtained with Leishmania mexicana mexicana (promastigotes) and human peripheral blood lymphocytes [7].
• Epofenonane did not decrease reproduction in the NIES and Belgium A strains as dramatically as did fenoxycarb, but the neonatal sex ratio changed in a concentration-dependent manner [8].
• We exposed the water flea Daphnia magna (Cladocera, Crustacea) to either juvenile hormone I (JH I), juvenile hormone II (JH II), or the juvenile hormone-mimicking insecticides kinoprene, hydroprene, epofenonane, or fenoxycarb [9].
• In a previous study we showed that juvenile hormone (JH) or its analog, fenoxycarb (FX), is involved in the up-regulation of pheromone biosynthesis-activating neuropeptide (PBAN) competence [10].

Biological context of Pictyl

• A fenoxycarb concentration of 888 microg L(-1) significantly (p < 0.05) inhibited embryonic development to larval hatching and extended the embryonic developmental period from 11.9 to 12.7 days [11].
• Starvation before fenoxycarb treatment strongly enhanced the incidence of extra molting up to 100% [12].
• However, in such female pupae specific binding of the 50 kD protein by the photoaffinity-biotin labelled PBAN analog was induced after JH II or FX treatments thereby providing evidence that JH may up-regulate this putative receptor protein [13].
• No clinical signs associated with exposure to fenoxycarb were observed in any animal at any time, and no exposure-related pattern of pathologic lesions or reproductive organ histology was observed [14].
• Effects of the carbamates fenoxycarb, propamocarb and propoxur on energy supply, glucose utilization and SH-groups in neurons [15].

Anatomical context of Pictyl

• No fenoxycarb was detected in any lamb liver at 28 days, although both the colostrum and the milk of exposed ewes were found to contain fenoxycarb at levels proportional to the treatments [14].
• Fenoxycarb and thyroid hormones have JH-like effects on the follicle cells of Locusta migratoria in vitro [16].
• Fenoxycarb exhibited embryocidal activity against eggs in early blastoderm formation, blastokinesis, and advanced larval development up to hatching [17].

Associations of Pictyl with other chemical compounds

• Earlier work demonstrated that phenoxy-phenyl compounds such as fenoxycarb and thyroxine mimicked the effects of JH III in causing a reduction in volume of the follicle cells of Locusta migratoria [18].
• The juvenoid fenoxycarb, a phenoxyphenyl derivative, is unrelated in structure to the juvenile hormones (which are derivatives of farnesoic acid), but it also caused a reduction in volume of the cells in vitro as measured by an increase in the optical path difference [16].
• Sensitive developmental period of last-instar German cockroaches (Dictyoptera: Blattelidae) to fenoxycarb and hydroprene [19].
• Late-instar German cockroaches, Blattella germanica (L.), were used to evaluate the relative effects of single treatments and combinations of three insect growth regulators (IGRs): pyriproxyfen, fenoxycarb, and diflubenzuron [4].
• In the field, applications of house fly pupae and eye gnat, Hippelates pusio Loew, pupae dipped in acetone solutions of fenoxycarb significantly reduced population indices of the red imported fire ant, S. invicta, compared with commercial formulations of fenoxycarb (Logic) and hydramethylnon (Amdro) [20].

Gene context of Pictyl

• The effects of the juvenile hormone analog fenoxycarb (CAS No. 72490-01-8) were investigated in artificial indoor streams [21].

Analytical, diagnostic and therapeutic context of Pictyl

• Sensitive and selective enzyme-linked immunosorbent assays (ELISAs) in the immobilized antigen format were developed for fenoxycarb (1), an insect growth regulator (IGR) [22].
• Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb [22].
• Evaluation of an enzyme immunoassay for the detection of the insect growth regulator fenoxycarb in environmental and biological samples [23].
• The number of queens that successfully mated and laid eggs was affected in the fenoxycarb treatment group but there were no significant differences in the drone sperm counts between the colonies [24].
• Absence of ovicidal effects of fenoxycarb in the tick Ixodes dammini as observed by light, scanning, and transmission electron microscopy [25].

References