Disease relevance of C00666

• In E. coli, dapE encodes N-succinyl-L-diaminopimelic acid desuccinylase, which catalyzes the hydrolysis of N-succinyl-L-diaminopimelic acid to L-diaminopimelic acid (L-DAP) and succinate [1].
• The L-diaminopimelic acid isomer was detected in all 10 strains of Streptomyces tested, and the meso-diaminopimelic acid isomer was detected in all 10 strains of Nocardia tested [2].
• Comparative sequence analyses of the ribonuclease P (RNase P) RNA genes from LL-2,6-diaminopimelic acid-containing actinomycetes [3].

High impact information on C00666

• The enzyme is part of the diaminopimelic acid-lysine pathway in bacteria and catalyzes the hydrolysis of N-succinyl-L-diaminopimelic acid to produce L-diaminopimelic acid and succinate [4].
• The isolate was characterized chemotaxonomically as having ll-2,6-diaminopimelic acid in the cell-wall peptidoglycan, MK-9(H(4)) as the predominant menaquinone and anteiso-C(15 : 0), iso-C(15 : 0) and iso-C(16 : 0) as the major fatty acids [5].

Anatomical context of C00666

• Chemotaxonomically, it contained ll-2,6-diaminopimelic acid in the cell wall [6].

Associations of C00666 with other chemical compounds

• The chemotaxonomic properties of strain DS-51(T) were consistent with those of the genus Nocardioides: the cell-wall peptidoglycan type was based on ll-2,6-diaminopimelic acid, MK-8(H(4)) was the predominant menaquinone and iso-C(16 : 0) was the major fatty acid [7].

References