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Chemical Compound Review:

D-Leucate (2R)-2-hydroxy-4-methyl- pentanoic acid

Synonyms: delta-Leucate, D-leucic acid, AG-E-48844, CHEBI:55534, HMDB00624, ...

Taguchi, H. et al., Bernard, N. et al., Kochhar, S. et al., Aitken, S.M. et al., Niefind, K. et al.

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Disease relevance of D-2-Hydroxyisocaproate

In contrast, the D-lactate dehydrogenase is homologous to E. coli D-3-phosphoglycerate dehydrogenase and Lactobacillus casei D-2-hydroxyisocaproate dehydrogenase [1].

High impact information on D-2-Hydroxyisocaproate

Novel continuous assays for the elimination reaction, employing D-2-hydroxyisocaproate dehydrogenase, and for the substitution reaction, employing cystathionine beta-lyase and L-lactate dehydrogenase as coupling enzymes, are described [2].
The deduced amino acid sequence of the encoded enzyme indicates a 333-residue protein closely related to D-2-hydroxyisocaproate (i.e. 2-hydroxy-4-methyl-pentanoate) dehydrogenase (D-HO-HxoDH) of Lactobacillus casei and other NAD(+)-dependent D-lactate dehydrogenases (D-LDH) from several other bacterial species [3].
However, D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, glycerate dehydrogenase from cucumber, D-3-phosphoglycerate dehydrogenase and erythronate 4-phosphate dehydrogenase from Escherichia coli showed 38%, 24%, 24% and 22% amino acid identity, respectively [4].

Analytical, diagnostic and therapeutic context of D-2-Hydroxyisocaproate

Crystallization and preliminary characterization of crystals of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei [5].

References

D-lactate dehydrogenase is a member of the D-isomer-specific 2-hydroxyacid dehydrogenase family. Cloning, sequencing, and expression in Escherichia coli of the D-lactate dehydrogenase gene of Lactobacillus plantarum. Taguchi, H., Ohta, T. J. Biol. Chem. (1991) [Pubmed]
Escherichia coli cystathionine gamma-synthase does not obey ping-pong kinetics. Novel continuous assays for the elimination and substitution reactions. Aitken, S.M., Kim, D.H., Kirsch, J.F. Biochemistry (2003) [Pubmed]
NAD(+)-dependent D-2-hydroxyisocaproate dehydrogenase of Lactobacillus delbrueckii subsp. bulgaricus. Gene cloning and enzyme characterization. Bernard, N., Johnsen, K., Ferain, T., Garmyn, D., Hols, P., Holbrook, J.J., Delcour, J. Eur. J. Biochem. (1994) [Pubmed]
Evolutionary relationship of NAD(+)-dependent D-lactate dehydrogenase: comparison of primary structure of 2-hydroxy acid dehydrogenases. Kochhar, S., Hunziker, P.E., Leong-Morgenthaler, P., Hottinger, H. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
Crystallization and preliminary characterization of crystals of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei. Niefind, K., Hecht, H.J., Schomburg, D. J. Mol. Biol. (1994) [Pubmed]

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