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Gene Review

pdxB  -  erythronate-4-phosphate dehydrogenase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2314, JW2317
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Disease relevance of pdxB


High impact information on pdxB


Chemical compound and disease context of pdxB


Biological context of pdxB

  • Thus, pdxB must be the first gene in the complex pdxB-hisT operon [1].
  • The DNA sequence confirms results from previous minicell experiments showing that pdxB encodes a 41-kilodalton polypeptide [1].
  • We show that the minimum size of the operon is approximately 3,500 base pairs and that it contains at least four genes, which are arranged in the order usg-2 (pdxB), usg-1, hisT, and dsg-1 and encode polypeptides with apparent molecular masses of 42,000, 45,000, 31,000, and 17,000 daltons, respectively [11].
  • Complementation experiments confirmed that usg-2 is indeed pdxB, and inspection of the pyridoxine biosynthetic pathway suggests explanations for the unusual phenotypes of pdxB::Kmr mutants [12].

Associations of pdxB with chemical compounds


  1. Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12. Schoenlein, P.V., Roa, B.B., Winkler, M.E. J. Bacteriol. (1989) [Pubmed]
  2. Evolutionary relationship of NAD(+)-dependent D-lactate dehydrogenase: comparison of primary structure of 2-hydroxy acid dehydrogenases. Kochhar, S., Hunziker, P.E., Leong-Morgenthaler, P., Hottinger, H. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  3. Overexpression, crystallization and preliminary X-ray crystallographic analysis of erythronate-4-phosphate dehydrogenase from Pseudomonas aeruginosa. Ha, J.Y., Lee, J.H., Kim, K.H., Kim, d.o. .J., Lee, H.H., Kim, H.K., Yoon, H.J., Suh, S.W. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  4. Flavin adenine dinucleotide-dependent 4-phospho-D-erythronate dehydrogenase is responsible for the 4-phosphohydroxy-L-threonine pathway in vitamin B6 biosynthesis in Sinorhizobium meliloti. Tazoe, M., Ichikawa, K., Hoshino, T. J. Bacteriol. (2006) [Pubmed]
  5. Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12. Pease, A.J., Roa, B.R., Luo, W., Winkler, M.E. J. Bacteriol. (2002) [Pubmed]
  6. Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12. Yang, Y., Tsui, H.C., Man, T.K., Winkler, M.E. J. Bacteriol. (1998) [Pubmed]
  7. A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. Zhao, G., Winkler, M.E. J. Bacteriol. (1996) [Pubmed]
  8. Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. Lam, H.M., Winkler, M.E. J. Bacteriol. (1990) [Pubmed]
  9. Pyridoxine-requiring mutants of Escherichia coli: glycolaldehyde dehydrogenase is not coded for by the pdxB gene. Shimizu, S., Dempsey, W.B. J. Bacteriol. (1978) [Pubmed]
  10. A new family of 2-hydroxyacid dehydrogenases. Grant, G.A. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  11. Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette. Arps, P.J., Winkler, M.E. J. Bacteriol. (1987) [Pubmed]
  12. An unusual genetic link between vitamin B6 biosynthesis and tRNA pseudouridine modification in Escherichia coli K-12. Arps, P.J., Winkler, M.E. J. Bacteriol. (1987) [Pubmed]
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