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Gene Review

metC  -  cystathionine beta-lyase, PLP-dependent

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3000, JW2975
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Disease relevance of metC


High impact information on metC


Biological context of metC


Anatomical context of metC

  • The metC gene, which is known to code for a cystathione-beta-lyase, was cloned from the axilla isolate Corynebacterium striatum Ax20 and heterologously expressed in E. coli [9].

Associations of metC with chemical compounds


Other interactions of metC


Analytical, diagnostic and therapeutic context of metC


  1. Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region. Belfaiza, J., Parsot, C., Martel, A., de la Tour, C.B., Margarita, D., Cohen, G.N., Saint-Girons, I. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. DNA sequence of the metC gene and its flanking regions from Salmonella typhimurium LT2 and homology with the corresponding sequence of Escherichia coli. Park, Y.M., Stauffer, G.V. Mol. Gen. Genet. (1989) [Pubmed]
  3. Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. Clausen, T., Huber, R., Prade, L., Wahl, M.C., Messerschmidt, A. EMBO J. (1998) [Pubmed]
  4. The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl. van Der Ploeg, J.R., Iwanicka-Nowicka, R., Bykowski, T., Hryniewicz, M.M., Leisinger, T. J. Biol. Chem. (1999) [Pubmed]
  5. The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity. Steegborn, C., Messerschmidt, A., Laber, B., Streber, W., Huber, R., Clausen, T. J. Mol. Biol. (1999) [Pubmed]
  6. Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A. Clausen, T., Huber, R., Laber, B., Pohlenz, H.D., Messerschmidt, A. J. Mol. Biol. (1996) [Pubmed]
  7. A relationship between L-serine degradation and methionine biosynthesis in Escherichia coli K12. Brown, E.A., D'Ari, R., Newman, E.B. J. Gen. Microbiol. (1990) [Pubmed]
  8. Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia. Sajjan, U.S., Xie, H., Lefebre, M.D., Valvano, M.A., Forstner, J.F. Microbiology (Reading, Engl.) (2003) [Pubmed]
  9. Identification of odoriferous sulfanylalkanols in human axilla secretions and their formation through cleavage of cysteine precursors by a C-S lyase isolated from axilla bacteria. Natsch, A., Schmid, J., Flachsmann, F. Chem. Biodivers. (2004) [Pubmed]
  10. The metIC operon involved in methionine biosynthesis in Bacillus subtilis is controlled by transcription antitermination. Auger, S., Yuen, W.H., Danchin, A., Martin-Verstraete, I. Microbiology (Reading, Engl.) (2002) [Pubmed]
  11. Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli. Richaud, C., Mengin-Lecreulx, D., Pochet, S., Johnson, E.J., Cohen, G.N., Marlière, P. J. Biol. Chem. (1993) [Pubmed]
  12. Escherichia coli cystathionine gamma-synthase does not obey ping-pong kinetics. Novel continuous assays for the elimination and substitution reactions. Aitken, S.M., Kim, D.H., Kirsch, J.F. Biochemistry (2003) [Pubmed]
  13. Slow-binding inhibition of Escherichia coli cystathionine beta-lyase by L-aminoethoxyvinylglycine: a kinetic and X-ray study. Clausen, T., Huber, R., Messerschmidt, A., Pohlenz, H.D., Laber, B. Biochemistry (1997) [Pubmed]
  14. The metG gene of Aspergillus nidulans encoding cystathionine beta-lyase: cloning and analysis. Sieńko, M., Paszewski, A. Curr. Genet. (1999) [Pubmed]
  15. Cloning of an Arabidopsis thaliana cDNA encoding cystathionine beta-lyase by functional complementation in Escherichia coli. Ravanel, S., Ruffet, M.L., Douce, R. Plant Mol. Biol. (1995) [Pubmed]
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