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Chemical Compound Review

TETRAHYD-CPD     naphthalene-1,3,6,8-tetrol

Synonyms: SureCN704787, AG-E-34522, CHEBI:18365, CTK0H5975, AC1L98VM, ...
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Disease relevance of C04033


High impact information on C04033


Gene context of C04033


Analytical, diagnostic and therapeutic context of C04033

  • To begin a genetic analysis of the initial synthetic steps leading to 1,8-DHN melanin biosynthesis, a 772-bp PCR product was amplified from genomic DNA using primers based on conserved regions of fungal polyketide synthases (Pks) known to produce the first cyclized 1,8-DHN-melanin pathway intermediate, 1,3,6,8-tetrahydroxynaphthalene [8].


  1. Properties and substrate specificity of RppA, a chalcone synthase-related polyketide synthase in Streptomyces griseus. Funa, N., Ohnishi, Y., Ebizuka, Y., Horinouchi, S. J. Biol. Chem. (2002) [Pubmed]
  2. Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads. Gross, F., Luniak, N., Perlova, O., Gaitatzis, N., Jenke-Kodama, H., Gerth, K., Gottschalk, D., Dittmann, E., Müller, R. Arch. Microbiol. (2006) [Pubmed]
  3. Hydrolytic polyketide shortening by ayg1p, a novel enzyme involved in fungal melanin biosynthesis. Fujii, I., Yasuoka, Y., Tsai, H.F., Chang, Y.C., Kwon-Chung, K.J., Ebizuka, Y. J. Biol. Chem. (2004) [Pubmed]
  4. Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea. Cortés, J., Velasco, J., Foster, G., Blackaby, A.P., Rudd, B.A., Wilkinson, B. Mol. Microbiol. (2002) [Pubmed]
  5. Chip-based polyketide biosynthesis and functionalization. Ku, B., Cha, J., Srinivasan, A., Kwon, S.J., Jeong, J.C., Sherman, D.H., Dordick, J.S. Biotechnol. Prog. (2006) [Pubmed]
  6. Evidence for involvement of two naphthol reductases in the first reduction step of melanin biosynthesis pathway of Colletotrichum lagenarium. Tsuji, G., Sugahara, T., Fujii, I., Mori, Y., Ebizuka, Y., Shiraishi, T., Kubo, Y. Mycol. Res. (2003) [Pubmed]
  7. Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). Izumikawa, M., Shipley, P.R., Hopke, J.N., O'Hare, T., Xiang, L., Noel, J.P., Moore, B.S. J. Ind. Microbiol. Biotechnol. (2003) [Pubmed]
  8. Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis. Feng, B., Wang, X., Hauser, M., Kaufmann, S., Jentsch, S., Haase, G., Becker, J.M., Szaniszlo, P.J. Infect. Immun. (2001) [Pubmed]
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