Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L9A4A (2R,4R,5S,6R)-4- [(2S,4R,5R,6R)-2-carboxy-6...

Synonyms:

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Disease relevance of C06026

The genes for seven of nine enzymes needed for the biosynthesis of Kdo2-lipid A (Re endotoxin) in Escherichia coli have been reported [1].

High impact information on C06026

Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 [2].
The KDO2-lipid A (gmhB) mutant, which lacks the heptose disaccharide in the inner core of LOS, avidly attached to epithelial cells but was otherwise avirulent [3].
In the present work we report the discovery of a Kdo hydrolase in membranes of H. pylori capable of removing the outer Kdo sugar from Kdo2-lipid A [4].
The example of the types of structural information that can be obtained from MALDI-TOF tandem mass spectrometry is exemplified by the analysis of Kdo2-lipid A, a complex lipopolysaccharide known to activate toll-like 4 receptors on mammalian cells [5].
Analysis of Kdo2-lipid A obtained from an Escherichia coli WBB06 was found to generate an abundant [M-H]- ion at m/z 2236.4 and a more abundant carbon-13 isotope at m/z 2237 [5].

References

Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. Garrett, T.A., Kadrmas, J.L., Raetz, C.R. J. Biol. Chem. (1997) [Pubmed]
Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. Raetz, C.R., Garrett, T.A., Reynolds, C.M., Shaw, W.A., Moore, J.D., Smith, D.C., Ribeiro, A.A., Murphy, R.C., Ulevitch, R.J., Fearns, C., Reichart, D., Glass, C.K., Benner, C., Subramaniam, S., Harkewicz, R., Bowers-Gentry, R.C., Buczynski, M.W., Cooper, J.A., Deems, R.A., Dennis, E.A. J. Lipid Res. (2006) [Pubmed]
Lipooligosaccharide structure contributes to multiple steps in the virulence of Neisseria meningitidis. Plant, L., Sundqvist, J., Zughaier, S., Lövkvist, L., Stephens, D.S., Jonsson, A.B. Infect. Immun. (2006) [Pubmed]
A novel 3-deoxy-D-manno-octulosonic acid (Kdo) hydrolase that removes the outer Kdo sugar of Helicobacter pylori lipopolysaccharide. Stead, C., Tran, A., Ferguson, D., McGrath, S., Cotter, R., Trent, S. J. Bacteriol. (2005) [Pubmed]
Mass spectrometry advances in lipidomica: collision-induced decomposition of Kdo2-lipid A. Murphy, R.C., Raetz, C.R., Reynolds, C.M., Barkley, R.M. Prostaglandins Other Lipid Mediat. (2005) [Pubmed]

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