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Chemical Compound Review

QWCNQXNAFCBLLV-SJORKVTESA-N     (3R,8S)-heptadeca-1,9-dien- 4,6-diyne-3,8-diol

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High impact information on C08449

  • Falcarindiol modulated the nuclear translocation of signal transducer and activator of transcription 1 (Stat1) in a time-dependent manner [1].
  • The inhibitory effect of falcarindiol on iNOS induction was attributable to decrease in the protein content and the mRNA level of iNOS [1].
  • Falcarindiol abrogated the LPS/IFN-gamma-mediated induction of iNOS by about 80% [1].
  • Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes [1].
  • Treatment with 50 microM of falcarindiol for 60 min diminished the LPS/IFN-gamma-mediated activation of IkappaB kinase-alpha (IKK-alpha) and IKK-beta by 28.2 and 29.7%, respectively [1].

Biological context of C08449


Anatomical context of C08449

  • Falcarindiol dose-dependently reduced inducible NO synthase (iNOS)-mediated NO production without cytotoxic effects on LPS-activated BV-2 and microglia [3].

Associations of C08449 with other chemical compounds


Gene context of C08449

  • Of the isolated pure compounds, imperatorin and falcarindiol inactivated the GABA-T activities in both time- and concentration-dependent manners [5].


  1. Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes. Shiao, Y.J., Lin, Y.L., Sun, Y.H., Chi, C.W., Chen, C.F., Wang, C.N. Br. J. Pharmacol. (2005) [Pubmed]
  2. Spatial tissue distribution of polyacetylenes in carrot root. Baranska, M., Schulz, H. The Analyst. (2005) [Pubmed]
  3. Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures. Kim, J.M., Lee, P., Son, D., Kim, H., Kim, S.Y. Neuroreport (2003) [Pubmed]
  4. Antiproliferative constituents in Umbelliferae plants II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. Nakano, Y., Matsunaga, H., Saita, T., Mori, M., Katano, M., Okabe, H. Biol. Pharm. Bull. (1998) [Pubmed]
  5. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica. Choi, S.Y., Ahn, E.M., Song, M.C., Kim, D.W., Kang, J.H., Kwon, O.S., Kang, T.C., Baek, N.I. Phytotherapy research : PTR. (2005) [Pubmed]
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