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Gene Review

Stat1  -  signal transducer and activator of...

Rattus norvegicus

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Disease relevance of Stat1

  • These results, favor the notion that ejaculation-induced prolactin secretion activates its prostate receptors resulting in Stat-1 and Stat-3 nuclear translocation, event likely to be associated to the so-called benign prostate hyperplasia [1].
  • Thus, we examined the role of the Ras-MAPK pathway in Stat1 activation and subsequent iNOS induction in C6 glioma cells [2].
  • Ischemia caused a strong induction of Stat1 in the ipsilateral cortex after 4, 7 and 15 days, but not at 6 or 24 h [3].
  • These results show that Stat1 is normally expressed in the postnatal and adult rat brain and is induced under brain infarction [3].
  • In this study, activation of the Jak/Stat signaling pathway was followed upon growth hormone (GH) stimulation, using the rat osteosarcoma cell-line UMR-106.01 that expresses high affinity GH receptors [4].

High impact information on Stat1

  • Because Stat factors are known to be inactivated by protein tyrosine phosphatases (PTPase), we showed that a PTPase is able to eliminate the DNA binding of hepatic Stat3.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
  • Functional prolactin receptor signaling was further demonstrated in the activation of JAK2 and phosphorylation activation of the transcription factors Stat1, -3, and -5a [6].
  • However, we discovered a profound difference in the expression of SOCS-1, an inhibitor of the Jak/Stat pathway [7].
  • The PRL response element (PRLRE) binds PRL-activated (tyrosine-phosphorylated) signal transducers and activators of transcription (Stat 5b and Stat 5a) [8].
  • Cotransfection with a vector expressing a dominant negative, truncated form of Stat 5b abolished PRL-induced activation of a2M transgenes [8].

Chemical compound and disease context of Stat1


Biological context of Stat1


Anatomical context of Stat1


Associations of Stat1 with chemical compounds


Physical interactions of Stat1

  • The 92 kD Stat factor binding at the IL-6 RE probably also functions as a transcription factor in the cytokine-induced activation of the alpha 2M gene [16].

Regulatory relationships of Stat1

  • We also investigated EGF-induced activation of Stat (signal transducers and activators of transcription) proteins as well as the possible interactions of this signaling pathway with the p38 and p42/44 MAP kinases cascades [17].

Other interactions of Stat1

  • Prolactin receptors as members of the cytokine-hematopoietin receptor superfamily, are linked to Stat activation [1].
  • Stat1 was phosphorylated on tyrosine (Tyr)-701 after exposure to H(2)O(2), INF-gamma or IL-6 but not IL-10 [10].
  • Falcarindiol also abrogated the tyrosine phoshorylation of JAK2 by 82.3% at 10 min.The present study demonstrates that falcarindiol attenuated the activation of IKK and JAK contributing to the blockade of activation of NF-kappaB and Stat1, thereby leading to the suppression of iNOS expression [14].
  • Recent studies have reported that MAPK is responsible for serine phosphorylation of Stat1 which is required for Stat1's DNA binding and maximal transcriptional activity [2].
  • Using retroviral luciferase reporters, we found that NE also activated both signal transducers and activators of transcription (Stat) and gamma-interferon-activated sequence-mediated transcriptional responses, with maximal effects similar to those caused by interleukin-6 (IL-6) [15].

Analytical, diagnostic and therapeutic context of Stat1


  1. Signal transducers and activators of transcription 1 and 3 in prostate: effect of sexual activity. Soto-Cid, A., Hernández-Kelly, L.C., Hernández, M.E., Manzo, J., González-Mejia, M.E., Zepeda, R.C., Ortega, A. Life Sci. (2006) [Pubmed]
  2. Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-gamma-induced MAPK activation that is mediated by p21ras. Nishiya, T., Uehara, T., Edamatsu, H., Kaziro, Y., Itoh, H., Nomura, Y. FEBS Lett. (1997) [Pubmed]
  3. Stat1 in developing and adult rat brain. Induction after transient focal ischemia. Planas, A.M., Justicia, C., Ferrer, I. Neuroreport (1997) [Pubmed]
  4. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Gerland, K., Bataillé-Simoneau, N., Baslé, M., Fourcin, M., Gascan, H., Mercier, L. Mol. Cell. Endocrinol. (2000) [Pubmed]
  5. Rapid activation of the Stat3 transcription complex in liver regeneration. Cressman, D.E., Diamond, R.H., Taub, R. Hepatology (1995) [Pubmed]
  6. Prolactin-induced cell proliferation in PC12 cells depends on JNK but not ERK activation. Cheng, Y., Zhizhin, I., Perlman, R.L., Mangoura, D. J. Biol. Chem. (2000) [Pubmed]
  7. Involvement of SOCS-1, the suppressor of cytokine signaling, in the prevention of prolactin-responsive gene expression in decidual cells. Barkai, U., Prigent-Tessier, A., Tessier, C., Gibori, G.B., Gibori, G. Mol. Endocrinol. (2000) [Pubmed]
  8. Stat 5b and the orphan nuclear receptors regulate expression of the alpha2-macroglobulin (alpha2M) gene in rat ovarian granulosa cells. Dajee, M., Fey, G.H., Richards, J.S. Mol. Endocrinol. (1998) [Pubmed]
  9. Role of oxidative stress in the increased activation of signal transducers and activators of transcription-3 in the fatty livers of obese Zucker rats. Dikdan, G.S., Saba, S.C., Dela Torre, A.N., Roth, J., Wang, S., Koneru, B. Surgery (2004) [Pubmed]
  10. AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway. Gorina, R., Petegnief, V., Chamorro, A., Planas, A.M. J. Neurochem. (2005) [Pubmed]
  11. Down-regulation of interferon-gamma signaling by gene transfer of Stat1 mutant in mesangial cells. Sakatsume, M., Narita, I., Yamazaki, H., Saito, A., Nakagawa, Y., Kuriyama, H., Kuwano, R., Gejyo, F., Arakawa, M. Kidney Int. (2000) [Pubmed]
  12. The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes. McWhinney, C.D., Hunt, R.A., Conrad, K.M., Dostal, D.E., Baker, K.M. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  13. EGF-induced activation of Stat1, Stat3, and Stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes. Guren, T.K., Abrahamsen, H., Thoresen, G.H., Babaie, E., Berg, T., Christoffersen, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  14. Falcarindiol impairs the expression of inducible nitric oxide synthase by abrogating the activation of IKK and JAK in rat primary astrocytes. Shiao, Y.J., Lin, Y.L., Sun, Y.H., Chi, C.W., Chen, C.F., Wang, C.N. Br. J. Pharmacol. (2005) [Pubmed]
  15. Activation of signal transducers and activators of transcription by alpha(1A)-adrenergic receptor stimulation in PC12 cells. Zhong, H., Murphy, T.J., Minneman, K.P. Mol. Pharmacol. (2000) [Pubmed]
  16. Isolation of two interleukin-6 response element binding proteins from acute phase rat livers. Ripperger, J., Fritz, S., Richter, K., Dreier, B., Schneider, K., Löchner, K., Marschalek, R., Hocke, G., Lottspeich, F., Fey, G.H. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  17. Epidermal growth factor induces hypertrophic responses and Stat5 activation in rat ventricular cardiomyocytes. Rebsamen, M.C., Arrighi, J.F., Juge-Aubry, C.E., Vallotton, M.B., Lang, U. J. Mol. Cell. Cardiol. (2000) [Pubmed]
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