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Chemical Compound Review

rac-Falcarinol     (9Z)-heptadeca-1,9-dien-4,6- diyn-3-ol

Synonyms: MEGxp0_001453, LMFA05000019, NP-007699, AC1NR1WQ, 4117-12-8, ...
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Psychiatry related information on Panaxynol

  • It is suggested that the promotion of neuritogenesis in cultured paraneurons by the addition of panaxynol is related its ability to improve memory deficits in animals [1].

High impact information on Panaxynol


Biological context of Panaxynol


Anatomical context of Panaxynol

  • Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms [9].
  • Inhibition of 15-hydroxyprostaglandin dehydrogenase activity in rabbit gastric antral mucosa by panaxynol isolated from oriental medicines [11].
  • Panaxynol inhibited the growth of various kinds of cultured tumor cell lines in a dose-dependent manner [8].
  • These results suggest that panaxynol has the potential to inhibit PGDH activity in gastric mucosa, possibly as a result of pharmacological activity [11].

Associations of Panaxynol with other chemical compounds


Gene context of Panaxynol

  • Results indicated that the levels of cyclin E mRNA in various tumor cells were decreased by panaxynol [7].
  • Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster [12].
  • The neurite outgrowth in PC12D cells induced by panaxynol could be inhibited by the protein kinase A inhibitor RpcAMPS and by MAP kinase kinase 1/2 inhibitor U0126 [9].
  • Cell-cycle analysis indicated that panaxynol arrested the cell cycle progression of tumor cells from the G1 transition to the S phase [7].

Analytical, diagnostic and therapeutic context of Panaxynol


  1. Effect of polyacetylenes on the neurite outgrowth of neuronal culture cells and scopolamine-induced memory impairment in mice. Yamazaki, M., Hirakura, K., Miyaichi, Y., Imakura, K., Kita, M., Chiba, K., Mohri, T. Biol. Pharm. Bull. (2001) [Pubmed]
  2. Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases. Alanko, J., Kurahashi, Y., Yoshimoto, T., Yamamoto, S., Baba, K. Biochem. Pharmacol. (1994) [Pubmed]
  3. Up-regulation of M1 muscarinic receptors expressed in CHOm1 cells by panaxynol via cAMP pathway. Hao, W., Xing-Jun, W., Yong-Yao, C., Liang, Z., Yang, L., Hong-Zhuan, C. Neurosci. Lett. (2005) [Pubmed]
  4. Polyacetylenes in hairy roots of a panax hybrid. Washida, D., Shimomura, K., Kitanaka, S. Planta Med. (2003) [Pubmed]
  5. Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium. Wang, C.N., Shiao, Y.J., Kuo, Y.H., Chen, C.C., Lin, Y.L. Planta Med. (2000) [Pubmed]
  6. Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA : cholesterol acyltransferase. Kwon, B.M., Ro, S.H., Kim, M.K., Nam, J.Y., Jung, H.J., Lee, I.R., Kim, Y.K., Bok, S.H. Planta Med. (1997) [Pubmed]
  7. A tumor cell growth inhibitor from Saposhnikovae divaricata. Kuo, Y.C., Lin, Y.L., Huang, C.P., Shu, J.W., Tsai, W.J. Cancer Invest. (2002) [Pubmed]
  8. The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol. Saita, T., Katano, M., Matsunaga, H., Yamamoto, H., Fujito, H., Mori, M. Chem. Pharm. Bull. (1993) [Pubmed]
  9. Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. Wang, Z.J., Nie, B.M., Chen, H.Z., Lu, Y. Chem. Biol. Interact. (2006) [Pubmed]
  10. Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons. Nie, B.M., Yang, L.M., Fu, S.L., Jiang, X.Y., Lu, P.H., Lu, Y. Chem. Biol. Interact. (2006) [Pubmed]
  11. Inhibition of 15-hydroxyprostaglandin dehydrogenase activity in rabbit gastric antral mucosa by panaxynol isolated from oriental medicines. Fujimoto, Y., Sakuma, S., Komatsu, S., Sato, D., Nishida, H., Xiao, Y.Q., Baba, K., Fujita, T. J. Pharm. Pharmacol. (1998) [Pubmed]
  12. Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II. Takai, S., Jin, D., Kirimura, K., Ikeda, J., Sakaguchi, M., Baba, K., Fujita, T., Miyazaki, M. Jpn. J. Pharmacol. (1999) [Pubmed]
  13. Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Teng, C.M., Kuo, S.C., Ko, F.N., Lee, J.C., Lee, L.G., Chen, S.C., Huang, T.F. Biochim. Biophys. Acta (1989) [Pubmed]
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