Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL505251 (2S,3R,4S,5S,6R)-2-[2-(3,4...

Synonyms: CHEBI:28064, LS-194245, LS-194569, AC1L9BG1, C08620, ...

Youdim, K.A. et al., Kapasakalidis, P.G. et al., Rechner, A.R. et al., Reen, R.K. et al., Kano, E. et al.

Reen, Nines, Stoner,

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High impact information on KERACYANIN

We report that the citrus flavonoids, hesperetin, naringenin and their relevant in vivo metabolites, as well as the dietary anthocyanins and in vivo forms, cyanidin-3-rutinoside and pelargonidin-3-glucoside, are taken up by two brain endothelial cell lines from mouse (b.END5) and rat (RBE4) [1].
Similarly, in liver microsomes, the inhibition was maximal by cyanidin-3-rutinoside (47%) followed by EA (33%) and cyanidin-3-glucoside (32%) [2].
The four major native anthocyanidin glycosides of blackcurrant juice, delphinidin-3-glucoside, delphinidin-3-rutinoside, cyanidin-3-glucoside and cyanidin-3-rutinoside, were detected and identified in low amounts by HPLC and LC-MS in plasma and urine post-ingestion [3].
Dose-modifying effect of a cyanidine chloride derivative, keracyanin, for uv irradiation of murine L fibroblasts cultured in vitro [4].
HPLC analysis revealed that delphinidin-3-O-glucoside, delphinidin-3-O-rutinoside, cyanidin-3-O-glucoside, and cyanidin-3-O-rutinoside were the major anthocyanins and constituted the main phenol class ( approximately 90%) in both types of black currant tissues tested [5].

References

Interaction between flavonoids and the blood-brain barrier: in vitro studies. Youdim, K.A., Dobbie, M.S., Kuhnle, G., Proteggente, A.R., Abbott, N.J., Rice-Evans, C. J. Neurochem. (2003) [Pubmed]
Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats. Reen, R.K., Nines, R., Stoner, G.D. Nutrition and cancer. (2006) [Pubmed]
The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Rechner, A.R., Kuhnle, G., Hu, H., Roedig-Penman, A., van den Braak, M.H., Moore, K.P., Rice-Evans, C.A. Free Radic. Res. (2002) [Pubmed]
Dose-modifying effect of a cyanidine chloride derivative, keracyanin, for uv irradiation of murine L fibroblasts cultured in vitro. Kano, E., Miyakoshi, J., Ikebuchi, M., Yamagata, K., Sugahara, T. Radiat. Res. (1979) [Pubmed]
Extraction of polyphenols from processed black currant (Ribes nigrum L.) residues. Kapasakalidis, P.G., Rastall, R.A., Gordon, M.H. J. Agric. Food Chem. (2006) [Pubmed]

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