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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ribes

  • To investigate the absorption and metabolism of anthocyanins (ACNs) with different aglycones and sugar moieties, weanling pigs (11.4 +/- 3.8 kg) were fed, in a single meal, a freeze-dried powder of chokeberry, black currant, or elderberry at a single dose of 229, 140, or 228 mumol total ACN/kg body weight (BW), respectively [1].

High impact information on Ribes

  • OBJECTIVE: Our objective was to investigate the effect of intake of flavonoid-containing black currant and apple juice on urinary excretion of quercetin and on markers of oxidative status [2].
  • Short-term, high intake of black currant and apple juices had a prooxidant effect on plasma proteins and increased glutathione peroxidase activity, whereas lipid oxidation in plasma seemed to decrease [2].
  • Over 80% of the ACN compounds containing rutinose or sambubiose, which were excreted in the urine from black currant, elderberry, or Marion blackberry, were excreted as the intact molecule [1].
  • For each of the taste stimuli, glucose, NaCl, HCl, QHCl, water, and black currant juice, there was one group of neurons that responded much more to that tastant than to the other tastants [3].
  • Delphinidin-3-rutinoside (D3R) is the major anthocyanin component in blackcurrant (Ribes nigrum L.) fruits [4].

Chemical compound and disease context of Ribes

  • Embelin, extracted from Embelia ribes Burm. berries, altered the testicular histology and glycogen, gametogenic counts and accessory sex gland fructose at the dose levels 0.3, 0.4 and 0.5 mg/kg body weight administered subcutaneously for 35 days [5].

Biological context of Ribes

  • One of the most effective preparations, that from the leaves of Ribes nigrum, has IC50 values with respect to cAK, PKC, CDPK and MLCK of 0.009, 0.6, 2.0 and 16 microM, respectively [6].

Anatomical context of Ribes


Associations of Ribes with chemical compounds


Gene context of Ribes

  • Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1 [16].
  • Black currant juice showed highest antioxidant activity in all tests compared to tea, apple juice and tomato juice [17].
  • Increased levels of GLA and DHLA were present in the plasma phospholipid fraction of animals fed the black currant seed oil diet, while soy-fed animals had only trace amounts of GLA [18].
  • Hepatic quinone reductase activity, on the other hand, was significantly increased by grapefruit juice, apple juice, and black currant juice [19].
  • Four anthocyanin components of black currant, delphinidin 3-O-beta-rutinoside (D3R), cyanidin 3-O-beta-rutinoside (C3R), delphinidin 3-O-beta-glucoside (D3G), and cyanidin 3-O-beta-glucoside (C3G), were successfully isolated as crystalline forms on a preparative scale [20].

Analytical, diagnostic and therapeutic context of Ribes


  1. Aglycones and sugar moieties alter anthocyanin absorption and metabolism after berry consumption in weanling pigs. Wu, X., Pittman, H.E., McKay, S., Prior, R.L. J. Nutr. (2005) [Pubmed]
  2. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Young, J.F., Nielsen, S.E., Haraldsdóttir, J., Daneshvar, B., Lauridsen, S.T., Knuthsen, P., Crozier, A., Sandström, B., Dragsted, L.O. Am. J. Clin. Nutr. (1999) [Pubmed]
  3. Gustatory responses of single neurons in the insula of the macaque monkey. Yaxley, S., Rolls, E.T., Sienkiewicz, Z.J. J. Neurophysiol. (1990) [Pubmed]
  4. Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway. Matsumoto, H., Kamm, K.E., Stull, J.T., Azuma, H. Exp. Eye Res. (2005) [Pubmed]
  5. Antifertility effects of embelin in male rats. Agrawal, S., Chauhan, S., Mathur, R. Andrologia (1986) [Pubmed]
  6. Differential inhibition of eukaryote protein kinases by condensed tannins. Wang, B.H., Foo, L.Y., Polya, G.M. Phytochemistry (1996) [Pubmed]
  7. Effects of prodelphinidins isolated from Ribes nigrum on chondrocyte metabolism and COX activity. Garbacki, N., Angenot, L., Bassleer, C., Damas, J., Tits, M. Naunyn Schmiedebergs Arch. Pharmacol. (2002) [Pubmed]
  8. Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats. Farombi, E.O., Hansen, M., Ravn-Haren, G., Møller, P., Dragsted, L.O. Food Chem. Toxicol. (2004) [Pubmed]
  9. Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. Matsumoto, H., Nakamura, Y., Tachibanaki, S., Kawamura, S., Hirayama, M. J. Agric. Food Chem. (2003) [Pubmed]
  10. Histochemical localization of alkaline phosphatase in the uterus of rats: response to a few indigenous plant extracts. Mathur, R. Acta Eur. Fertil. (1986) [Pubmed]
  11. Characterization of gamma-linolenic acid in Ribes seed. Traitler, H., Winter, H., Richli, U., Ingenbleek, Y. Lipids (1984) [Pubmed]
  12. Black currant seed oil feeding and fatty acids in liver lipid classes of guinea pigs. Crozier, G.L., Fleith, M., Traitler, H., Finot, P.A. Lipids (1989) [Pubmed]
  13. Separation of gamma- and alpha-linolenic acid containing triacylglycerols by capillary supercritical fluid chromatography. Manninen, P., Laakso, P., Kallio, H. Lipids (1995) [Pubmed]
  14. Identification of (all-cis)-6,9,12,15-octadecatetraenoic acid in Ribes nigrum and fish oils: chemical and physical characterization. Moine, G., Forzy, L., Oesterhelt, G. Chem. Phys. Lipids (1992) [Pubmed]
  15. Inhibitory effect of stearidonic acid (18:4 n-3) on platelet aggregation and arachidonate oxygenation. Kockmann, V., Spielmann, D., Traitler, H., Lagarde, M. Lipids (1989) [Pubmed]
  16. Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1. Garbacki, N., Kinet, M., Nusgens, B., Desmecht, D., Damas, J. Journal of inflammation (London, England) (2005) [Pubmed]
  17. Assessment of antioxidant activity by using different in vitro methods. Schlesier, K., Harwat, M., Böhm, V., Bitsch, R. Free Radic. Res. (2002) [Pubmed]
  18. The response to endotoxin in guinea pigs after intravenous black currant seed oil. Hirschberg, Y., Shackelford, A., Mascioli, E.A., Babayan, V.K., Bistrian, B.R., Blackburn, G.L. Lipids (1990) [Pubmed]
  19. Effects of commonly consumed fruit juices and carbohydrates on redox status and anticancer biomarkers in female rats. Breinholt, V.M., Nielsen, S.E., Knuthsen, P., Lauridsen, S.T., Daneshvar, B., Sorensen, A. Nutrition and cancer. (2003) [Pubmed]
  20. Preparative-scale isolation of four anthocyanin components of black currant (Ribes nigrum L.) fruits. Matsumoto, H., Hanamura, S., Kawakami, T., Sato, Y., Hirayama, M. J. Agric. Food Chem. (2001) [Pubmed]
  21. Current status of fertility control methods in India. Sharma, R.S., Rajalakshmi, M., Sharma, R.S., Jeyaraj, D.A. J. Biosci. (2001) [Pubmed]
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