Disease relevance of C08604

• Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the Apc(Min) mouse model of intestinal carcinogenesis-Relationship with tissue anthocyanin levels [1].
• Here, we have investigated the therapeutic efficacy of anthocyanins contained in blackberry extract (cyanidin-3-O-glucoside represents about 80% of the total anthocyanin contents) in an experimental model of lung inflammation induced by carrageenan in rats [2].
• Female Sprague-Dawley rats (body weight 100 g) orally ingested a single dose of anthocyanin mixture (total 100 mg) composed of cyanidin-3-glucoside (50mg), cyanidin-3-sambubioside (48 mg), and cyanidin-3,5-diglucoside (2 mg) [3].

High impact information on C08604

• Previously we reported that cyanidin-3-glucoside (Cy3G) induced endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) production in bovine vascular endothelial cells [4].
• Similarly, in liver microsomes, the inhibition was maximal by cyanidin-3-rutinoside (47%) followed by EA (33%) and cyanidin-3-glucoside (32%) [5].
• Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol [6].
• HPLC analysis revealed that delphinidin-3-O-glucoside, delphinidin-3-O-rutinoside, cyanidin-3-O-glucoside, and cyanidin-3-O-rutinoside were the major anthocyanins and constituted the main phenol class ( approximately 90%) in both types of black currant tissues tested [7].
• Effect of cyanidin-3-O-glucoside on UVB-induced response in human keratinocytes [8].

Chemical compound and disease context of C08604

• A significant attenuation of hind paw inflammation characterized by fluid accumulation, uric acid production, and rheumatoid factors induced by carrageenan was observed following the intake of both ME (50 mg/kg of body weight) and C3G (10 mg/kg of body weight) [9].

Biological context of C08604

• Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase [4].
• Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans [10].
• Among the colors tested, betanin, cyanidin-3-O-glucoside, lycopene, and beta-carotene inhibited lipid peroxidation [11].
• The present study was designed to determine the potential bioavailability in humans of the most important anthocyanins of blackcurrants: delphinidine-3-glucoside, delphinidine-3-rutinoside, cyanidine-3-glucoside, and cyanidine-3-rutinoside [12].
• Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment [13].

Anatomical context of C08604

• In the present study, we examined the effect of d-glucose (main substrate of SGLT1), phloridzin (inhibitor of SGLT1), and quercetin-3-glucose (Q3G, a flavonol) on the absorption of cyanidin-3-glucoside (C3G; approximately 5 micromol/L) by mouse jejunum mounted in Ussing chambers [14].

Associations of C08604 with other chemical compounds

• Pure betanin, bixin, lycopene, chlorophyll, beta-carotene, and cyanidin-3-O-glucoside were isolated from Beta vulgaris, Bixa orellana,Lycopersicum esculentum, Spinacia oleracea, Daucus carrota, and Prunus cerasus, respectively [11].
• The flavonol quercetin-3-glucoside inhibits cyanidin-3-glucoside absorption in vitro [14].
• An enzyme catalyzing the transfer of the glucosyl moiety of UDP-glucose to the 3-hydroxyl group of cyanidin has been demonstrated in petal extracts of Silene dioica mutants with cyanidin-3-O-glucoside in the petals [15].

Gene context of C08604

• The aim of this study was to evaluate the efficacy of cyanidin-3-O-glucoside (C3G) on modulation of cellular responses following exposure to UVB doses in human keratinocytes (HaCaT) [8].

Analytical, diagnostic and therapeutic context of C08604

• HPLC results were compared with spectrophotometric measurements, using a calibration curve obtained for cyanidin-3-glucoside solutions [16].

References