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Chemical Compound Review:

AC1L9DYZ [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms:

Scherf, U. et al., Martins, B.M. et al., Cinkaya, I. et al., Scherf, U. et al., Müh, U. et al., et al.

Martins, Dobbek, Cinkaya, Buckel, Messerschmidt,

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Disease relevance of C11062

The structure provides insight into the function of these ubiquitous prosthetic groups in the chemically nonfacile, radical-mediated dehydration of 4-hydroxybutyryl-CoA [1].
Interestingly, the enzyme is almost identical to the previously isolated 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum [2].

High impact information on C11062

Crystal structure of 4-hydroxybutyryl-CoA dehydratase: radical catalysis involving a [4Fe-4S] cluster and flavin [1].
Purification and properties of an iron-sulfur and FAD-containing 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase from Clostridium aminobutyricum [3].

Chemical compound and disease context of C11062

4-Hydroxybutyryl-CoA dehydratase catalyzes the reversible dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA, which involves cleavage of an unactivated beta-C-H bond [4].
Electron-nuclear double resonance spectroscopy investigation of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: comparison with other flavin radical enzymes [5].
Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA [6].
Anaerobically prepared cell extracts of Clostridium kluyveri grown on succinate plus ethanol contained high amounts of 4-hydroxybutyryl-CoA dehydratase, which catalyzes the reversible dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA [2].

References

Crystal structure of 4-hydroxybutyryl-CoA dehydratase: radical catalysis involving a [4Fe-4S] cluster and flavin. Martins, B.M., Dobbek, H., Cinkaya, I., Buckel, W., Messerschmidt, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Succinate-ethanol fermentation in Clostridium kluyveri: purification and characterisation of 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase. Scherf, U., Söhling, B., Gottschalk, G., Linder, D., Buckel, W. Arch. Microbiol. (1994) [Pubmed]
Purification and properties of an iron-sulfur and FAD-containing 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase from Clostridium aminobutyricum. Scherf, U., Buckel, W. Eur. J. Biochem. (1993) [Pubmed]
4-Hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: characterization of FAD and iron-sulfur clusters involved in an overall non-redox reaction. Müh, U., Cinkaya, I., Albracht, S.P., Buckel, W. Biochemistry (1996) [Pubmed]
Electron-nuclear double resonance spectroscopy investigation of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: comparison with other flavin radical enzymes. Cinkaya, I., Buckel, W., Medina, M., Gomez-Moreno, C., Cammack, R. Biol. Chem. (1997) [Pubmed]
Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA. Gerhardt, A., Cinkaya, I., Linder, D., Huisman, G., Buckel, W. Arch. Microbiol. (2000) [Pubmed]

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