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Chemical Compound Review:

S-Decyl GSH (2S)-2-amino-4-[[(1S)-1...

Synonyms: AG-D-12684, CHEMBL2074814, CTK4A1495, AC1L9E1W, C11303, ...

Cool, R.H. et al., Ravasi, S. et al., Mao, Q. et al., Chiono, M. et al., Capra, V. et al.

Cool, Veenstra, van Klompenburg, Heyne, Müller, de Vries, van Veen, Konings,

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High impact information on S-Decyl glutathione

LTC(4) uptake was also markedly reduced by the competitive inhibitor, S-decyl-glutathione, as well as by the MRP1 substrates 17 beta-estradiol 17-beta-(d-glucuronide), oxidized glutathione, and vincristine in the presence of reduced glutathione [1].
The use of S-decyl-glutathione allowed us to characterize a previously unidentified high affinity binding site for LTC4 [2].
We have previously reported, by means of equilibrium binding studies, the existence of two distinct binding sites with receptor characteristics for LTC(4) and LTD(4) in human lung parenchyma (HLP) membranes using S-decyl-glutathione (S-decyl-GSH) to inhibit LTC(4) binding to a number of non-receptor sites [3].
Glutathione, S-decyl-glutathione and hematin had Ki values of 35,000, 280 and 29,000 nM, respectively, suggesting the binding site is not the enzyme LTC4-synthase [4].
However,the stimulation of the ATPase activity was found to coincide with the formation of micelles by S-decyl-glutathione [5].

Gene context of S-Decyl glutathione

Remarkably, S-decyl-glutathione, a conjugate specifically transported by MRP1 and MRP2, was able to stimulate the ATPase activities of the isolated NBDs more than 2-fold in a concentration-dependent manner [5].

References

Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. Mao, Q., Deeley, R.G., Cole, S.P. J. Biol. Chem. (2000) [Pubmed]
Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. Capra, V., Nicosia, S., Ragnini, D., Mezzetti, M., Keppler, D., Rovati, G.E. Mol. Pharmacol. (1998) [Pubmed]
Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. Ravasi, S., Capra, V., Panigalli, T., Rovati, G.E., Nicosia, S. Biochem. Pharmacol. (2002) [Pubmed]
Characterization and localization of leukotriene C4 receptors in bullfrog lung. Chiono, M., Andazola, J.J., Torres, O.A., Herman, C.A. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
S-decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1). Cool, R.H., Veenstra, M.K., van Klompenburg, W., Heyne, R.I., Müller, M., de Vries, E.G., van Veen, H.W., Konings, W.N. Eur. J. Biochem. (2002) [Pubmed]

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