The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ABCC1  -  ATP-binding cassette, sub-family C...

Homo sapiens

Synonyms: ABC29, ABCC, ATP-binding cassette sub-family C member 1, GS-X, LTC4 transporter, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ABCC1


Psychiatry related information on ABCC1

  • Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products [6].
  • We will show you how to pinpoint MRP II problems and attack them through self-assessment audits [7].
  • Real life experiences were used to put together this list of steps to be followed during the planning and implementation of a formal MRP II planning and control system [8].

High impact information on ABCC1

  • Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism [9].
  • Thus, MRP-1 regulates DC migration to lymph nodes, apparently by transporting LTC(4), which in turn promotes chemotaxis to CCL19 and mobilization of DCs from the epidermis [10].
  • Here, we show that DC migration from skin to lymph nodes utilizes the leukotriene C(4) (LTC(4)) transporter multidrug resistance-associated protein 1 (MRP1) [10].
  • DC mobilization from the epidermis and trafficking into lymphatic vessels was greatly reduced in MRP1(-/-) mice, but migration was restored by exogenous cysteinyl leukotrienes LTC(4) or LTD(4) [10].
  • Overexpression of the gene for the multidrug-resistance-associated protein (MRP) has been linked with resistance to chemotherapeutic agents (multidrug resistance) in vitro [4].

Chemical compound and disease context of ABCC1


Biological context of ABCC1


Anatomical context of ABCC1


Associations of ABCC1 with chemical compounds


Physical interactions of ABCC1


Regulatory relationships of ABCC1


Other interactions of ABCC1


Analytical, diagnostic and therapeutic context of ABCC1

  • High levels of MRP expression were strongly associated with reductions in both survival and event-free survival (P < 0.001) in the overall study population and in subgroups of patients without N-myc amplification and patients with localized disease [4].
  • Coupled reverse transcription-polymerase chain reaction (RT-PCR) was used to evaluate mdr1, MRP, Topo II alpha, and Topo II beta gene expression [41].
  • METHODS: Using specific antibodies, MRP1 protein levels and cellular localization were examined by Western blotting and fluorescence confocal microscopy, respectively [5].
  • Noninvasive single-photon-emission computed tomography with 99mTc-sestamibi, a membrane-permeant radiopharmaceutical whose transport is mediated by both Pgp and MRP, shows a large blood-to-CSF concentration gradient across intact CP epithelium in humans in vivo [42].
  • In the present study, the first structural details of MRP1 purified from drug-resistant lung cancer cells have been obtained by electron microscopy of negatively stained single particles and two-dimensional crystals formed after reconstitution of purified protein with lipids [43].


  1. Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins. Diah, S.K., Smitherman, P.K., Aldridge, J., Volk, E.L., Schneider, E., Townsend, A.J., Morrow, C.S. Cancer Res. (2001) [Pubmed]
  2. Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Hooijberg, J.H., Jansen, G., Assaraf, Y.G., Kathmann, I., Pieters, R., Laan, A.C., Veerman, A.J., Kaspers, G.J., Peters, G.J. Biochem. Pharmacol. (2004) [Pubmed]
  3. Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11. Meloni, I., Rubegni, P., De Aloe, G., Bruttini, M., Pianigiani, E., Cusano, R., Seri, M., Mondillo, S., Federico, A., Bardelli, A.M., Andreassi, L., Fimiani, M., Renieri, A. Hum. Mutat. (2001) [Pubmed]
  4. Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. Norris, M.D., Bordow, S.B., Marshall, G.M., Haber, P.S., Cohn, S.L., Haber, M. N. Engl. J. Med. (1996) [Pubmed]
  5. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Roelofsen, H., Vos, T.A., Schippers, I.J., Kuipers, F., Koning, H., Moshage, H., Jansen, P.L., Müller, M. Gastroenterology (1997) [Pubmed]
  6. Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products. Sultana, R., Butterfield, D.A. Neurochem. Res. (2004) [Pubmed]
  7. War games: using MRP (material requirements planning) audits to pinpoint problems and keep the competitive edge. Porter, S.H., Yocus, T.E. Hospital materiel management quarterly. (1994) [Pubmed]
  8. If I could do it all over again. Hauser, C. Hospital materiel management quarterly. (1994) [Pubmed]
  9. Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. Schumacher, M.A., Karamooz, E., Zíková, A., Trantírek, L., Lukes, J. Cell (2006) [Pubmed]
  10. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Robbiani, D.F., Finch, R.A., Jäger, D., Muller, W.A., Sartorelli, A.C., Randolph, G.J. Cell (2000) [Pubmed]
  11. ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Bronger, H., König, J., Kopplow, K., Steiner, H.H., Ahmadi, R., Herold-Mende, C., Keppler, D., Nies, A.T. Cancer Res. (2005) [Pubmed]
  12. Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Bordow, S.B., Haber, M., Madafiglio, J., Cheung, B., Marshall, G.M., Norris, M.D. Cancer Res. (1994) [Pubmed]
  13. Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required. Leslie, E.M., Haimeur, A., Waalkes, M.P. J. Biol. Chem. (2004) [Pubmed]
  14. Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells. Abe, T., Hasegawa, S., Taniguchi, K., Yokomizo, A., Kuwano, T., Ono, M., Mori, T., Hori, S., Kohno, K., Kuwano, M. Int. J. Cancer (1994) [Pubmed]
  15. Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1. Tang, R., Faussat, A.M., Majdak, P., Perrot, J.Y., Chaoui, D., Legrand, O., Marie, J.P. Leukemia (2004) [Pubmed]
  16. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Mitra, P., Oskeritzian, C.A., Payne, S.G., Beaven, M.A., Milstien, S., Spiegel, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  17. Regulation of Function by Dimerization through the Amino-terminal Membrane-spanning Domain of Human ABCC1/MRP1. Yang, Y., Liu, Y., Dong, Z., Xu, J., Peng, H., Liu, Z., Zhang, J.T. J. Biol. Chem. (2007) [Pubmed]
  18. Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions. Koike, K., Conseil, G., Leslie, E.M., Deeley, R.G., Cole, S.P. J. Biol. Chem. (2004) [Pubmed]
  19. GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. Mao, Q., Qiu, W., Weigl, K.E., Lander, P.A., Tabas, L.B., Shepard, R.L., Dantzig, A.H., Deeley, R.G., Cole, S.P. J. Biol. Chem. (2002) [Pubmed]
  20. The Amino Terminus of the Human Multidrug Resistance Transporter ABCC1 Has a U-shaped Folding with a Gating Function. Chen, Q., Yang, Y., Li, L., Zhang, J.T. J. Biol. Chem. (2006) [Pubmed]
  21. Dendritic Cells Require Multidrug Resistance Protein 1 (ABCC1) Transporter Activity for Differentiation. van de Ven, R., de Jong, M.C., Reurs, A.W., Schoonderwoerd, A.J., Jansen, G., Hooijberg, J.H., Scheffer, G.L., de Gruijl, T.D., Scheper, R.J. J. Immunol. (2006) [Pubmed]
  22. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Paulusma, C.C., Bosma, P.J., Zaman, G.J., Bakker, C.T., Otter, M., Scheffer, G.L., Scheper, R.J., Borst, P., Oude Elferink, R.P. Science (1996) [Pubmed]
  23. Tumor necrosis factor-alpha and expression of the multidrug resistance-associated genes LRP and MRP. Stein, U., Walther, W., Laurencot, C.M., Scheffer, G.L., Scheper, R.J., Shoemaker, R.H. J. Natl. Cancer Inst. (1997) [Pubmed]
  24. Role of the NH2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking. Westlake, C.J., Cole, S.P., Deeley, R.G. Mol. Biol. Cell (2005) [Pubmed]
  25. Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1). Payen, L., Gao, M., Westlake, C., Theis, A., Cole, S.P., Deeley, R.G. Mol. Pharmacol. (2005) [Pubmed]
  26. Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1). Chearwae, W., Wu, C.P., Chu, H.Y., Lee, T.R., Ambudkar, S.V., Limtrakul, P. Cancer Chemother. Pharmacol. (2006) [Pubmed]
  27. Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease. Blokzijl, H., van Steenpaal, A., Vander Borght, S., Bok, L.I., Libbrecht, L., Tamminga, M., Geuken, M., Roskams, T.A., Dijkstra, G., Moshage, H., Jansen, P.L., Faber, K.N. J. Biol. Chem. (2008) [Pubmed]
  28. Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population. Yin, J.Y., Huang, Q., Yang, Y., Zhang, J.T., Zhong, M.Z., Zhou, H.H., Liu, Z.Q. Pharmacogenet. Genomics (2009) [Pubmed]
  29. Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters. Conseil, G., Deeley, R.G., Cole, S.P. Pharmacogenet. Genomics (2005) [Pubmed]
  30. Circumvention of multidrug resistance in genitourinary tumors. van Brussel, J.P., Mickisch, G.H. International journal of urology : official journal of the Japanese Urological Association. (1998) [Pubmed]
  31. Decreased polyphenol transport across cultured intestinal cells by a salivary proline-rich protein. Cai, K., Hagerman, A.E., Minto, R.E., Bennick, A. Biochem. Pharmacol. (2006) [Pubmed]
  32. Preferential efflux by P-glycoprotein, but not MRP1, of compounds containing a free electron donor amine. Salerno, M., Przewloka, T., Fokt, I., Priebe, W., Garnier-Suillerot, A. Biochem. Pharmacol. (2002) [Pubmed]
  33. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Lee, K., Belinsky, M.G., Bell, D.W., Testa, J.R., Kruh, G.D. Cancer Res. (1998) [Pubmed]
  34. Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells. Pascolo, L., Fernetti, C., Pirulli, D., Crovella, S., Amoroso, A., Tiribelli, C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  35. MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma. Manohar, C.F., Bray, J.A., Salwen, H.R., Madafiglio, J., Cheng, A., Flemming, C., Marshall, G.M., Norris, M.D., Haber, M., Cohn, S.L. Oncogene (2004) [Pubmed]
  36. Substrates of multidrug resistance-associated proteins block the cystic fibrosis transmembrane conductance regulator chloride channel. Linsdell, P., Hanrahan, J.W. Br. J. Pharmacol. (1999) [Pubmed]
  37. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. Belinsky, M.G., Bain, L.J., Balsara, B.B., Testa, J.R., Kruh, G.D. J. Natl. Cancer Inst. (1998) [Pubmed]
  38. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Kool, M., de Haas, M., Scheffer, G.L., Scheper, R.J., van Eijk, M.J., Juijn, J.A., Baas, F., Borst, P. Cancer Res. (1997) [Pubmed]
  39. Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Morrow, C.S., Peklak-Scott, C., Bishwokarma, B., Kute, T.E., Smitherman, P.K., Townsend, A.J. Mol. Pharmacol. (2006) [Pubmed]
  40. Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Nies, A.T., Jedlitschky, G., König, J., Herold-Mende, C., Steiner, H.H., Schmitt, H.P., Keppler, D. Neuroscience (2004) [Pubmed]
  41. Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833. Beketic-Oreskovic, L., Durán, G.E., Chen, G., Dumontet, C., Sikic, B.I. J. Natl. Cancer Inst. (1995) [Pubmed]
  42. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Rao, V.V., Dahlheimer, J.L., Bardgett, M.E., Snyder, A.Z., Finch, R.A., Sartorelli, A.C., Piwnica-Worms, D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  43. The structure of the multidrug resistance protein 1 (MRP1/ABCC1). crystallization and single-particle analysis. Rosenberg, M.F., Mao, Q., Holzenburg, A., Ford, R.C., Deeley, R.G., Cole, S.P. J. Biol. Chem. (2001) [Pubmed]
WikiGenes - Universities