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Chemical Compound Review

PAI-2     N-(2-oxooxolan-3-yl)butanamide

Synonyms: SureCN787006, CPD-10784, AC1L9ENE, LMFA08030002, 09945_FLUKA, ...
 
 
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Disease relevance of C11837

  • Such is the case in the opportunistic human pathogen Pseudomonas aeruginosa, which contains two quorum sensing systems (las and rhl) that operate via the autoinducers, N-(3-oxododecanoyl)-L-homoserine lactone and N-butyryl-L-homoserine lactone [1].
 

High impact information on C11837

 

Biological context of C11837

 

Associations of C11837 with other chemical compounds

 

Gene context of C11837

  • Expression of the aiiA homologue from isolate A24 in P. aeruginosa PAO1 reduced the amount of the quorum sensing signal N-oxododecanoyl-L-homoserine lactone and completely prevented the accumulation of the second AHL signal, N-butyryl-L-homoserine lactone [10].

References

  1. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Pesci, E.C., Milbank, J.B., Pearson, J.P., McKnight, S., Kende, A.S., Greenberg, E.P., Iglewski, B.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa. Calfee, M.W., Coleman, J.P., Pesci, E.C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide. Hassett, D.J., Ma, J.F., Elkins, J.G., McDermott, T.R., Ochsner, U.A., West, S.E., Huang, C.T., Fredericks, J., Burnett, S., Stewart, P.S., McFeters, G., Passador, L., Iglewski, B.H. Mol. Microbiol. (1999) [Pubmed]
  4. Solubility and bioactivity of the Pseudomonas quinolone signal are increased by a Pseudomonas aeruginosa-produced surfactant. Calfee, M.W., Shelton, J.G., McCubrey, J.A., Pesci, E.C. Infect. Immun. (2005) [Pubmed]
  5. Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Erickson, D.L., Endersby, R., Kirkham, A., Stuber, K., Vollman, D.D., Rabin, H.R., Mitchell, I., Storey, D.G. Infect. Immun. (2002) [Pubmed]
  6. Inhibition of quorum sensing by a Pseudomonas aeruginosa dksA homologue. Branny, P., Pearson, J.P., Pesci, E.C., Köhler, T., Iglewski, B.H., Van Delden, C. J. Bacteriol. (2001) [Pubmed]
  7. The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase. Reimmann, C., Beyeler, M., Latifi, A., Winteler, H., Foglino, M., Lazdunski, A., Haas, D. Mol. Microbiol. (1997) [Pubmed]
  8. A quorum-sensing autoinducer enhances the mexAB-oprM efflux-pump expression without the MexR-mediated regulation in Pseudomonas aeruginosa. Sawada, I., Maseda, H., Nakae, T., Uchiyama, H., Nomura, N. Microbiol. Immunol. (2004) [Pubmed]
  9. Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis. Hoang, T.T., Schweizer, H.P. J. Bacteriol. (1999) [Pubmed]
  10. Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1. Reimmann, C., Ginet, N., Michel, L., Keel, C., Michaux, P., Krishnapillai, V., Zala, M., Heurlier, K., Triandafillu, K., Harms, H., Défago, G., Haas, D. Microbiology (Reading, Engl.) (2002) [Pubmed]
 
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