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Gene Review

gacA  -  response regulator GacA

Pseudomonas aeruginosa PAO1

 
 
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Disease relevance of gacA

 

High impact information on gacA

  • Mutations in the UCBPP-PA14 toxA, plcS, and gacA genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals [2].
  • Three of the TnphoA mutants corresponded to the known virulence-related genes lasR, gacA, and lemA [3].
  • Amplification of gacA on a multicopy plasmid caused precocious and enhanced production of BHL, RhIR and LasR [1].
  • In parallel, the gacA gene dosage markedly influenced the BHL/RhIR-dependent formation of the cytotoxic compounds pyocyanin and cyanide and the exoenzyme lipase [1].
  • An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD) [4].
 

Biological context of gacA

 

Associations of gacA with chemical compounds

  • The expression of the gacA mRNA in C1 (pgacA) was detected [5].
 

Analytical, diagnostic and therapeutic context of gacA

References

  1. The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase. Reimmann, C., Beyeler, M., Latifi, A., Winteler, H., Foglino, M., Lazdunski, A., Haas, D. Mol. Microbiol. (1997) [Pubmed]
  2. Common virulence factors for bacterial pathogenicity in plants and animals. Rahme, L.G., Stevens, E.J., Wolfort, S.F., Shao, J., Tompkins, R.G., Ausubel, F.M. Science (1995) [Pubmed]
  3. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Tan, M.W., Rahme, L.G., Sternberg, J.A., Tompkins, R.G., Ausubel, F.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa. Kay, E., Humair, B., Dénervaud, V., Riedel, K., Spahr, S., Eberl, L., Valverde, C., Haas, D. J. Bacteriol. (2006) [Pubmed]
  5. Pathogenicity of gacA mutant of Pseudomonas aeruginosa PA01 in the silkworm, Bombyx mori. Chieda, Y., Iiyama, K., Yasunaga-Aoki, C., Lee, J.M., Kusakabe, T., Shimizu, S. FEMS Microbiol. Lett. (2005) [Pubmed]
  6. Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Parkins, M.D., Ceri, H., Storey, D.G. Mol. Microbiol. (2001) [Pubmed]
 
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