The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

gacA  -  response regulator GacA

Pseudomonas aeruginosa PAO1

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of gacA


High impact information on gacA

  • Mutations in the UCBPP-PA14 toxA, plcS, and gacA genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals [2].
  • Three of the TnphoA mutants corresponded to the known virulence-related genes lasR, gacA, and lemA [3].
  • Amplification of gacA on a multicopy plasmid caused precocious and enhanced production of BHL, RhIR and LasR [1].
  • In parallel, the gacA gene dosage markedly influenced the BHL/RhIR-dependent formation of the cytotoxic compounds pyocyanin and cyanide and the exoenzyme lipase [1].
  • An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD) [4].

Biological context of gacA


Associations of gacA with chemical compounds

  • The expression of the gacA mRNA in C1 (pgacA) was detected [5].

Analytical, diagnostic and therapeutic context of gacA


  1. The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase. Reimmann, C., Beyeler, M., Latifi, A., Winteler, H., Foglino, M., Lazdunski, A., Haas, D. Mol. Microbiol. (1997) [Pubmed]
  2. Common virulence factors for bacterial pathogenicity in plants and animals. Rahme, L.G., Stevens, E.J., Wolfort, S.F., Shao, J., Tompkins, R.G., Ausubel, F.M. Science (1995) [Pubmed]
  3. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Tan, M.W., Rahme, L.G., Sternberg, J.A., Tompkins, R.G., Ausubel, F.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa. Kay, E., Humair, B., Dénervaud, V., Riedel, K., Spahr, S., Eberl, L., Valverde, C., Haas, D. J. Bacteriol. (2006) [Pubmed]
  5. Pathogenicity of gacA mutant of Pseudomonas aeruginosa PA01 in the silkworm, Bombyx mori. Chieda, Y., Iiyama, K., Yasunaga-Aoki, C., Lee, J.M., Kusakabe, T., Shimizu, S. FEMS Microbiol. Lett. (2005) [Pubmed]
  6. Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Parkins, M.D., Ceri, H., Storey, D.G. Mol. Microbiol. (2001) [Pubmed]
WikiGenes - Universities