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Chemical Compound Review:

droxidopa (2R,3R)-2-amino-3-(3,4- dihydroxyphenyl)-3...

Synonyms: Droxydopa, DOPS, SureCN129757, AC1L9FFX, DB06262, ...

Mathias, C.J. et al., Sato, K. et al., Kondo, T.

Mathias, Senard, Braune, Watson, Aragishi, Keeling, Taylor,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of droxidopa

L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure [1].
After treatment with droxidopa "a sympathomimetic drug", ambulatory blood pressure gradually increased and hyponatremia disappeared [2].

High impact information on droxidopa

The effects of four drugs (donepezil vs droxidopa and amantadine vs selegiline) were investigated by crossover design [3].

References

L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-center, dose-ranging study in multiple system atrophy and pure autonomic failure. Mathias, C.J., Senard, J.M., Braune, S., Watson, L., Aragishi, A., Keeling, J.E., Taylor, M.D. Clin. Auton. Res. (2001) [Pubmed]
A case of syndrome of inappropriate secretion of antidiuretic hormone associated with diabetes mellitus. Sato, K., Kimura, T., Ota, K., Shoji, M., Inoue, M., Ohta, M., Yamamoto, T., Chiba, T., Saeki, S., Abe, K. Endocrinol. Jpn. (1991) [Pubmed]
Drug intervention for freezing of gait resistant to dopaminergic therapy: A pilot study. Kondo, T. Parkinsonism Relat. Disord. (2006) [Pubmed]

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