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MeSH Review

Autonomic Nervous System Diseases

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Disease relevance of Autonomic Nervous System Diseases


Psychiatry related information on Autonomic Nervous System Diseases


High impact information on Autonomic Nervous System Diseases

  • CONCLUSIONS: Seropositivity for antibodies that bind to or block ganglionic acetylcholine receptors identifies patients with various forms of autoimmune autonomic neuropathy and distinguishes these disorders from other types of dysautonomia [9].
  • We examined sympathetic innervation of the heart in patients with acquired, idiopathic dysautonomias using thoracic positron-emission tomography and assessments of the entry rate of the sympathetic neurotransmitter norepinephrine into the cardiac venous drainage (cardiac norepinephrine spillover) [10].
  • METHODS: Clonidine is a centrally active alpha 2-adrenoceptor agonist that raises concentrations of GH in serum in healthy people and those with pure autonomic failure (with peripheral lesions), but not in those with MSA (with a central autonomic deficit) [2].
  • The role of this growth factor in dysautonomia has been difficult to resolve as there is no known source of authentic human beta-NGF [11].
  • Dystrophic neurites containing neuropeptide Y occur in human sympathetic ganglia during aging, diabetes, and dysautonomia [12].

Chemical compound and disease context of Autonomic Nervous System Diseases


Biological context of Autonomic Nervous System Diseases


Anatomical context of Autonomic Nervous System Diseases


Gene context of Autonomic Nervous System Diseases

  • Linkage analysis excluded a role for NGFR in this disease with odds of greater than 10(6):1 against the dysautonomia gene being within 1 centiMorgan of the mutation [26].
  • In addition, no DBH mutation was found that distinguished autonomic disease patients from controls, suggesting that genetic variants of the DBH gene are not associated with the autonomic diseases OI, PAF, and MSA [27].
  • Disorders of the autonomic nervous system: Part 2. Investigation and treatment [28].
  • We evaluated cardiovascular responses to autonomic stimuli in 118 patients with symptoms of dysautonomia, 78 of whom had MVP, and 40 of whom did not, to determine if unique patterns of these responses distinguished patients in one symptomatic subgroup from another [29].
  • Identification of a renin threshold and its relationship to salt intake in a patient with pure autonomic failure [30].

Analytical, diagnostic and therapeutic context of Autonomic Nervous System Diseases


  1. Deficient sympathetic nervous response in familial dysautonomia. Ziegler, M.G., Lake, C.R., Kopin, I.J. N. Engl. J. Med. (1976) [Pubmed]
  2. Distinction of idiopathic Parkinson's disease from multiple-system atrophy by stimulation of growth-hormone release with clonidine. Kimber, J.R., Watson, L., Mathias, C.J. Lancet (1997) [Pubmed]
  3. Diarrhea and autonomic dysfunction in a patient with hexosaminidase B deficiency (Sandhoff disease). Modigliani, R., Lemann, M., Melançon, S.B., Mikol, J., Potier, M., Salmeron, M., Said, G., Poitras, P. Gastroenterology (1994) [Pubmed]
  4. Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. Goldstein, D.S., Polinsky, R.J., Garty, M., Robertson, D., Brown, R.T., Biaggioni, I., Stull, R., Kopin, I.J. Ann. Neurol. (1989) [Pubmed]
  5. Dysautonomia in human T-cell lymphotrophic virus type I-associated myelopathy/tropical spastic paraparesis. Alamy, A.H., Menezes, F.B., Leite, A.C., Nascimento, O.M., Araújo, A.Q. Ann. Neurol. (2001) [Pubmed]
  6. Familial neuropathy with dementia, retinitis pigmentosa, and dysautonomia. Ozawa, K., Saida, K., Saida, T., Imoto, K., Nishitani, H. Neurology (1985) [Pubmed]
  7. Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndrome. Reuter, I., Hu, M.T., Andrews, T.C., Brooks, D.J., Clough, C., Chaudhuri, K.R. J. Neurol. Neurosurg. Psychiatr. (2000) [Pubmed]
  8. Cardiac dysautonomia and serotonin plasma levels in Rett syndrome. Guideri, F., Acampa, M., Blardi, P., de Lalla, A., Zappella, M., Hayek, Y. Neuropediatrics. (2004) [Pubmed]
  9. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. Vernino, S., Low, P.A., Fealey, R.D., Stewart, J.D., Farrugia, G., Lennon, V.A. N. Engl. J. Med. (2000) [Pubmed]
  10. Sympathetic cardioneuropathy in dysautonomias. Goldstein, D.S., Holmes, C., Cannon, R.O., Eisenhofer, G., Kopin, I.J. N. Engl. J. Med. (1997) [Pubmed]
  11. Structural gene for beta-nerve growth factor not defective in familial dysautonomia. Breakefield, X.O., Orloff, G., Castiglione, C., Coussens, L., Axelrod, F.B., Ullrich, A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. Neuropeptides in the sympathetic system: presence, plasticity, modulation, and implications. Benarroch, E.E. Ann. Neurol. (1994) [Pubmed]
  13. The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson's disease, studied with PET. Brooks, D.J., Salmon, E.P., Mathias, C.J., Quinn, N., Leenders, K.L., Bannister, R., Marsden, C.D., Frackowiak, R.S. Brain (1990) [Pubmed]
  14. Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs. Davies, A.O., Su, C.J., Balasubramanyam, A., Codina, J., Birnbaumer, L. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  15. Selegiline diminishes cardiovascular autonomic responses in Parkinson's disease. Turkka, J., Suominen, K., Tolonen, U., Sotaniemi, K., Myllylä, V.V. Neurology (1997) [Pubmed]
  16. Hypotension-induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure. Kaufmann, H., Oribe, E., Miller, M., Knott, P., Wiltshire-Clement, M., Yahr, M.D. Neurology (1992) [Pubmed]
  17. Autonomic dysfunction in the Lambert-Eaton myasthenic syndrome: serologic and clinical correlates. O'Suilleabhain, P., Low, P.A., Lennon, V.A. Neurology (1998) [Pubmed]
  18. The hypertension of autonomic failure and its treatment. Shannon, J., Jordan, J., Costa, F., Robertson, R.M., Biaggioni, I. Hypertension (1997) [Pubmed]
  19. Plasma norepinephrine responses to head-up tilt are misleading in autonomic failure. Meredith, I.T., Eisenhofer, G., Lambert, G.W., Jennings, G.L., Thompson, J., Esler, M.D. Hypertension (1992) [Pubmed]
  20. Association between supine hypertension and orthostatic hypotension in autonomic failure. Goldstein, D.S., Pechnik, S., Holmes, C., Eldadah, B., Sharabi, Y. Hypertension (2003) [Pubmed]
  21. Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotension. Jordan, J., Biaggioni, I. Journal of clinical hypertension (Greenwich, Conn.) (2002) [Pubmed]
  22. Accumulation of alpha-synuclein in autonomic nerves in pure autonomic failure. Kaufmann, H., Hague, K., Perl, D. Neurology (2001) [Pubmed]
  23. CSF acetylcholinesterase levels are reduced in multiple system atrophy with autonomic failure. Polinsky, R.J., Holmes, K.V., Brown, R.T., Weise, V. Neurology (1989) [Pubmed]
  24. Gastrin responses in patients with adrenergic insufficiency. Polinsky, R.J., Taylor, I.L., Weise, V., Kopin, I.J. J. Neurol. Neurosurg. Psychiatr. (1988) [Pubmed]
  25. Imaging of the autonomic nervous system: focus on cardiac sympathetic innervation. Goldstein, D.S. Seminars in neurology. (2003) [Pubmed]
  26. DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia. Breakefield, X.O., Ozelius, L., Bothwell, M.A., Chao, M.V., Axelrod, F., Kramer, P.L., Kidd, K.K., Lanahan, A.A., Johnson, D.E., Ross, A.H. Mol. Biol. Med. (1986) [Pubmed]
  27. Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy. Cho, S., Kim, C.H., Cubells, J.F., Zabetian, C.P., Hwang, D.Y., Kim, J.W., Cohen, B.M., Biaggioni, I., Robertson, D., Kim, K.S. Am. J. Med. Genet. A (2003) [Pubmed]
  28. Disorders of the autonomic nervous system: Part 2. Investigation and treatment. McLeod, J.G., Tuck, R.R. Ann. Neurol. (1987) [Pubmed]
  29. Spectrum of dysautonomia in mitral valvular prolapse. Taylor, A.A., Davies, A.O., Mares, A., Raschko, J., Pool, J.L., Nelson, E.B., Mitchell, J.R. Am. J. Med. (1989) [Pubmed]
  30. Identification of a renin threshold and its relationship to salt intake in a patient with pure autonomic failure. Hohenbleicher, H., Klosterman, F., Schorr, U., Seyfert, S., Persson, P.B., Sharma, A.M. Hypertension (1997) [Pubmed]
  31. Heart rate spectral analysis, cardiac norepinephrine spillover, and muscle sympathetic nerve activity during human sympathetic nervous activation and failure. Kingwell, B.A., Thompson, J.M., Kaye, D.M., McPherson, G.A., Jennings, G.L., Esler, M.D. Circulation (1994) [Pubmed]
  32. Regional origins of 3-methoxy-4-hydroxyphenylglycol in plasma: effects of chronic sympathetic nervous activation and denervation, and acute reflex sympathetic stimulation. Lambert, G.W., Kaye, D.M., Vaz, M., Cox, H.S., Turner, A.G., Jennings, G.L., Esler, M.D. J. Auton. Nerv. Syst. (1995) [Pubmed]
  33. Blood pressure and heart rate are increased by AF-DX 116, a selective M2 antagonist, in autonomic imbalanced and hypotensive rats caused by repeated cold stress. Hata, T., Itoh, E., Funakami, Y., Ishida, K., Uchida, S. Jpn. J. Pharmacol. (2001) [Pubmed]
  34. Dysautonomia syndrome in the acute recovery phase after traumatic brain injury: relief with intrathecal Baclofen therapy. Cuny, E., Richer, E., Castel, J.P. Brain injury : [BI]. (2001) [Pubmed]
  35. Catecholamine levels in the brain of SART (repeated cold)-stressed rats. Hata, T., Kita, T., Kamanaka, Y., Honda, S., Kakehi, K., Kawabata, A., Itoh, E. Journal of autonomic pharmacology. (1987) [Pubmed]
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