Chemical Compound Review:
donepezil 2-[(1-benzyl-4- piperidyl)methyl]-5,6...
Synonyms:
donepezilo, Donaz, Eranz, donepezilum, CHEMBL502, ...
Kuhl,
Hallett,
Rigaud,
Bartenstein,
Silman,
Grundman,
Knechtelsdorfer,
Babiloni,
Mayerhofer,
Foster,
Soininen,
Phipps,
Aisen,
Clark,
Weisler,
Martin Dichgans,
Hugh S. Markus,
Stephen Salloway,
Auli Verkkoniemi,
Margaret Moline,
Qin Wang,
Holly Posner,
Hugues S. Chabriat,
Teipel,
Kryger,
Sussman,
Mori,
Mintzer,
Bennett,
Traykov,
Petersen,
Chisari,
Platania,
Frisoni,
Winblad,
Grundman,
Moulin,
Kazui,
Schultz,
Jin,
Rogers,
Flashman,
Wishart,
Matsumoto,
Padovani,
Tragl,
Borroni,
Huber,
Ferris,
Nakano,
Subbiah,
Möller,
Mersich,
Del Percio,
Latour,
Charles,
Cattabeni,
Ferri,
Harvey,
Small,
Thal,
Moretti,
Mintzer,
Hashimoto,
Salinari,
Jack,
Zhang,
Rossini,
Perdomo,
Waldemar,
Scheltens,
Drzezga,
Rabin,
Cassetta,
Frey,
Snyder,
Sano,
Dal Forno,
Schwaiger,
Petersen,
Thomas,
Ferreri,
Zanetti,
Kim,
Jack,
Engedal,
Mohs,
Ieni,
Marcello,
Colciaghi,
Obermayr,
Wetterholm,
Wimo,
Forette,
Grafman,
Koeppe,
Rodriguez,
Canonico,
Lanuzza,
Hampel,
Kilbourn,
Galasko,
Kaye,
Yu,
Thal,
Couderc,
Chiechio,
Vancheri,
Modrego,
Cahn-Weiner,
Pascual-Marqui,
Gauthier,
Jann,
Verhey,
Decarli,
Geyer,
Zamrini,
Sortino,
McHugh,
Copani,
Frasca,
Nobili,
van Dyck,
Luca Romani,
Zimmermann,
Doraiswamy,
Yasuda,
Shirley,
Jin,
Salazar,
Mamourian,
Di Luca,
Pharr,
Haglund,
Miniussi,
Minoshima,
Doody,
Krishnan,
Gardoni,
Litvan,
Santulli,
Saykin,
Schafer,
Mulnard,
- Urinary incontinence: an unrecognised adverse effect with donepezil. Hashimoto, M., Imamura, T., Tanimukai, S., Kazui, H., Mori, E. Lancet (2000)
- Donepezil for Down's syndrome. Kishnani, P.S., Spiridigliozzi, G.A., Heller, J.H., Sullivan, J.A., Doraiswamy, P.M., Krishnan, K.R. The American journal of psychiatry. (2001)
- Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease? Hashimoto, M., Kazui, H., Matsumoto, K., Nakano, Y., Yasuda, M., Mori, E. The American journal of psychiatry. (2005)
- Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy. Litvan, I., Phipps, M., Pharr, V.L., Hallett, M., Grafman, J., Salazar, A. Neurology (2001)
- Treatment of tardive dyskinesia with donepezil. Caroff, S.N., Campbell, E.C., Havey, J.C., Sullivan, K.A., Katz, I.R., Mann, S.C. The Journal of clinical psychiatry. (2001)
- Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. Dichgans, M., Markus, H.S., Salloway, S., Verkkoniemi, A., Moline, M., Wang, Q., Posner, H., Chabriat, H.S. Lancet. Neurol (2008)
- Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. Saykin, A.J., Wishart, H.A., Rabin, L.A., Flashman, L.A., McHugh, T.L., Mamourian, A.C., Santulli, R.B. Brain (2004)
- Treating visual hallucinations with donepezil. Burke, W.J., Roccaforte, W.H., Wengel, S.P. The American journal of psychiatry. (1999)
- A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD. Winblad, B., Engedal, K., Soininen, H., Verhey, F., Waldemar, G., Wimo, A., Wetterholm, A.L., Zhang, R., Haglund, A., Subbiah, P. Neurology (2001)
- Donepezil in treatment-resistant bipolar disorder. Burt, T., Sachs, G.S., Demopulos, C. Biol. Psychiatry (1999)
- Suppression of methamphetamine-seeking behavior by nicotinic agonists. Hiranita, T., Nawata, Y., Sakimura, K., Anggadiredja, K., Yamamoto, T. Proc. Natl. Acad. Sci. U.S.A. (2006)
- In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Kuhl, D.E., Koeppe, R.A., Snyder, S.E., Minoshima, S., Frey, K.A., Kilbourn, M.R. Ann. Neurol. (2006)
- Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex. Kuhl, D.E., Minoshima, S., Frey, K.A., Foster, N.L., Kilbourn, M.R., Koeppe, R.A. Ann. Neurol. (2000)
- Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat. Misane, I., Ogren, S.O. Neuropsychopharmacology (2003)
- Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Decarli, C., Frisoni, G.B., Clark, C.M., Harvey, D., Grundman, M., Petersen, R.C., Thal, L.J., Jin, S., Jack, C.R., Scheltens, P. Arch. Neurol. (2007)
- Combination of donepezil and gabapentin for behavioral disorders in Alzheimer's disease. Dallocchio, C., Buffa, C., Mazzarello, P. The Journal of clinical psychiatry. (2000)
- Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. Meunier, J., Ieni, J., Maurice, T. J. Pharmacol. Exp. Ther. (2006)
- Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Takada-Takatori, Y., Kume, T., Sugimoto, M., Katsuki, H., Sugimoto, H., Akaike, A. Neuropharmacology (2006)
- The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Harel, M., Hyatt, J.L., Brumshtein, B., Morton, C.L., Yoon, K.J., Wadkins, R.M., Silman, I., Sussman, J.L., Potter, P.M. Mol. Pharmacol. (2005)
- Presence or absence of at least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease. Rigaud, A.S., Traykov, L., Latour, F., Couderc, R., Moulin, F., Forette, F. Pharmacogenetics (2002)
- Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. Takada, Y., Yonezawa, A., Kume, T., Katsuki, H., Kaneko, S., Sugimoto, H., Akaike, A. J. Pharmacol. Exp. Ther. (2003)
- Novel neuronal targets for the acetylcholinesterase inhibitor donepezil. Sortino, M.A., Frasca, G., Chisari, M., Platania, P., Chiechio, S., Vancheri, C., Copani, A., Canonico, P.L. Neuropharmacology (2004)
- Dementia with Lewy bodies: response of delirium-like features to donepezil. Kaufer, D.I., Catt, K.E., Lopez, O.L., DeKosky, S.T. Neurology (1998)
- Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease. Nakano, S., Asada, T., Matsuda, H., Uno, M., Takasaki, M. J. Nucl. Med. (2001)
- Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Jann, M.W., Shirley, K.L., Small, G.W. Clinical pharmacokinetics. (2002)
- Effects of donepezil on cortical metabolic response to activation during (18)FDG-PET in Alzheimer's disease: a double-blind cross-over trial. Teipel, S.J., Drzezga, A., Bartenstein, P., Möller, H.J., Schwaiger, M., Hampel, H. Psychopharmacology (Berl.) (2006)
- Reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635. Balducci, C., Nurra, M., Pietropoli, A., Samanin, R., Carli, M. Psychopharmacology (Berl.) (2003)
- Diagnosis, management, and treatment of Alzheimer disease: a guide for the internist. Richards, S.S., Hendrie, H.C. Arch. Intern. Med. (1999)
- Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group. Rogers, S.L., Doody, R.S., Mohs, R.C., Friedhoff, L.T. Arch. Intern. Med. (1998)
- The effect of drugs for Alzheimer disease assessed by means of neuroradiological techniques. Modrego, P.J. Current medicinal chemistry (2006)
- Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET. Shinotoh, H., Aotsuka, A., Fukushi, K., Nagatsuka, S., Tanaka, N., Ota, T., Tanada, S., Irie, T. Neurology (2001)
- Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Grundman, M., Petersen, R.C., Ferris, S.H., Thomas, R.G., Aisen, P.S., Bennett, D.A., Foster, N.L., Jack, C.R., Galasko, D.R., Doody, R., Kaye, J., Sano, M., Mohs, R., Gauthier, S., Kim, H.T., Jin, S., Schultz, A.N., Schafer, K., Mulnard, R., van Dyck, C.H., Mintzer, J., Zamrini, E.Y., Cahn-Weiner, D., Thal, L.J. Arch. Neurol. (2004)
- Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. Zimmermann, M., Gardoni, F., Marcello, E., Colciaghi, F., Borroni, B., Padovani, A., Cattabeni, F., Di Luca, M. J. Neurochem. (2004)
- The anti-amnesic and neuroprotective effects of donepezil against amyloid beta(25-35) peptide-induced toxicity in mice involve an interaction with the sigma(1) receptor. Meunier, J., Ieni, J., Maurice, T. Br. J. Pharmacol. (2006)
- ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model. Borroni, B., Colciaghi, F., Pastorino, L., Archetti, S., Corsini, P., Cattabeni, F., Di Luca, M., Padovani, A. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2002)
- The age-related down-regulation of the growth hormone/insulin-like growth factor-1 axis in the elderly male is reversed considerably by donepezil, a drug for Alzheimer's disease. Obermayr, R.P., Mayerhofer, L., Knechtelsdorfer, M., Mersich, N., Huber, E.R., Geyer, G., Tragl, K.H. Exp. Gerontol. (2005)
- Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Kryger, G., Silman, I., Sussman, J.L. Structure (1999)
- Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease: Responders vs. Non-Responders. Babiloni, C., Cassetta, E., Dal Forno, G., Del Percio, C., Ferreri, F., Ferri, R., Lanuzza, B., Miniussi, C., Moretti, D.V., Nobili, F., Pascual-Marqui, R.D., Rodriguez, G., Luca Romani, G., Salinari, S., Zanetti, O., Rossini, P.M. Neuroimage (2006)
- Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. Krishnan, K.R., Charles, H.C., Doraiswamy, P.M., Mintzer, J., Weisler, R., Yu, X., Perdomo, C., Ieni, J.R., Rogers, S. The American journal of psychiatry. (2003)