Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

acetyl-CoA [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-2...

Synonyms: AcCoA, S-acetate, ac-CoA, ac-S-CoA, S-acetyl-CoA, ...

de Carvalho, L.P. et al., Seravalli, J. et al., Shirota, F.N. et al.

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Disease relevance of ACETYL COENZYME A

Mycobacterium tuberculosis alpha-isopropylmalate synthase (MtIPMS) catalyzes the condensation of acetyl-coenzyme A (AcCoA) with alpha-ketoisovalerate (alpha-KIV) and the subsequent hydrolysis of alpha-isopropylmalyl-CoA to generate the products CoA and alpha-isopropylmalate (alpha-IPM) [1].

High impact information on ACETYL COENZYME A

Thus, the enzyme responsible for this biotransformation of cyanamide is an acetyl-S-CoA-dependent N-acetyltransferase [2].

Biological context of ACETYL COENZYME A

MtIPMS requires two catalytic bases for maximal activity (both with pK(a) values of ca. 6.7), and we suggest that one catalyzes deprotonation and enolization of AcCoA and the other activates the water molecule involved in the hydrolysis of alpha-isopropylmalyl-CoA [1].

Associations of ACETYL COENZYME A with other chemical compounds

These results demonstrate that CoA is the last substrate to bind and that CO and the methyl group bind randomly as the first substrate in acetyl-CoA synthesis [3].

References

Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. de Carvalho, L.P., Blanchard, J.S. Biochemistry (2006) [Pubmed]
N-acetylcyanamide, the major urinary metabolite of cyanamide in rat, rabbit, dog, and man. Shirota, F.N., Nagasawa, H.T., Kwon, C.H., DeMaster, E.G. Drug Metab. Dispos. (1984) [Pubmed]
Pulse-chase studies of the synthesis of acetyl-CoA by carbon monoxide dehydrogenase/acetyl-CoA synthase: evidence for a random mechanism of methyl and carbonyl addition. Seravalli, J., Ragsdale, S.W. J. Biol. Chem. (2008) [Pubmed]

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