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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

acetyl-CoA     [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-2...

Synonyms: AcCoA, S-acetate, ac-CoA, ac-S-CoA, S-acetyl-CoA, ...
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Disease relevance of ACETYL COENZYME A


High impact information on ACETYL COENZYME A


Biological context of ACETYL COENZYME A

  • MtIPMS requires two catalytic bases for maximal activity (both with pK(a) values of ca. 6.7), and we suggest that one catalyzes deprotonation and enolization of AcCoA and the other activates the water molecule involved in the hydrolysis of alpha-isopropylmalyl-CoA [1].

Associations of ACETYL COENZYME A with other chemical compounds

  • These results demonstrate that CoA is the last substrate to bind and that CO and the methyl group bind randomly as the first substrate in acetyl-CoA synthesis [3].


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