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Chemical Compound Review

ACMC-1BNF9     2-hydroxy-2-propan-2-yl- butanedioic acid

Synonyms: AG-F-08155, CHEBI:28635, bmse000982, bmse001025, AC1Q5SNJ, ...
 
 
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Disease relevance of 2-isopropylmalate

 

Psychiatry related information on 2-isopropylmalate

 

High impact information on 2-isopropylmalate

 

Chemical compound and disease context of 2-isopropylmalate

 

Biological context of 2-isopropylmalate

 

Anatomical context of 2-isopropylmalate

 

Associations of 2-isopropylmalate with other chemical compounds

 

Gene context of 2-isopropylmalate

 

Analytical, diagnostic and therapeutic context of 2-isopropylmalate

References

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  5. The response time of transcription and translation of the leu-2 gene of Neurospora to its inducer, alpha-isopropylmalate, approaches the permissible minimum. Mary, A., Kidd, G.L., Gross, S.R. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  6. In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Sze, J.Y., Woontner, M., Jaehning, J.A., Kohlhaw, G.B. Science (1992) [Pubmed]
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  9. Yeast alpha-isopropylmalate isomerase. Factors affecting stability and enzyme activity. Bigelis, R., Umbarger, H.E. J. Biol. Chem. (1976) [Pubmed]
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  12. Alpha-isopropylmalate synthase from Alcaligenes eutrophus H 16. III. Endproduct inhibition and its relief by valine and isoleucine. Wiegel, J., Schlegel, H.G. Arch. Microbiol. (1977) [Pubmed]
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  17. Comparative genomics of transcriptional regulation in yeasts and its application to identification of a candidate alpha-isopropylmalate transporter. Kovaleva, G.Y., Bazykin, G.A., Brudno, M., Gelfand, M.S. Journal of bioinformatics and computational biology (2006) [Pubmed]
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  21. Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Koon, N., Squire, C.J., Baker, E.N. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  22. The Saccharomyces cerevisiae Leu3 protein activates expression of GDH1, a key gene in nitrogen assimilation. Hu, Y., Cooper, T.G., Kohlhaw, G.B. Mol. Cell. Biol. (1995) [Pubmed]
  23. Cloning of leucine genes of alkalophilic Bacillus No. 221 in E. coli and B. subtilis. Honda, H., Kato, C., Kudo, T., Horikoshi, K. J. Biochem. (1984) [Pubmed]
  24. Salmonella typhimurium newD and Escherichia coli leuC genes code for a functional isopropylmalate isomerase in Salmonella typhimurium-Escherichia coli hybrids. Fultz, P.N., Kwoh, D.Y., Kemper, J. J. Bacteriol. (1979) [Pubmed]
 
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