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Chemical Compound Review:

Streptothricin [5-(3,6- diaminohexanoylamino)-4- hydroxy-2...

Synonyms: AC1L9TQA, AC1Q6GOE, AR-1G4176, 54003-27-9, STREPTOTHRICINS

Hamano, Y. et al., Tietze, E. et al., Ando, T. et al., Böttcher, I. et al., Seltmann, G. et al., et al.

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Disease relevance of STREPTOTHRICINS

Streptothricins (STs) produced by Streptomyces strains are broad-spectrum antibiotics [1].
STs have not been clinically developed due to their toxicities; however, in this study, we showed that hydrolyzed ST-D (ST-D-acid) exhibits potent antibacterial activity even when its toxicity against eukaryotic cells is reduced by SttH [1].
As an important source of streptothricin-resistant Campylobacter strains we localized slurry of swine previously fed with feed containing streptothricins [2].
Nourseothricin, a mixture of several streptothricins, is inactivated by an acetyl transferase produced by Escherichia coli containing the plasmid pIE636 [3].

High impact information on STREPTOTHRICINS

Biosynthesis of streptolidine moiety of streptothricins by Streptomyces noursei JA 3890b [4].
Streptothricin resistance genes related to those present on transposons Tn 1825 and Tn 1826 have been detected by hybridization with the probe sat 1/2 on plasmids isolated a long time ago before the application of streptothricins [5].

Analytical, diagnostic and therapeutic context of STREPTOTHRICINS

On the basis of NMR and fast atom bombardment mass spectrometry (FAB-MS) spectra the antibiotics were identified as N beta-acetylated derivatives of streptothricins E, D and F [6].

References

A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific. Hamano, Y., Matsuura, N., Kitamura, M., Takagi, H. J. Biol. Chem. (2006) [Pubmed]
The occurrence of high-level streptothricin resistance in thermotolerant campylobacters isolated from the slurry of swine and the environment. Böttcher, I., Jacob, J. Zentralbl. Bakteriol. (1992) [Pubmed]
Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase: nature of the inactivated nourseothricin. Seltmann, G., Beer, W. Acta Microbiol. Hung. (1987) [Pubmed]
Biosynthesis of streptolidine moiety of streptothricins by Streptomyces noursei JA 3890b. Gräfe, U., Reinhardt, G., Bocker, H., Thrum, H. J. Antibiot. (1977) [Pubmed]
DNA probes for studying streptothricin resistance evolution in enteric bacteria. Tietze, E., Tschäpe, H., Golubev, A.V. J. Basic Microbiol. (1990) [Pubmed]
New streptothricin-group antibiotics, AN-201 I, II and III. II. Chemical structures. Ando, T., Miyashiro, S., Hirayama, K., Kida, T., Shibai, H., Murai, A., Udaka, S. J. Antibiot. (1987) [Pubmed]

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