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Chemical Compound Review

Apicidin A     (3S,6S,9S,12R)-3-butan-2-yl- 6-(1H-indol-3...

Synonyms: CHEBI:118497, AC1LA3NP
 
 
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Disease relevance of Apicidin A

 

High impact information on Apicidin A

  • Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase [3].
  • Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin [4].
  • We previously reported that apicidin, a novel histone deacetylase inhibitor, inhibited the proliferation of tumor cells via induction of p21(WAF1/Cip1) [5].
  • Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells [6].
  • PURPOSE: Apicidin, a histone deacetylase inhibitor, is a novel cyclic tetrapeptide that exhibits potent antiproliferative activity against various cancer cell lines [6].
 

Biological context of Apicidin A

 

Anatomical context of Apicidin A

 

Gene context of Apicidin A

References

  1. Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. Kwon, S.H., Ahn, S.H., Kim, Y.K., Bae, G.U., Yoon, J.W., Hong, S., Lee, H.Y., Lee, Y.W., Lee, H.W., Han, J.W. J. Biol. Chem. (2002) [Pubmed]
  2. Apicidin, a novel histone deacetylase inhibitor, has profound anti-growth activity in human endometrial and ovarian cancer cells. Ueda, T., Takai, N., Nishida, M., Nasu, K., Narahara, H. Int. J. Mol. Med. (2007) [Pubmed]
  3. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Darkin-Rattray, S.J., Gurnett, A.M., Myers, R.W., Dulski, P.M., Crumley, T.M., Allocco, J.J., Cannova, C., Meinke, P.T., Colletti, S.L., Bednarek, M.A., Singh, S.B., Goetz, M.A., Dombrowski, A.W., Polishook, J.D., Schmatz, D.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Han, J.W., Ahn, S.H., Park, S.H., Wang, S.Y., Bae, G.U., Seo, D.W., Kwon, H.K., Hong, S., Lee, H.Y., Lee, Y.W., Lee, H.W. Cancer Res. (2000) [Pubmed]
  5. Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. Han, J.W., Ahn, S.H., Kim, Y.K., Bae, G.U., Yoon, J.W., Hong, S., Lee, H.Y., Lee, Y.W., Lee, H.W. J. Biol. Chem. (2001) [Pubmed]
  6. Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells. Cheong, J.W., Chong, S.Y., Kim, J.Y., Eom, J.I., Jeung, H.K., Maeng, H.Y., Lee, S.T., Min, Y.H. Clin. Cancer Res. (2003) [Pubmed]
  7. Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor. Kim, J.S., Lee, S., Lee, T., Lee, Y.W., Trepel, J.B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  8. In vitro investigation of the hepatic intrinsic clearance of apicidin, a histone deacetylase inhibitor, in mouse, rat, and human, with correction by nonspecific protein binding. Shin, B.S., Park, E.H., Yoon, C.H., Kim, J., Zee, O., Yoo, S.D. J. Toxicol. Environ. Health Part A (2005) [Pubmed]
  9. Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells. Hong, J., Ishihara, K., Yamaki, K., Hiraizumi, K., Ohno, T., Ahn, J.W., Zee, O., Ohuchi, K. Cancer Lett. (2003) [Pubmed]
  10. Development of a liquid chromatography/electrospray tandem mass spectrometry assay for the quantification of apicidin, a novel histone deacetylase inhibitor, in rat serum: application to a pharmacokinetic study. Shin, B.S., Kim, J., Yoon, C.H., Kim, C.H., Park, E.H., Han, J.W., Yoo, S.D. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
 
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