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Gene Review

Gsn  -  gelsolin

Mus musculus

Synonyms: ADF, Actin-depolymerizing factor, Brevin, Gelsolin, Gsb
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Disease relevance of Gsn

  • We have shown that osteopontin (OP) binding to the alpha(v)beta(3) integrin of osteoclast podosomes stimulated cytoskeletal reorganization and bone resorption by activating a heteromultimeric signaling complex that includes gelsolin, pp(60c-src), and phosphatidylinositol 3'-kinase [1].
  • The Ca2+-sensitive actin-severing protein gelsolin concentrates in the Listeria rocket tails at normal resting [Ca2+]i and disassociates from the tails when [Ca2+]i is lowered [2].
  • We expressed both proteins in Escherichia coli and show that mouse adseverin displays the typical characteristics of all members of the gelsolin family with respect to actin binding (capping, severing, and nucleation) and its regulation by Ca2+ [3].
  • Southern analysis revealed no major mutations in the gelsolin gene of human breast cancer cells [4].
  • Gelsolin was also missing or greatly decreased in 70% of 30 human sporadic, invasive breast carcinomas examined by immunocytochemistry and in 100% of virally induced mouse and chemically induced rat mammary carcinomas evaluated by Northern analysis [4].

Psychiatry related information on Gsn

  • To understand the distinct functions of the closely related actin-severing proteins adseverin and gelsolin, we examined the expression of these proteins in detail during mouse and human development using a new highly sensitive and specific set of antibody reagents [5].

High impact information on Gsn


Chemical compound and disease context of Gsn


Biological context of Gsn


Anatomical context of Gsn

  • Transplantation of GsnWT epithelium into the Gsn-/- fat pad recapitulated the lack of terminal branching seen in Gsn-/- females [12].
  • Lobuloalveolar development was delayed in response to pregnancy in mammary glands of Gsn-/- mice but was otherwise normal [12].
  • Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin [7].
  • Gelsolin was expressed in the distal convoluted tubule, intercalated cells and principal cells of cortical and medullary collecting ducts, and in ureter [5].
  • Here, we report the expression of gelsolin mRNA and protein in the hippocampus following transections of the entorhinal afferents [13].

Associations of Gsn with chemical compounds


Physical interactions of Gsn


Enzymatic interactions of Gsn


Regulatory relationships of Gsn


Other interactions of Gsn


Analytical, diagnostic and therapeutic context of Gsn


  1. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. Chellaiah, M., Kizer, N., Silva, M., Alvarez, U., Kwiatkowski, D., Hruska, K.A. J. Cell Biol. (2000) [Pubmed]
  2. Gelsolin mediates calcium-dependent disassembly of Listeria actin tails. Larson, L., Arnaudeau, S., Gibson, B., Li, W., Krause, R., Hao, B., Bamburg, J.R., Lew, D.P., Demaurex, N., Southwick, F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes. Robbens, J., Louahed, J., De Pestel, K., Van Colen, I., Ampe, C., Vandekerckhove, J., Renauld, J.C. Mol. Cell. Biol. (1998) [Pubmed]
  4. Widespread loss of gelsolin in breast cancers of humans, mice, and rats. Asch, H.L., Head, K., Dong, Y., Natoli, F., Winston, J.S., Connolly, J.L., Asch, B.B. Cancer Res. (1996) [Pubmed]
  5. The actin-binding proteins adseverin and gelsolin are both highly expressed but differentially localized in kidney and intestine. Lueck, A., Brown, D., Kwiatkowski, D.J. J. Cell. Sci. (1998) [Pubmed]
  6. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Mejillano, M.R., Kojima, S., Applewhite, D.A., Gertler, F.B., Svitkina, T.M., Borisy, G.G. Cell (2004) [Pubmed]
  7. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Witke, W., Sharpe, A.H., Hartwig, J.H., Azuma, T., Stossel, T.P., Kwiatkowski, D.J. Cell (1995) [Pubmed]
  8. Gelsolin functions as a metastasis suppressor in B16-BL6 mouse melanoma cells and requirement of the carboxyl-terminus for its effect. Fujita, H., Okada, F., Hamada , J., Hosokawa, M., Moriuchi, T., Koya, R.C., Kuzumaki, N. Int. J. Cancer (2001) [Pubmed]
  9. The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. Furukawa, K., Fu, W., Li, Y., Witke, W., Kwiatkowski, D.J., Mattson, M.P. J. Neurosci. (1997) [Pubmed]
  10. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. Chellaiah, M.A., Biswas, R.S., Yuen, D., Alvarez, U.M., Hruska, K.A. J. Biol. Chem. (2001) [Pubmed]
  11. Advances in amyloidosis. Cohen, A.S., Jones, L.A. Current opinion in rheumatology. (1993) [Pubmed]
  12. The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesis. Crowley, M.R., Head, K.L., Kwiatkowski, D.J., Asch, H.L., Asch, B.B. Dev. Biol. (2000) [Pubmed]
  13. Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation. Dong, J.H., Ying, G.X., Liu, X., Wang, W.Y., Wang, Y., Ni, Z.M., Zhou, C.F. Hippocampus. (2006) [Pubmed]
  14. Calcium regulation of gelsolin and adseverin: a natural test of the helix latch hypothesis. Lueck, A., Yin, H.L., Kwiatkowski, D.J., Allen, P.G. Biochemistry (2000) [Pubmed]
  15. gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Yu, F.X., Johnston, P.A., Südhof, T.C., Yin, H.L. Science (1990) [Pubmed]
  16. Neuroprotective effects of gelsolin during murine stroke. Endres, M., Fink, K., Zhu, J., Stagliano, N.E., Bondada, V., Geddes, J.W., Azuma, T., Mattson, M.P., Kwiatkowski, D.J., Moskowitz, M.A. J. Clin. Invest. (1999) [Pubmed]
  17. Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid. Meerschaert, K., De Corte, V., De Ville, Y., Vandekerckhove, J., Gettemans, J. EMBO J. (1998) [Pubmed]
  18. Separate functions of gelsolin mediate sequential steps of collagen phagocytosis. Arora, P.D., Chan, M.W., Anderson, R.A., Janmey, P.A., McCulloch, C.A. Mol. Biol. Cell (2005) [Pubmed]
  19. Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression. Azuma, T., Koths, K., Flanagan, L., Kwiatkowski, D. J. Biol. Chem. (2000) [Pubmed]
  20. Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption. Biswas, R.S., Baker, D., Hruska, K.A., Chellaiah, M.A. BMC Cell Biol. (2004) [Pubmed]
  21. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Kothakota, S., Azuma, T., Reinhard, C., Klippel, A., Tang, J., Chu, K., McGarry, T.J., Kirschner, M.W., Koths, K., Kwiatkowski, D.J., Williams, L.T. Science (1997) [Pubmed]
  22. Effects of hsp70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia. Lee, S.H., Kwon, H.M., Kim, Y.J., Lee, K.M., Kim, M., Yoon, B.W. Stroke (2004) [Pubmed]
  23. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Calon, F., Lim, G.P., Morihara, T., Yang, F., Ubeda, O., Salem, N., Frautschy, S.A., Cole, G.M. Eur. J. Neurosci. (2005) [Pubmed]
  24. Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. Onda, H., Lueck, A., Marks, P.W., Warren, H.B., Kwiatkowski, D.J. J. Clin. Invest. (1999) [Pubmed]
  25. Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines. Geng, Y.J., Azuma, T., Tang, J.X., Hartwig, J.H., Muszynski, M., Wu, Q., Libby, P., Kwiatkowski, D.J. Eur. J. Cell Biol. (1998) [Pubmed]
  26. Mbh 1: a novel gelsolin/severin-related protein which binds actin in vitro and exhibits nuclear localization in vivo. Prendergast, G.C., Ziff, E.B. EMBO J. (1991) [Pubmed]
  27. Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Pilz, A., Moseley, H., Peters, J., Abbott, C. Genomics (1992) [Pubmed]
  28. Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo. Leifeld, L., Fink, K., Debska, G., Fielenbach, M., Schmitz, V., Sauerbruch, T., Spengler, U. Am. J. Pathol. (2006) [Pubmed]
  29. DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1. Kannan, K., Kaminski, N., Rechavi, G., Jakob-Hirsch, J., Amariglio, N., Givol, D. Oncogene (2001) [Pubmed]
  30. Differential developmentally regulated expression of gelsolin family members in the mouse. Arai, M., Kwiatkowski, D.J. Dev. Dyn. (1999) [Pubmed]
  31. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. Dabiri, G.A., Young, C.L., Rosenbloom, J., Southwick, F.S. J. Biol. Chem. (1992) [Pubmed]
  32. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. Barron-Casella, E.A., Torres, M.A., Scherer, S.W., Heng, H.H., Tsui, L.C., Casella, J.F. J. Biol. Chem. (1995) [Pubmed]
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