Gene Review:
FASLG - Fas ligand (TNF superfamily, member 6)
Homo sapiens
Synonyms:
ALPS1B, APT1LG1, APTL, Apoptosis antigen ligand, CD178, ...
- Regulation of FAS ligand expression by chemokine ligand 2 in human endometrial cells. Selam, B., Kayisli, U.A., Akbas, G.E., Basar, M., Arici, A. Biol. Reprod. (2006)
- Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Pitti, R.M., Marsters, S.A., Lawrence, D.A., Roy, M., Kischkel, F.C., Dowd, P., Huang, A., Donahue, C.J., Sherwood, S.W., Baldwin, D.T., Godowski, P.J., Wood, W.I., Gurney, A.L., Hillan, K.J., Cohen, R.L., Goddard, A.D., Botstein, D., Ashkenazi, A. Nature (1998)
- CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Tateyama, M., Oyaizu, N., McCloskey, T.W., Than, S., Pahwa, S. Blood (2000)
- HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Muthumani, K., Choo, A.Y., Hwang, D.S., Premkumar, A., Dayes, N.S., Harris, C., Green, D.R., Wadsworth, S.A., Siekierka, J.J., Weiner, D.B. Blood (2005)
- CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. Bremer, E., ten Cate, B., Samplonius, D.F., de Leij, L.F., Helfrich, W. Blood (2006)
- Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer. Zhang, B., Sun, T., Xue, L., Han, X., Zhang, B., Lu, N., Shi, Y., Tan, W., Zhou, Y., Zhao, D., Zhang, X., Guo, Y., Lin, D. Carcinogenesis (2007)
- Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depression. Parissis, J.T., Adamopoulos, S., Rigas, A., Kostakis, G., Karatzas, D., Venetsanou, K., Kremastinos, D.T. Am. J. Cardiol. (2004)
- Induction of tumour cell apoptosis by matrix metalloproteinase inhibitors: new tricks from a (not so) old drug. Mitsiades, N., Poulaki, V., Mitsiades, C.S., Anderson, K.C. Expert opinion on investigational drugs. (2001)
- Metalloproteinase shedding of Fas ligand regulates beta-amyloid neurotoxicity. Ethell, D.W., Kinloch, R., Green, D.R. Curr. Biol. (2002)
- On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model. Greil, R., Egle, A., Villunger, A. Leuk. Lymphoma (1998)
- Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex. Sabri, F., De Milito, A., Pirskanen, R., Elovaara, I., Hagberg, L., Cinque, P., Price, R., Chiodi, F. J. Neuroimmunol. (2001)
- Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. Lenardo, M., Chan, K.M., Hornung, F., McFarland, H., Siegel, R., Wang, J., Zheng, L. Annu. Rev. Immunol. (1999)
- Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Brunet, A., Bonni, A., Zigmond, M.J., Lin, M.Z., Juo, P., Hu, L.S., Anderson, M.J., Arden, K.C., Blenis, J., Greenberg, M.E. Cell (1999)
- Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Wang, J., Zheng, L., Lobito, A., Chan, F.K., Dale, J., Sneller, M., Yao, X., Puck, J.M., Straus, S.E., Lenardo, M.J. Cell (1999)
- Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Suda, T., Takahashi, T., Golstein, P., Nagata, S. Cell (1993)
- NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells. Hermisson, M., Weller, M. Cell Death Differ. (2003)
- Induction of Fas expression and augmentation of Fas/Fas ligand-mediated apoptosis by the synthetic retinoid CD437 in human lung cancer cells. Sun, S.Y., Yue, P., Hong, W.K., Lotan, R. Cancer Res. (2000)
- Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. Mansouri, A., Ridgway, L.D., Korapati, A.L., Zhang, Q., Tian, L., Wang, Y., Siddik, Z.H., Mills, G.B., Claret, F.X. J. Biol. Chem. (2003)
- FAS/FAS ligand ratio: a marker of oxaliplatin-based intrinsic and acquired resistance in advanced colorectal cancer. Nadal, C., Maurel, J., Gallego, R., Castells, A., Longarón, R., Marmol, M., Sanz, S., Molina, R., Martin-Richard, M., Gascón, P. Clin. Cancer Res. (2005)
- DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., Green, D.R. Mol. Cell (1998)
- Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death. Dutton, A., O'Neil, J.D., Milner, A.E., Reynolds, G.M., Starczynski, J., Crocker, J., Young, L.S., Murray, P.G. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. Krum, S.A., Miranda-Carboni, G.A., Hauschka, P.V., Carroll, J.S., Lane, T.F., Freedman, L.P., Brown, M. EMBO. J. (2008)
- Identification of amino acid residues important for ligand binding to Fas. Starling, G.C., Bajorath, J., Emswiler, J., Ledbetter, J.A., Aruffo, A., Kiener, P.A. J. Exp. Med. (1997)
- Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. Aragane, Y., Kulms, D., Metze, D., Wilkes, G., Pöppelmann, B., Luger, T.A., Schwarz, T. J. Cell Biol. (1998)
- Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. Herr, I., Wilhelm, D., Böhler, T., Angel, P., Debatin, K.M. EMBO J. (1997)
- Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment. Chan, H., Bartos, D.P., Owen-Schaub, L.B. Mol. Cell. Biol. (1999)
- Casper is a FADD- and caspase-related inducer of apoptosis. Shu, H.B., Halpin, D.R., Goeddel, D.V. Immunity (1997)
- Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mittelstadt, P.R., Ashwell, J.D. Mol. Cell. Biol. (1998)
- c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Kolbus, A., Herr, I., Schreiber, M., Debatin, K.M., Wagner, E.F., Angel, P. Mol. Cell. Biol. (2000)
- Fluorescence resonance energy transfer analysis of proapoptotic CD95-EGF receptor interactions in Huh7 cells. Eberle, A., Reinehr, R., Becker, S., Häussinger, D. Hepatology (2005)
- Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Aoki, K., Kurooka, M., Chen, J.J., Petryniak, J., Nabel, E.G., Nabel, G.J. Nat. Immunol. (2001)
- Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand. Matsuno, H., Yudoh, K., Watanabe, Y., Nakazawa, F., Aono, H., Kimura, T. J. Rheumatol. (2001)
- Irradiation-induced up-regulation of Fas in esophageal squamous cell carcinoma is not accompanied by Fas ligand-mediated apoptosis. Rigberg, D.A., Centeno, J., Kim, F.S., Ke, B., Swenson, K., Maggard, M., McFadden, D.W. Journal of surgical oncology. (1999)
- Serum concentration of soluble decoy receptor 3 in glioma patients before and after surgery. Hwang, S.L., Lin, C.L., Cheng, C.Y., Lin, F.A., Lieu, A.S., Howng, S.L., Lee, K.S. The Kaohsiung journal of medical sciences. (2004)
- alpha-fetoprotein causes apoptosis in tumor cells via a pathway independent of CD95, TNFR1 and TNFR2 through activation of caspase-3-like proteases. Dudich, E., Semenkova, L., Dudich, I., Gorbatova, E., Tochtamisheva, N., Tatulov, E., Nikolaeva, M., Sukhikh, G. Eur. J. Biochem. (1999)
- Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity. Mitsiades, N., Yu, W.H., Poulaki, V., Tsokos, M., Stamenkovic, I. Cancer Res. (2001)
- Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. Irmler, M., Steiner, V., Ruegg, C., Wajant, H., Tschopp, J. FEBS Lett. (2000)
- Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells. Dicker, F., Kater, A.P., Fukuda, T., Kipps, T.J. Blood (2005)
- Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter. Faris, M., Latinis, K.M., Kempiak, S.J., Koretzky, G.A., Nel, A. Mol. Cell. Biol. (1998)
- Hepatocytes as cytotoxic effector cells can induce cell death by CD95 ligand-mediated pathway. Guy, C.S., Wang, J., Michalak, T.I. Hepatology (2006)
- Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and -independent apoptotic pathways. Jain, J.K., Li, A., Nucatola, D.L., Minoo, P., Felix, J.C. Biol. Reprod. (2005)
- Effect of a vascular endothelial growth factor (VEGF) inhibitory treatment on the folliculogenesis and ovarian apoptosis in gonadotropin-treated prepubertal rats. Abramovich, D., Parborell, F., Tesone, M. Biol. Reprod. (2006)