Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Renese 4-chloro-9-methyl-10,10- dioxo-8-(2,2,2...

Synonyms: Drenusil, Nephril, Politiazida, polythiazide, Polythiazidum, ...

Chachati, A. et al., Nilsson, G., Weber, M.A. et al., Helgeland, A., Drayer, J.I. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of polythiazide

This report describes a double-blind, parallel, comparative study of trimazosin (+/- polythiazide) and propranolol (+/- polythiazide) in 130 patients with essential hypertension [1].
Symptomatic diabetes mellitus cured by potassium and withdrawal of polythiazide in a hypokalemic hypertensive woman [2].
A case of symptomatic diabetes mellitus in a 65-year-old woman with 14 years of polythiazide treatment and hypokalemia is described [2].

High impact information on polythiazide

If diastolic blood pressure was not adequately controlled (less than 85 mm Hg) after four weeks of monotherapy, 1 mg of polythiazide was added to the daily regimen [3].
We evaluated the effects of treatment with the vasodilator trimazosin, alone and in combination with the diuretic polythiazide, on cardiac muscle mass in hypertensive subjects [4].
Kinetics of polythiazide [5].
Determination of polythiazide and prazosin in human plasma by high-performance liquid chromatography [6].
In the light of accumulating evidence implicating the diluting segment as the site of final regulation of sodium excretion by the nephron, we produced in this experiment distal blockade in anti-glomerular basement membrane (GBM) glomerulonephritic (GN) rats by the administration of furosemide and polythiazide [7].

Chemical compound and disease context of polythiazide

Antihypertensive effect of prazosin alone and its combination with polythiazide in patients with essential hypertension [8].

Associations of polythiazide with other chemical compounds

In seven patients whose blood pressures were not controlled by trimazosin alone, the addition of polythiazide led to decreased blood pressure and in five control of pressure was achieved [9].

Analytical, diagnostic and therapeutic context of polythiazide

A method is presented for the quantitative analysis of polythiazide tablets by high-pressure liquid chromatography [10].
A double-blind study of trimazosin and methyldopa in hypertensive patients receiving polythiazide [11].

References

Double-blind comparison of trimazosin and propranolol in essential hypertension. Helgeland, A. Am. Heart J. (1983) [Pubmed]
Symptomatic diabetes mellitus cured by potassium and withdrawal of polythiazide in a hypokalemic hypertensive woman. Nilsson, G. Acta medica Scandinavica. (1980) [Pubmed]
Prazosin versus captopril as initial therapy. Effect on hypertension and lipid levels. Okun, R., Kraut, J. Am. J. Med. (1987) [Pubmed]
Cardiac muscle mass during vasodilation therapy of hypertension. Drayer, J.I., Gardin, J.M., Weber, M.A., Aronow, W.S. Clin. Pharmacol. Ther. (1983) [Pubmed]
Kinetics of polythiazide. Hobbs, D.C., Twomey, T.M. Clin. Pharmacol. Ther. (1978) [Pubmed]
Determination of polythiazide and prazosin in human plasma by high-performance liquid chromatography. Dokladalova, J., Coco, S.J., Lemke, P.R., Quercia, G.T., Korst, J.J. J. Chromatogr. (1981) [Pubmed]
Distal blockade in experimental glomerulonephritis: the role of the diluting segment in sodium retention. Chachati, A., Godon, J.P. Arch. Int. Physiol. Biochim. (1985) [Pubmed]
Antihypertensive effect of prazosin alone and its combination with polythiazide in patients with essential hypertension. Guevara, J., Collet-Velasco, H., Velasco, M. Current therapeutic research, clinical and experimental. (1976) [Pubmed]
A vasodilator that avoids renin stimulation and fluid retention: antihypertensive treatment with trimazosin. Weber, M.A., Brewer, D.D., Drayer, J.I., Aronow, W.S., Lipson, J.L., Ricci, B.A. Clin. Pharmacol. Ther. (1982) [Pubmed]
Determination of polythiazide in pharmaceutical dosage forms by high-pressure liquid chromatography. Moskalyk, R.E., Locock, R.A., Chatten, L.G., Veltman, A.M., Bielech, M.F. Journal of pharmaceutical sciences. (1975) [Pubmed]
A double-blind study of trimazosin and methyldopa in hypertensive patients receiving polythiazide. Moyer, R.R. Am. Heart J. (1983) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.