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Chemical Compound Review

FIACITABINE     4-amino-1-[(2R,3S,4R,5R)-3- fluoro-4...

Synonyms: Fiacitabina, FIAC, FOAC, Fiacitabinum, FI-ara-C, ...
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Disease relevance of FIACITABINE


Analytical, diagnostic and therapeutic context of FIACITABINE

  • However, fluoroiodoaracytidine and dihydroxypropoxymethylguanine were found to affect the SCE rate at a concentration (greater than or equal to 4.5 micrograms/ml) that is readily achievable in blood following intravenous injection [3].


  1. Phase I evaluation of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in immunosuppressed patients with herpesvirus infection. Young, C.W., Schneider, R., Leyland-Jones, B., Armstrong, D., Tan, C.T., Lopez, C., Watanabe, K.A., Fox, J.J., Philips, F.S. Cancer Res. (1983) [Pubmed]
  2. Metabolic competition studies of 2'-fluoro-5-iodo-1-beta-d-arabinofuranosylcytosine in vero cells and herpes simplex type 1-infected vero cells. Chou, T.C., Lopez, C., Colacino, J.M., Feinberg, A., Watanabe, K.A., Fox, J.J., Philips, F.S. Mol. Pharmacol. (1984) [Pubmed]
  3. Mutagenic potential of anti-herpes agents. De Clercq, E., Cassiman, J.J. Life Sci. (1986) [Pubmed]
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