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Chemical Compound Review

SILYMARIN     3,5,7-trihydroxy-2-[9-(4- hydroxy-3-methoxy...

Synonyms: Silybin, silibinin, Silybin B, AGN-PC-00JFVG, CHEMBL592675, ...
 
 
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Disease relevance of SILYMARIN

 

Associations of SILYMARIN with other chemical compounds

  • Repeated administration of silipide was safe and achieved levels of silibinin of 0.3 to 4 micromol/L in the plasma, 0.3 to 2.5 nmol/g tissue in the liver, and 20 to 141 nmol/g tissue in colorectal tissue [2].
  • Silibinin feeding showed a dose-dependent decrease in azoxymethane-induced colon tumorigenesis with stronger efficacy in pretreatment versus posttreatment regimen [3].
  • Quantification of micro-CT data in real-time showed that silibinin significantly decreases urethane-induced tumor number and size in WT mice, consistent with measurements made ex vivo at study termination [4].
 

Gene context of SILYMARIN

  • Analyses of normal skin, uninvolved skin from tumor-bearing mice, and skin tumors showed a statistically significant decrease (P < 0.05-0.001) in inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) levels by silibinin [5].
  • Silibinin suppressed AP-1-binding activity and c-Jun levels and its phosphorylation without changes of c-Fos and Ets-1 levels [6].

References

  1. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Singh, R.P., Tyagi, A., Sharma, G., Mohan, S., Agarwal, R. Clin. Cancer Res. (2008) [Pubmed]
  2. Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. Hoh, C., Boocock, D., Marczylo, T., Singh, R., Berry, D.P., Dennison, A.R., Hemingway, D., Miller, A., West, K., Euden, S., Garcea, G., Farmer, P.B., Steward, W.P., Gescher, A.J. Clin. Cancer Res. (2006) [Pubmed]
  3. Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. Ravichandran, K., Velmurugan, B., Gu, M., Singh, R.P., Agarwal, R. Clin. Cancer Res. (2010) [Pubmed]
  4. Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies. Ramasamy, K., Dwyer-Nield, L.D., Serkova, N.J., Hasebroock, K.M., Tyagi, A., Raina, K., Singh, R.P., Malkinson, A.M., Agarwal, R. Clin. Cancer Res. (2011) [Pubmed]
  5. Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Gu, M., Singh, R.P., Dhanalakshmi, S., Agarwal, C., Agarwal, R. Cancer Res. (2007) [Pubmed]
  6. Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. Hsieh, Y.S., Chu, S.C., Yang, S.F., Chen, P.N., Liu, Y.C., Lu, K.H. Carcinogenesis (2007) [Pubmed]
 
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