Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Geranilyc acid (2E)-3,7-dimethylocta-2,6- dienoic acid

Synonyms: Geranoic acid, GERANIC ACID, Nerolic acid, CHEMBL170190, Neric acid, ...

Yamaguchi, T. et al.

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Disease relevance of Decaprenoic acid

The combination of BLM or FUra with decaprenoic acid, when administered by iv injection to mice with fibrosarcoma Meth A (solid tumor system), did not produce synergism [1].
The antitumor effects of combinations of synthetic isoprenoids-decaprenylamine.HCl, N-(p-methylbenzyl)decaprenylamine.HCl [N-(PMB)-decaprenylamine.HCl], and decaprenoic acid-with anticancer agents were studied in male ICR mice with ascites sarcoma 180 (S180) and in male BALB/c mice with fibrosarcoma Meth A [1].

References

Potentiation of anticancer agents by new synthetic isoprenoids. II. Inhibition of the growth of transplantable murine tumors. Yamaguchi, T., Ikezaki, K., Kishiye, T., Tahara, Y., Koyama, H., Takahasi, T., Fukawa, H., Komiyama, S., Akiyama, S., Kuwano, M. J. Natl. Cancer Inst. (1984) [Pubmed]

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