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Chemical Compound Review

CHEMBL171326     (2E,6E,10E)-3,7,11,15- tetramethylhexadeca...

Synonyms: AC1NQN4U, 83807-40-3, NCGC00163653-01, Geranylgeranic acid, Geranylgeranoic acid
 
 
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Disease relevance of Geranylgeranic acid

  • A synthetic geranylgeranoic acid (GGA) induced apoptotic cell death in a human hepatoma cell line, HuH-7, but not in mouse primary cultured hepatocytes [1].
  • The observation of a negative ion at m/z 305 on ESI and a molecular ion at m/z 306 (C(20)H(34)O(2)) with fragments similar to GGA on EI implied that Z2 was dihydroGGA, which has been detected in the urine and serum of patients with Refsum disease [2].
 

High impact information on Geranylgeranic acid

 

Anatomical context of Geranylgeranic acid

References

  1. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis. Shidoji, Y., Nakamura, N., Moriwaki, H., Muto, Y. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  2. Formation of (R)-2,3-dihydrogeranylgeranoic acid from geranylgeraniol in rat thymocytes. Kodaira, Y., Usui, K., Kon, I., Sagami, H. J. Biochem. (2002) [Pubmed]
  3. Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formation. Wang, X., Wu, J., Shidoji, Y., Muto, Y., Ohishi, N., Yagi, K., Ikegami, S., Shinki, T., Udagawa, N., Suda, T., Ishimi, Y. J. Bone Miner. Res. (2002) [Pubmed]
  4. Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbs. Shidoji, Y., Ogawa, H. J. Lipid Res. (2004) [Pubmed]
  5. Apoptosis in human hepatoma cell line induced by 4,5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-alpha. Nakamura, N., Shidoji, Y., Moriwaki, H., Muto, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
 
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