Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

CHEMBL171326 (2E,6E,10E)-3,7,11,15- tetramethylhexadeca...

Synonyms: AC1NQN4U, 83807-40-3, NCGC00163653-01, Geranylgeranic acid, Geranylgeranoic acid

Wang, X. et al., Shidoji, Y. et al., Kodaira, Y. et al., Shidoji, Y. et al., Nakamura, N. et al.

Shidoji, Ogawa, Kodaira, Usui, Kon, Sagami,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Geranylgeranic acid

A synthetic geranylgeranoic acid (GGA) induced apoptotic cell death in a human hepatoma cell line, HuH-7, but not in mouse primary cultured hepatocytes [1].
The observation of a negative ion at m/z 305 on ESI and a molecular ion at m/z 306 (C(20)H(34)O(2)) with fragments similar to GGA on EI implied that Z2 was dihydroGGA, which has been detected in the urine and serum of patients with Refsum disease [2].

High impact information on Geranylgeranic acid

In this study, we examined the osteogenic effects of geranylgeranoic acid (GGA), a chemically synthesized acyclic retinoid, in bone in vitro and in vivo [3].
Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formation [3].
Geranylgeranoic acid (GGA; all-trans 3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid) has been shown to induce apoptosis in a human hepatoma-derived cell line, HuH-7 [4].
Apoptosis in human hepatoma cell line induced by 4,5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-alpha [5].

Anatomical context of Geranylgeranic acid

Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis [1].

References

Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis. Shidoji, Y., Nakamura, N., Moriwaki, H., Muto, Y. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
Formation of (R)-2,3-dihydrogeranylgeranoic acid from geranylgeraniol in rat thymocytes. Kodaira, Y., Usui, K., Kon, I., Sagami, H. J. Biochem. (2002) [Pubmed]
Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formation. Wang, X., Wu, J., Shidoji, Y., Muto, Y., Ohishi, N., Yagi, K., Ikegami, S., Shinki, T., Udagawa, N., Suda, T., Ishimi, Y. J. Bone Miner. Res. (2002) [Pubmed]
Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbs. Shidoji, Y., Ogawa, H. J. Lipid Res. (2004) [Pubmed]
Apoptosis in human hepatoma cell line induced by 4,5-didehydro geranylgeranoic acid (acyclic retinoid) via down-regulation of transforming growth factor-alpha. Nakamura, N., Shidoji, Y., Moriwaki, H., Muto, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.