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Gene Review

Bmp7  -  bone morphogenetic protein 7

Mus musculus

Synonyms: BMP-7, Bmp-7, Bone morphogenetic protein 7, OP-1, OP1, ...
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Disease relevance of Bmp7


Psychiatry related information on Bmp7


High impact information on Bmp7

  • Here we show that Smurf1, a HECT domain ubiquitin ligase, has a specific physiological role in suppressing the osteogenic activity of osteoblasts [7].
  • This phenotype results from defective proliferation of osteoprogenitors at the osteogenic front during calvarial morphogenesis, and closely resembles that associated with human MSX2 haploinsufficiency in parietal foramina (PFM) [8].
  • Osf2/Cbfa1 expression is initiated in the mesenchymal condensations of the developing skeleton, is strictly restricted to cells of the osteoblast lineage thereafter, and is regulated by BMP7 and vitamin D3 [9].
  • Smad1-dependent transcription and phosphorylated Smad1 (P-Smad1) levels are increased, as KCP binds to BMP7 and enhances binding to the type I receptor [10].
  • The origins of the multinucleated osteoclast have been controversial, with osteogenic precursors and haematopoietic stem cells as candidates [11].

Chemical compound and disease context of Bmp7


Biological context of Bmp7

  • In the foot plates of the mutant homozygotes, both Bmp2 and Bmp7 expression and apoptotic interdigital cell death are reduced [17].
  • On the other hand, mice double heterozygous for null Fbn2 and Bmp7 alleles display the combined digit phenotype of both nullizygotes [18].
  • Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation [19].
  • Here, we report that removal of one allele of Bmp7 exacerbates the phenotype of Bmp8a null mutants in spermatogenesis and epididymis of the adult [20].
  • Targeted inactivation of the Bmp7 gene in mouse leads to eye defects with late onset and variable penetrance (A. T. Dudley et al., 1995, Genes Dev. 9, 2795-2807; G. Luo et al., 1995, Genes Dev. 9, 2808-2820) [21].

Anatomical context of Bmp7


Associations of Bmp7 with chemical compounds


Regulatory relationships of Bmp7


Other interactions of Bmp7


Analytical, diagnostic and therapeutic context of Bmp7


  1. Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy. Wang, S.N., Lapage, J., Hirschberg, R. J. Am. Soc. Nephrol. (2001) [Pubmed]
  2. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation. Ishidou, Y., Kitajima, I., Obama, H., Maruyama, I., Murata, F., Imamura, T., Yamada, N., ten Dijke, P., Miyazono, K., Sakou, T. J. Bone Miner. Res. (1995) [Pubmed]
  3. Inhibition of terminal chondrocyte differentiation by bone morphogenetic protein 7 (OP-1) in vitro depends on the periarticular region but is independent of parathyroid hormone-related peptide. Haaijman, A., Karperien, M., Lanske, B., Hendriks, J., Löwik, C.W., Bronckers, A.L., Burger, E.H. Bone (1999) [Pubmed]
  4. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Lin, J., Patel, S.R., Wang, M., Dressler, G.R. Mol. Cell. Biol. (2006) [Pubmed]
  5. Modulator of bone morphogenetic protein activity in the progression of kidney diseases. Yanagita, M. Kidney Int. (2006) [Pubmed]
  6. Partially purified reindeer (Rangifer tarandus) bone morphogenetic protein has a high bone-forming activity compared with some other artiodactyls. Jortikka, L., Marttinen, A., Lindholm, T.S. Clin. Orthop. Relat. Res. (1993) [Pubmed]
  7. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Yamashita, M., Ying, S.X., Zhang, G.M., Li, C., Cheng, S.Y., Deng, C.X., Zhang, Y.E. Cell (2005) [Pubmed]
  8. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., Peters, H., Tang, Z., Maxson, R., Maas, R. Nat. Genet. (2000) [Pubmed]
  9. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., Karsenty, G. Cell (1997) [Pubmed]
  10. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Lin, J., Patel, S.R., Cheng, X., Cho, E.A., Levitan, I., Ullenbruch, M., Phan, S.H., Park, J.M., Dressler, G.R. Nat. Med. (2005) [Pubmed]
  11. Osteoclasts derived from haematopoietic stem cells. Ash, P., Loutit, J.F., Townsend, K.M. Nature (1980) [Pubmed]
  12. Noggin gene delivery inhibits cementoblast-induced mineralization. Jin, Q.M., Zhao, M., Economides, A.N., Somerman, M.J., Giannobile, W.V. Connect. Tissue Res. (2004) [Pubmed]
  13. Differential uptake of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea and doxorubicin by Lewis lung carcinoma and Ridgway osteogenic sarcoma. Schmid, F.A., Otter, G.M., Perri, G.C., Hutchison, D.J., Philips, F.S. Cancer Res. (1983) [Pubmed]
  14. Cyclophosphamide-adriamycin combination chemotherapy of transplantable murine tumors. Corbett, T.H., Griswold, D.P., Mayo, J.G., Laster, W.R., Schabel, F.M. Cancer Res. (1975) [Pubmed]
  15. Kinase and deaminase activity in a variety of subcutaneous mouse tumors. Furner, R.L., Mellett, L.B. Cancer Res. (1975) [Pubmed]
  16. Potentiation of methotrexate toxicity by dipyridamole. Nelson, J.A., Drake, S. Cancer Res. (1984) [Pubmed]
  17. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Jiang, R., Lan, Y., Chapman, H.D., Shawber, C., Norton, C.R., Serreze, D.V., Weinmaster, G., Gridley, T. Genes Dev. (1998) [Pubmed]
  18. Regulation of limb patterning by extracellular microfibrils. Arteaga-Solis, E., Gayraud, B., Lee, S.Y., Shum, L., Sakai, L., Ramirez, F. J. Cell Biol. (2001) [Pubmed]
  19. Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation. Dean, C., Ito, M., Makarenkova, H.P., Faber, S.C., Lang, R.A. Development (2004) [Pubmed]
  20. Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis. Zhao, G.Q., Chen, Y.X., Liu, X.M., Xu, Z., Qi, X. Dev. Biol. (2001) [Pubmed]
  21. BMP7 acts in murine lens placode development. Wawersik, S., Purcell, P., Rauchman, M., Dudley, A.T., Robertson, E.J., Maas, R. Dev. Biol. (1999) [Pubmed]
  22. Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dupé, V., Ghyselinck, N.B., Thomazy, V., Nagy, L., Davies, P.J., Chambon, P., Mark, M. Dev. Biol. (1999) [Pubmed]
  23. p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1. Hu, M.C., Wasserman, D., Hartwig, S., Rosenblum, N.D. J. Biol. Chem. (2004) [Pubmed]
  24. Androgen-dependent gene expression of bone morphogenetic protein 7 in mouse prostate. Thomas, R., Anderson, W.A., Raman, V., Reddi, A.H. Prostate (1998) [Pubmed]
  25. Osteogenic and chondrogenic differentiation of embryonic stem cells in response to specific growth factors. Kawaguchi, J., Mee, P.J., Smith, A.G. Bone (2005) [Pubmed]
  26. MyoD enhances BMP7-induced osteogenic differentiation of myogenic cell cultures. Komaki, M., Asakura, A., Rudnicki, M.A., Sodek, J., Cheifetz, S. J. Cell. Sci. (2004) [Pubmed]
  27. BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Grishina, I.B., Kim, S.Y., Ferrara, C., Makarenkova, H.P., Walden, P.D. Dev. Biol. (2005) [Pubmed]
  28. BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis. Shea, C.M., Edgar, C.M., Einhorn, T.A., Gerstenfeld, L.C. J. Cell. Biochem. (2003) [Pubmed]
  29. Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Leung-Hagesteijn, C., Hu, M.C., Mahendra, A.S., Hartwig, S., Klamut, H.J., Rosenblum, N.D., Hannigan, G.E. Mol. Cell. Biol. (2005) [Pubmed]
  30. BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Ahn, K., Mishina, Y., Hanks, M.C., Behringer, R.R., Crenshaw, E.B. Development (2001) [Pubmed]
  31. Fgf receptor signaling plays a role in lens induction. Faber, S.C., Dimanlig, P., Makarenkova, H.P., Shirke, S., Ko, K., Lang, R.A. Development (2001) [Pubmed]
  32. Apoptosis in murine calvarial bone and suture development. Rice, D.P., Kim, H.J., Thesleff, I. Eur. J. Oral Sci. (1999) [Pubmed]
  33. Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments. Haaijman, A., Burger, E.H., Goei, S.W., Nelles, L., ten Dijke, P., Huylebroeck, D., Bronckers, A.L. Growth Factors (2000) [Pubmed]
  34. Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Wan, D.C., Shi, Y.Y., Nacamuli, R.P., Quarto, N., Lyons, K.M., Longaker, M.T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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