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Chemical Compound Review:

EMD 33512 but-2-enedioic acid; 1-(propan-2-ylamino)...

Synonyms: Bisobloc, Emvoncor, Eurtadal, Maintate, Bisomerck, ...

This record was replaced with 2405.

Lammers, J.W. et al., Wang, X.L. et al., Oosterhof, T. et al., Vriend, J.W. et al., Drenthen, W. et al., et al.

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Disease relevance of BISOPROLOL

METHODS AND RESULTS: The CONCOR national registry on congenital heart disease in The Netherlands was reviewed for women of childbearing age (> or =18 years old) with a history of aortic coarctation repair [1].
METHODS AND RESULTS: In a retrospective study, 158 adult patients with a diagnosis of tetralogy of Fallot, who had undergone a PVR after initial total correction in childhood, were identified from the CONCOR (CONgenital CORvitia) registry [2].
Using a nationwide registry (CONCOR), 37 patients with pulmonary atresia were identified, 6 of whom (aged 21 to 34 years) had biventricular repair for PAIVS [3].

High impact information on BISOPROLOL

METHODS AND RESULTS: Using a nation-wide registry (CONCOR), 79 female patients with balanced/isolated AVSD were identified [4].
The binding properties of a newly developed, highly selective beta 1-adrenoceptor antagonist radioligand, (-)[3H]bisoprolol (EMD 33512) were investigated in rabbit lung membranes containing a mixture of 80% beta 1-and 20% beta 2-adrenoceptors [5].
Bisoprolol (EMD 33512), a highly selective beta 1-adrenoceptor antagonist: in vitro and in vivo studies [6].
In a double blind, placebo-controlled study the ventilatory effects of the beta 1-selective receptor blockers bisoprolol (EMD 33512) and metoprolol and their interactions with the beta 2-adrenoceptor agonist terbutaline were investigated in 8 asthmatic patients [7].

References

Outcome of pregnancy in patients after repair of aortic coarctation. Vriend, J.W., Drenthen, W., Pieper, P.G., Roos-Hesselink, J.W., Zwinderman, A.H., van Veldhuisen, D.J., Mulder, B.J. Eur. Heart J. (2005) [Pubmed]
Long-term follow-up of homograft function after pulmonary valve replacement in patients with tetralogy of Fallot. Oosterhof, T., Meijboom, F.J., Vliegen, H.W., Hazekamp, M.G., Zwinderman, A.H., Bouma, B.J., van Dijk, A.P., Mulder, B.J. Eur. Heart J. (2006) [Pubmed]
Fertility, pregnancy, and delivery after biventricular repair for pulmonary atresia with an intact ventricular septum. Drenthen, W., Pieper, P.G., Roos-Hesselink, J.W., Zoon, N., Voors, A.A., Mulder, B.J., van Dijk, A.P., Vliegen, H.W., Sollie, K.M., Ebels, T., van Veldhuisen, D.J. Am. J. Cardiol. (2006) [Pubmed]
Cardiac complications relating to pregnancy and recurrence of disease in the offspring of women with atrioventricular septal defects. Drenthen, W., Pieper, P.G., van der Tuuk, K., Roos-Hesselink, J.W., Voors, A.A., Mostert, B., Mulder, B.J., Moons, P., Ebels, T., van Veldhuisen, D.J. Eur. Heart J. (2005) [Pubmed]
Selective labelling of beta 1-adrenoceptors in rabbit lung membranes by (-)[3H]bisoprolol. Wang, X.L., Brinkmann, M., Brodde, O.E. Eur. J. Pharmacol. (1985) [Pubmed]
Bisoprolol (EMD 33512), a highly selective beta 1-adrenoceptor antagonist: in vitro and in vivo studies. Brodde, O.E. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
Ventilatory effects of beta 1-receptor-selective blockade with bisoprolol and metoprolol in asthmatic patients. Lammers, J.W., Folgering, H.T., van Herwaarden, C.L. Eur. J. Clin. Pharmacol. (1984) [Pubmed]

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