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Chemical Compound Review:

Prunetin 5-hydroxy-3-(4- hydroxyphenyl)-7-methoxy...

Synonyms: Prunusetin, Padmakastein, Prunetin (6CI), SureCN73420, CHEMBL491174, ...

Sheikh, S. et al., Wang, S.W. et al., Hu, M. et al., Chen, J. et al.

Hu, Krausz, Chen, Ge, Li, Gelboin, Gonzalez,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Prunetin

Propionaldehyde did not reverse the loss of fluorescence obtained due to enzyme-prunetin complex formation, indicating that prunetin may not be interacting at the substrate site [1].
Isoflavonoid derivatives including prunetin (4',5-dihydroxy-7-methoxyisoflavone) were shown to be potent inhibitors of human aldehyde dehydrogenases (Keung W-M and Vallee BL, Proc Natl Acad Sci USA 90: 1247-1251, 1993) [1].
In the intestinal perfusion model, significant absorption and excretion differences were found between isoflavones and their respective glucuronides (p <0.05), with prunetin being the most rapidly absorbed and formononetin glucuronides being the most excreted in the small intestine [2].
Glucuronides were the main metabolites in intact Caco-2 cells for all isoflavones except prunetin, which was mainly sulfated [3].
Methylated isoflavones biochanin A, prunetin, and formononetin (10-100 microM) were rapidly converted by HLM and expressed CYP1A2 to more active genistein and daidzein [4].

References

Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Sheikh, S., Weiner, H. Biochem. Pharmacol. (1997) [Pubmed]
Disposition of Flavonoids via Enteric Recycling: Structural Effects and Lack of Correlations between in Vitro and in Situ Metabolic Properties. Wang, S.W., Chen, J., Jia, X., Tam, V.H., Hu, M. Drug Metab. Dispos. (2006) [Pubmed]
Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model. Chen, J., Lin, H., Hu, M. Cancer Chemother. Pharmacol. (2005) [Pubmed]
Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. Hu, M., Krausz, K., Chen, J., Ge, X., Li, J., Gelboin, H.L., Gonzalez, F.J. Drug Metab. Dispos. (2003) [Pubmed]

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