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Chemical Compound Review:

Rizaben 2-[[(E)-3-(3,4- dimethoxyphenyl)prop-2...

Synonyms: Tranpro, tranilast, Tranilastum, Rizaben (TN), SureCN29875, ...

Nishigaki, T. et al., Izawa, A. et al., Isaji, M. et al., Yasuoka, S. et al.

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Disease relevance of MK 341

Tranilast (N-(3,4-dimethoxycinnamoyl)anthranilic acid), an anti-allergic drug, has been developed and used for the treatment of anaphylactic hypersensitivity such as bronchial asthma in Japan. Recently, many cases with eosinophilic cystitis associated with administration of this drug have been reported [1].

High impact information on MK 341

Selective inhibition of collagen accumulation by N-(3,4-dimethoxycinnamoyl)anthranilic acid (N-5') in granulation tissue [2].
Inhibitory effect of N-(3,4-dimethoxycinnamoyl)anthranilic acid on release of SRS from alveolar macrophages in vitro [3].
N-(3,4-Dimethoxycinnamoyl)anthranilic acid (tranilast) inhibits cyclin-dependent kinase activity through p21(Waf1/Cip1) induction and arrests vascular smooth muscle cell proliferation in vitro [4].

References

Localization of the anti-allergic agent tranilast in the urinary bladder of rats as demonstrated by light microscopic radioautography. Nishigaki, T., Momose, Y., Nagata, T. Arzneimittel-Forschung. (1990) [Pubmed]
Selective inhibition of collagen accumulation by N-(3,4-dimethoxycinnamoyl)anthranilic acid (N-5') in granulation tissue. Isaji, M., Nakajoh, M., Naito, J. Biochem. Pharmacol. (1987) [Pubmed]
Inhibitory effect of N-(3,4-dimethoxycinnamoyl)anthranilic acid on release of SRS from alveolar macrophages in vitro. Yasuoka, S., Nii, Y., Ohgushi, F., Fujisawa, K., Kawano, T., Nakanishi, Y., Ozaki, T., Yamashita, T. Jpn. J. Pharmacol. (1986) [Pubmed]
Tranilast inhibits cardiac allograft vasculopathy in association with p21(Waf1/Cip1) expression on neointimal cells in murine cardiac transplantation model. Izawa, A., Suzuki Ji, n.u.l.l., Takahashi, W., Amano, J., Isobe, M. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]

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