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MeSH Review

Granulation Tissue

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Disease relevance of Granulation Tissue


High impact information on Granulation Tissue


Chemical compound and disease context of Granulation Tissue


Biological context of Granulation Tissue


Anatomical context of Granulation Tissue


Associations of Granulation Tissue with chemical compounds

  • The topical injection of histamine or the H(2) agonist dimaprit rescued the defective angiogenesis and granulation tissue formation in HDC(-/-) mice [8].
  • We report here that twice daily instillation of 30 mM glucose over 10 d in a rat skin chamber granulation tissue model induces approximately a 2.7-fold increase in diacylglycerol (DAG) levels (versus tissues exposed to 5 mM glucose) in association with marked increases in vascular clearance of albumin and blood flow [24].
  • Exposure of skin chamber granulation tissue vessels in nondiabetic rats to 11 or 15 mM D-glucose (but not L-glucose or 3-O-methylglucose) twice daily for 10 d induces vascular functional changes (increased albumin permeation and blood flow) identical to those in animals with mild or severe streptozotocin diabetes, respectively [25].
  • When the NH2-terminal sequence of alpha-SMA Ac-EEED is delivered to cultured myofibroblast in the form of a fusion peptide (FP) with a cell penetrating sequence, it inhibits their contractile activity; moreover, upon topical administration in vivo it inhibits the contraction of rat wound granulation tissue [26].
  • Extravascular transport of fluorescein isothiocyanate-conjugated bovine serum albumin and a graded series of fluorescein isothiocyanate-dextrans from Mr 19,400 to 71,800 were studied in both normal tissue (granulation) and tumor (VX2 carcinoma) grown in a rabbit ear chamber [27].

Gene context of Granulation Tissue


Analytical, diagnostic and therapeutic context of Granulation Tissue


  1. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Scanlan, M.J., Raj, B.K., Calvo, B., Garin-Chesa, P., Sanz-Moncasi, M.P., Healey, J.H., Old, L.J., Rettig, W.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Decorin is produced by capillary endothelial cells in inflammation-associated angiogenesis. Nelimarkka, L., Salminen, H., Kuopio, T., Nikkari, S., Ekfors, T., Laine, J., Pelliniemi, L., Järveläinen, H. Am. J. Pathol. (2001) [Pubmed]
  3. Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation. Xing, Z., Tremblay, G.M., Sime, P.J., Gauldie, J. Am. J. Pathol. (1997) [Pubmed]
  4. CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma. Pammer, J., Plettenberg, A., Weninger, W., Diller, B., Mildner, M., Uthman, A., Issing, W., Stürzl, M., Tschachler, E. Am. J. Pathol. (1996) [Pubmed]
  5. Pleural mesothelioma of connective tissue type, localized fibrous tumour of the pleura, and reactive submesothelial hyperplasia. An immunohistochemical comparison. Al-Izzi, M., Thurlow, N.P., Corrin, B. J. Pathol. (1989) [Pubmed]
  6. A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. Blankesteijn, W.M., Essers-Janssen, Y.P., Verluyten, M.J., Daemen, M.J., Smits, J.F. Nat. Med. (1997) [Pubmed]
  7. Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Rappolee, D.A., Mark, D., Banda, M.J., Werb, Z. Science (1988) [Pubmed]
  8. Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase-deficient mice but not in mast cell-deficient mice. Ghosh, A.K., Hirasawa, N., Ohtsu, H., Watanabe, T., Ohuchi, K. J. Exp. Med. (2002) [Pubmed]
  9. Dexamethasone abrogates the fibrogenic effect of transforming growth factor-beta in rat granuloma and granulation tissue fibroblasts. Meisler, N., Keefer, K.A., Ehrlich, H.P., Yager, D.R., Myers-Parrelli, J., Cutroneo, K.R. J. Invest. Dermatol. (1997) [Pubmed]
  10. Inhibition of granulation tissue growth by histamine. Saeki, K., Yokoyama, J., Wake, K. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  11. Intimal neovascularization in human coronary atherosclerosis: its origin and pathophysiological significance. Kumamoto, M., Nakashima, Y., Sueishi, K. Hum. Pathol. (1995) [Pubmed]
  12. Acne of the fulminans type following testosterone therapy in three excessively tall boys. Traupe, H., von Mühlendahl, K.E., Brämswig, J., Happle, R. Archives of dermatology. (1988) [Pubmed]
  13. Novel approach to management of a posterior tracheal tear complicating percutaneous tracheostomy. Madden, B.P., Sheth, A., Ho, T.B., McAnulty, G. British journal of anaesthesia. (2004) [Pubmed]
  14. In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface. Singer, I.I., Kawka, D.W., Kazazis, D.M., Clark, R.A. J. Cell Biol. (1984) [Pubmed]
  15. Enhanced expression of neural cell adhesion molecules and tenascin (cytotactin) during wound healing. Chuong, C.M., Chen, H.M. Am. J. Pathol. (1991) [Pubmed]
  16. Increased VEGF expression in the epiphyseal cartilage after ischemic necrosis of the capital femoral epiphysis. Kim, H.K., Bian, H., Randall, T., Garces, A., Gerstenfeld, L.C., Einhorn, T.A. J. Bone Miner. Res. (2004) [Pubmed]
  17. Mechanisms of ulcer healing and effects of nonsteroidal anti-inflammatory drugs. Schmassmann, A. Am. J. Med. (1998) [Pubmed]
  18. Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice. Graiani, G., Emanueli, C., Desortes, E., Van Linthout, S., Pinna, A., Figueroa, C.D., Manni, L., Madeddu, P. Diabetologia (2004) [Pubmed]
  19. Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. Chai, J., Baatar, D., Tarnawski, A. Gastroenterology (2004) [Pubmed]
  20. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. Welch, M.P., Odland, G.F., Clark, R.A. J. Cell Biol. (1990) [Pubmed]
  21. Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes. Bamberger, C., Schärer, A., Antsiferova, M., Tychsen, B., Pankow, S., Müller, M., Rülicke, T., Paus, R., Werner, S. Am. J. Pathol. (2005) [Pubmed]
  22. Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Clark, R.A., Tonnesen, M.G., Gailit, J., Cheresh, D.A. Am. J. Pathol. (1996) [Pubmed]
  23. Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair. Levine, J.H., Moses, H.L., Gold, L.I., Nanney, L.B. Am. J. Pathol. (1993) [Pubmed]
  24. Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels. Wolf, B.A., Williamson, J.R., Easom, R.A., Chang, K., Sherman, W.R., Turk, J. J. Clin. Invest. (1991) [Pubmed]
  25. Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor. Williamson, J.R., Ostrow, E., Eades, D., Chang, K., Allison, W., Kilo, C., Sherman, W.R. J. Clin. Invest. (1990) [Pubmed]
  26. The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo. Hinz, B., Gabbiani, G., Chaponnier, C. J. Cell Biol. (2002) [Pubmed]
  27. Extravascular diffusion in normal and neoplastic tissues. Nugent, L.J., Jain, R.K. Cancer Res. (1984) [Pubmed]
  28. Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. Tilton, R.G., Kawamura, T., Chang, K.C., Ido, Y., Bjercke, R.J., Stephan, C.C., Brock, T.A., Williamson, J.R. J. Clin. Invest. (1997) [Pubmed]
  29. The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice. Agah, A., Kyriakides, T.R., Lawler, J., Bornstein, P. Am. J. Pathol. (2002) [Pubmed]
  30. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. Chen, C.C., Mo, F.E., Lau, L.F. J. Biol. Chem. (2001) [Pubmed]
  31. Expression of cyclooxygenase 1 and 2 by human gastric endothelial cells. Hull, M.A., Thomson, J.L., Hawkey, C.J. Gut (1999) [Pubmed]
  32. Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin. Chen, B.K., Leiferman, K.M., Pittelkow, M.R., Overgaard, M.T., Oxvig, C., Conover, C.A. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  33. Induced expression of syndecan in healing wounds. Elenius, K., Vainio, S., Laato, M., Salmivirta, M., Thesleff, I., Jalkanen, M. J. Cell Biol. (1991) [Pubmed]
  34. Exogenous Smad3 accelerates wound healing in a rabbit dermal ulcer model. Sumiyoshi, K., Nakao, A., Setoguchi, Y., Okumura, K., Ogawa, H. J. Invest. Dermatol. (2004) [Pubmed]
  35. Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts. Desmoulière, A., Rubbia-Brandt, L., Grau, G., Gabbiani, G. Lab. Invest. (1992) [Pubmed]
  36. The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia. Bauer, S.M., Goldstein, L.J., Bauer, R.J., Chen, H., Putt, M., Velazquez, O.C. J. Vasc. Surg. (2006) [Pubmed]
  37. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Darby, I., Skalli, O., Gabbiani, G. Lab. Invest. (1990) [Pubmed]
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