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Chemical Compound Review:

MK 791 sodium(Z)-7-[(2R)-2-amino-2- carboxy...

Synonyms:

Gnarpe, H. et al., Köller, M. et al., Finlay, K.R. et al.

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Disease relevance of MK 791

The potential usefulness of MK-787 in conjunction with MK-791 in the infected eye should be examined further in an animal model of bacterial endophthalmitis [1].

High impact information on MK 791

Imipenem and the renal enzyme inhibitor MK 0791 (dehydropeptidase-I) were tested separately and in a 1:1 combination to delineate their effects on granulocyte functioning [2].
Stimulation of granulocyte functions in vitro by imipenem and the renal enzyme inhibitor MK 0791 [2].

Associations of MK 791 with other chemical compounds

The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor [3].

References

Ocular penetration of N-formimidoyl thienamycin (MK-787) and potentiation by dipeptidase inhibitor (MK-791). Finlay, K.R., Carlson, C.L., Chow, A.W. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
Stimulation of granulocyte functions in vitro by imipenem and the renal enzyme inhibitor MK 0791. Gnarpe, H., Belsheim, J., Blomqvist, C., Lundbäck, A. Antimicrob. Agents Chemother. (1984) [Pubmed]
Cilastatin (MK 0791) is a potent and specific inhibitor of the renal leukotriene D4-dipeptidase. Köller, M., Brom, J., Raulf, M., König, W. Biochem. Biophys. Res. Commun. (1985) [Pubmed]

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