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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Endophthalmitis


High impact information on Endophthalmitis


Chemical compound and disease context of Endophthalmitis


Biological context of Endophthalmitis


Anatomical context of Endophthalmitis


Gene context of Endophthalmitis

  • CONCLUSIONS: Lysostaphin is effective in treating experimental endophthalmitis mediated by MRSA [25].
  • CONCLUSION: IL-8 is thus considered to play a role in the progression of intraocular inflammation, and granulocytes are thought to be a possible source of IL-8 in endophthalmitis [26].
  • The intraocular inflammatory cell influx and retinal destruction in plcR-deficient endophthalmitis approached the severity observed in wild-ype infections, but not until 36 h postinfection [27].
  • Experimental endophthalmitis was established by the midvitreous injection of approximately 30 CFU of S. aureus RN6390 or the isogenic attenuated strains RN6911 (agr mutant), ALC136 (sar mutant), and ALC135 (agr sar double mutant) [28].
  • PURPOSE: To determine the role of complement and Fas Ligand (FasL) in the host defense against Staphylococcus aureus endophthalmitis [29].

Analytical, diagnostic and therapeutic context of Endophthalmitis


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  2. Moxifloxacin efficacy and vitreous penetration in a rabbit model of Staphylococcus aureus endophthalmitis and effect on gene expression of leucotoxins and virulence regulator factors. Bronner, S., Jehl, F., Peter, J.D., Ploy, M.C., Renault, C., Arvis, P., Monteil, H., Prevost, G. Antimicrob. Agents Chemother. (2003) [Pubmed]
  3. Treatment of experimental methicillin-resistant Staphylococcus epidermidis endophthalmitis with intravitreal vancomycin and intravitreal dexamethasone. Smith, M.A., Sorenson, J.A., D'Aversa, G., Mandelbaum, S., Udell, I., Harrison, W. J. Infect. Dis. (1997) [Pubmed]
  4. Dose response of experimental Pseudomonas endophthalmitis to ciprofloxacin, gentamicin, and imipenem: evidence for resistance to "late" treatment of infections. Davey, P.G., Barza, M., Stuart, M. J. Infect. Dis. (1987) [Pubmed]
  5. Evidence of less severe aortic valve destruction after treatment of experimental staphylococcal endocarditis with vancomycin and dexamethasone. Siaperas, P., Pefanis, A., Iliopoulos, D., Katsarolis, I., Kyroudi-Voulgari, A., Donta, I., Karayiannakos, P., Giamarellou, H. Antimicrob. Agents Chemother. (2001) [Pubmed]
  6. Povidone-iodine to prevent ophthalmia neonatorum. Petri, A.R., Pietsch, M. N. Engl. J. Med. (1995) [Pubmed]
  7. A controlled trial of povidone-iodine as prophylaxis against ophthalmia neonatorum. Isenberg, S.J., Apt, L., Wood, M. N. Engl. J. Med. (1995) [Pubmed]
  8. Prophylaxis of gonococcal and chlamydial ophthalmia neonatorum. A comparison of silver nitrate and tetracycline. Laga, M., Plummer, F.A., Piot, P., Datta, P., Namaara, W., Ndinya-Achola, J.O., Nzanze, H., Maitha, G., Ronald, A.R., Pamba, H.O. N. Engl. J. Med. (1988) [Pubmed]
  9. Single-dose therapy of gonococcal ophthalmia neonatorum with ceftriaxone. Laga, M., Naamara, W., Brunham, R.C., D'Costa, L.J., Nsanze, H., Piot, P., Kunimoto, D., Ndinya-Achola, J.O., Slaney, L., Ronald, A.R. N. Engl. J. Med. (1986) [Pubmed]
  10. Candida albicans endophthalmitis after anabolic steroid abuse. Widder, R.A., Bartz-Schmidt, K.U., Geyer, H., Brunner, R., Kirchhof, B., Donike, M., Heinmann, K. Lancet (1995) [Pubmed]
  11. Miconazole in fungal endophthalmitis. Gallo, J., Grunstein, H., Clifton-Bligh, P., Billson, F.A., Tarr, K.H. Lancet (1982) [Pubmed]
  12. Single-dose kanamycin therapy of gonococcal ophthalmia neonatorum. Fransen, L., Nsanze, H., D'Costa, L., Brunham, R.C., Ronald, A.R., Piot, P. Lancet (1984) [Pubmed]
  13. Comparison of the effects of continuous and intermittent systemic administration on the penetration of gentamicin into infected rabbit eyes. Barza, M., Kane, A., Baum, J. J. Infect. Dis. (1983) [Pubmed]
  14. Methotrexate reduces the complications of endophthalmitis resulting from intravitreal injection compared with dexamethasone in a rabbit model. Deng, S.X., Penland, S., Gupta, S., Fiscella, R., Edward, D.P., Tessler, H.H., Goldstein, D.A. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  15. A hemolysin-encoding plasmid contributes to bacterial virulence in experimental Enterococcus faecalis endophthalmitis. Stevens, S.X., Jensen, H.G., Jett, B.D., Gilmore, M.S. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  16. The effects of infection and probenecid on the transport of carbenicillin from the rabbit vitreous humor. Barza, M., Kane, A., Baum, J. Invest. Ophthalmol. Vis. Sci. (1982) [Pubmed]
  17. Gonococcal infection of the newborn in Florida, 1984-1989. Desenclos, J.C., Garrity, D., Scaggs, M., Wroten, J.E. Sexually transmitted diseases. (1992) [Pubmed]
  18. Treatment of experimental Staphylococcus epidermidis endophthalmitis with oral trovafloxacin. Ng, E.W., Samiy, N., Ruoff, K.L., Cousins, F.V., Hooper, D.C., von Gunten, S., D'Amico, D.J., Baker, A.S. Am. J. Ophthalmol. (1998) [Pubmed]
  19. Verteporfin therapy in combination with triamcinolone: published studies investigating a potential synergistic effect. Kaiser, P.K. Current medical research and opinion. (2005) [Pubmed]
  20. A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis? Fung, C.P., Chang, F.Y., Lee, S.C., Hu, B.S., Kuo, B.I., Liu, C.Y., Ho, M., Siu, L.K. Gut (2002) [Pubmed]
  21. Treatment of experimental cryptococcal meningitis and disseminated candidiasis with SCH39304. Perfect, J.R., Wright, K.A., Hobbs, M.M., Durack, D.T. Antimicrob. Agents Chemother. (1989) [Pubmed]
  22. Endophthalmitis after phakic intraocular lens implantation to correct high myopia. Pérez-Santonja, J.J., Ruíz-Moreno, J.M., de la Hoz, F., Giner-Gorriti, C., Alió, J.L. Journal of cataract and refractive surgery. (1999) [Pubmed]
  23. Childhood blindness in the context of VISION 2020--the right to sight. Gilbert, C., Foster, A. Bull. World Health Organ. (2001) [Pubmed]
  24. Efficacy and safety of gentamicin and streptomycin in Optisol-GS, a preservation medium for donor corneas. Smith, T.M., Popplewell, J., Nakamura, T., Trousdale, M.D. Cornea (1995) [Pubmed]
  25. Lysostaphin is effective in treating methicillin-resistant Staphylococcus aureus endophthalmitis in the rabbit. Dajcs, J.J., Thibodeaux, B.A., Hume, E.B., Zheng, X., Sloop, G.D., O'Callaghan, R.J. Curr. Eye Res. (2001) [Pubmed]
  26. Interleukin-8 expressed in the granulocytes of the eye in a patient with Behçet's disease complicated by lens-induced endophthalmitis. Sakamoto, H., Sakamoto, T., Kubota, T., Duan, H., Koga, T., Furue, M., Ishibashi, T. Jpn. J. Ophthalmol. (2003) [Pubmed]
  27. Relationship of plcR-regulated factors to Bacillus endophthalmitis virulence. Callegan, M.C., Kane, S.T., Cochran, D.C., Gilmore, M.S., Gominet, M., Lereclus, D. Infect. Immun. (2003) [Pubmed]
  28. Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis. Booth, M.C., Cheung, A.L., Hatter, K.L., Jett, B.D., Callegan, M.C., Gilmore, M.S. Infect. Immun. (1997) [Pubmed]
  29. Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis. Engelbert, M., Gilmore, M.S. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  30. Ocular penetration of N-formimidoyl thienamycin (MK-787) and potentiation by dipeptidase inhibitor (MK-791). Finlay, K.R., Carlson, C.L., Chow, A.W. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
  31. Use of fluconazole in the treatment of candidal endophthalmitis. Akler, M.E., Vellend, H., McNeely, D.M., Walmsley, S.L., Gold, W.L. Clin. Infect. Dis. (1995) [Pubmed]
  32. National outcomes of cataract extraction. Retinal detachment and endophthalmitis after outpatient cataract surgery. Cataract Patient Outcomes Research Team. Javitt, J.C., Street, D.A., Tielsch, J.M., Wang, Q., Kolb, M.M., Schien, O., Sommer, A., Bergner, M., Steinberg, E.P. Ophthalmology (1994) [Pubmed]
  33. Bleb-related endophthalmitis after trabeculectomy with mitomycin C. Higginbotham, E.J., Stevens, R.K., Musch, D.C., Karp, K.O., Lichter, P.R., Bergstrom, T.J., Skuta, G.L. Ophthalmology (1996) [Pubmed]
  34. Human aqueous humor levels of oral ciprofloxacin, levofloxacin, and moxifloxacin. García-Sáenz, M.C., Arias-Puente, A., Fresnadillo-Martinez, M.J., Carrasco-Font, C. Journal of cataract and refractive surgery. (2001) [Pubmed]
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