Chemical Compound Review:
CIL (Z)-2-[[(1S)-2,2- dimethylcyclopropyl]carbo...
Synonyms:
AC1L9JKX
- Imipenem/cilastatin therapy of bacteremia. Eron, L.J. Am. J. Med. (1985)
- Role of imipenem/cilastatin in the treatment of soft tissue infections. Marier, R.L. Am. J. Med. (1985)
- Factors predisposing to seizures in seriously ill infected patients receiving antibiotics: experience with imipenem/cilastatin. Calandra, G., Lydick, E., Carrigan, J., Weiss, L., Guess, H. Am. J. Med. (1988)
- Imipenem/cilastatin in the treatment of osteomyelitis. MacGregor, R.R., Gentry, L.O. Am. J. Med. (1985)
- The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem. Tune, B.M., Hsu, C.Y. J. Am. Soc. Nephrol. (1990)
- Imipenem: first of a new class of beta-lactam antibiotics. Barza, M. Ann. Intern. Med. (1985)
- Estimating Y chromosome specific microsatellite mutation frequencies using deep rooting pedigrees. Heyer, E., Puymirat, J., Dieltjes, P., Bakker, E., de Knijff, P. Hum. Mol. Genet. (1997)
- Beta-lactamase activity of purified and partially characterized human renal dipeptidase. Campbell, B.J., Forrester, L.J., Zahler, W.L., Burks, M. J. Biol. Chem. (1984)
- Results of a clinical trial of clinafloxacin versus imipenem/cilastatin for intraabdominal infections. Solomkin, J.S., Wilson, S.E., Christou, N.V., Rotstein, O.D., Dellinger, E.P., Bennion, R.S., Pak, R., Tack, K. Ann. Surg. (2001)
- Acute necrotizing pancreatitis: treatment strategy according to the status of infection. Büchler, M.W., Gloor, B., Müller, C.A., Friess, H., Seiler, C.A., Uhl, W. Ann. Surg. (2000)
- In vitro susceptibility and in vivo efficacy of antimicrobials in the treatment of Bacteroides fragilis-Escherichia coli infection in mice. Brook, I. J. Infect. Dis. (1989)
- Intravenous meropenem versus imipenem/cilastatin in the treatment of serious bacterial infections in hospitalized patients. Meropenem Serious Infection Study Group. Colardyn, F., Faulkner, K.L. J. Antimicrob. Chemother. (1996)
- A randomized multicenter trial of piperacillin/tazobactam versus imipenem/cilastatin in the treatment of severe intra-abdominal infections. Swedish Study Group. Eklund, A.E., Nord, C.E. J. Antimicrob. Chemother. (1993)
- Monotherapy in serious hospital-acquired infections: a clinical trial of ceftazidime versus imipenem/cilastatin. European Study Group. Norrby, S.R., Finch, R.G., Glauser, M. J. Antimicrob. Chemother. (1993)
- Imipenem/cilastatin: pharmacokinetic profile in renal insufficiency. Gibson, T.P., Demetriades, J.L., Bland, J.A. Am. J. Med. (1985)
- Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. Nitanai, Y., Satow, Y., Adachi, H., Tsujimoto, M. J. Mol. Biol. (2002)
- Nephrotoxicity of vancomycin and drug interaction study with cilastatin in rabbits. Toyoguchi, T., Takahashi, S., Hosoya, J., Nakagawa, Y., Watanabe, H. Antimicrob. Agents Chemother. (1997)
- Safety and efficacy of imipenem/cilastatin in treatment of complicated urinary tract infections. Cox, C.E., Corrado, M.L. Am. J. Med. (1985)
- Identification of membrane dipeptidase as a major glycosyl-phosphatidylinositol-anchored protein of the pancreatic zymogen granule membrane, and evidence for its release by phospholipase A. Hooper, N.M., Cook, S., Lainé, J., Lebel, D. Biochem. J. (1997)
- Insulin stimulates the release of the glycosyl phosphatidylinositol-anchored membrane dipeptidase from 3T3-L1 adipocytes through the action of a phospholipase C. Movahedi, S., Hooper, N.M. Biochem. J. (1997)
- Imipenem pharmacokinetics and body fluid concentrations in patients receiving high-dose treatment for serious infections. MacGregor, R.R., Gibson, G.A., Bland, J.A. Antimicrob. Agents Chemother. (1986)
- Disposition of radiolabeled imipenem and cilastatin in normal human volunteers. Norrby, S.R., Rogers, J.D., Ferber, F., Jones, K.H., Zacchei, A.G., Weidner, L.L., Demetriades, J.L., Gravallese, D.A., Hsieh, J.Y. Antimicrob. Agents Chemother. (1984)
- Effect of cilastatin on cyclosporine-induced acute nephrotoxicity in kidney transplant recipients. Carmellini, M., Frosini, F., Filipponi, F., Boggi, U., Mosca, F. Transplantation (1997)
- Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers. Standiford, H.C., Drusano, G.L., Bustamante, C.I., Rivera, G., Forrest, A., Tatem, B., Leslie, J., Moody, M. Antimicrob. Agents Chemother. (1986)
- Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase. Keynan, S., Hooper, N.M., Turner, A.J. Biochem. J. (1997)
- Meropenem versus imipenem/cilastatin in the treatment of intra-abdominal infections. Brismar, B., Malmborg, A.S., Tunevall, G., Lindgren, V., Bergman, L., Mentzing, L.O., Nyström, P.O., Anséhn, S., Bäckstrand, B., Skau, T. J. Antimicrob. Chemother. (1995)
- Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. Enomoto, A., Takeda, M., Shimoda, M., Narikawa, S., Kobayashi, Y., Kobayashi, Y., Yamamoto, T., Sekine, T., Cha, S.H., Niwa, T., Endou, H. J. Pharmacol. Exp. Ther. (2002)
- Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. COPD Study Group. Hamacher, J., Vogel, F., Lichey, J., Kohl, F.V., Diwok, K., Wendel, H., Lode, H. J. Antimicrob. Chemother. (1995)
- Pharmacokinetic profile of imipenem/cilastatin in normal volunteers. Drusano, G.L., Standiford, H.C. Am. J. Med. (1985)
- The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA. Keynan, S., Hooper, N.M., Felici, A., Amicosante, G., Turner, A.J. Antimicrob. Agents Chemother. (1995)
- Pharmacokinetics of imipenem-cilastatin in neonates. Freij, B.J., McCracken, G.H., Olsen, K.D., Threlkeld, N. Antimicrob. Agents Chemother. (1985)
- Multiple-dose study of imipenem/cilastatin in patients with end-stage renal disease undergoing long-term hemodialysis. Berman, S.J., Sugihara, J.G., Nakamura, J.M., Kawahara, K.K., Wong, E.G., Musgrave, J.E., Wong, L.M., Siemsen, A.M. Am. J. Med. (1985)
- Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. Kim, S.H., Kwon, J.W., Kim, W.B., Lee, M.G. Antimicrob. Agents Chemother. (1999)
- Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration. Tegeder, I., Bremer, F., Oelkers, R., Schobel, H., Schüttler, J., Brune, K., Geisslinger, G. Antimicrob. Agents Chemother. (1997)