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Chemical Compound Review:

Niclofolan 4-chloro-2-(5-chloro-2- hydroxy-3-nitro...

Synonyms: Niclofolano, Niclofolanum, Menichlopholan, Bilevon M, BAYER-9015, ...

Bunnag, D. et al., Choi, D.W., Vanijanonta, S. et al., Nwokolo, C. et al., Eckhardt, T. et al., et al.

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Disease relevance of Bilevon M

Treatment of human fascioliasis with niclofolan [1].
Single dose therapy of paragonimiasis with menichlopholan [2].
A clinical trial of Niclofolan on human opisthorchiasis was carried out in 60 patients admitted to the Hospital for Tropical Diseases [3].
A single dose of 2 mg/kg body weight of niclofolan yielded 100% cure rate [4].

High impact information on Bilevon M

Pharmacokinetics of niclofolan in desert sheep [5].
Various drugs have been introduced for the treatment of paragonimiasis, and among them, bithionol, niclofolan and praziquantel have shown high therapeutic efficacy [6].

Analytical, diagnostic and therapeutic context of Bilevon M

Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan [3].

References

Treatment of human fascioliasis with niclofolan. Eckhardt, T., Heckers, H. Gastroenterology (1981) [Pubmed]
Single dose therapy of paragonimiasis with menichlopholan. Nwokolo, C., Volkmer, K.J. Am. J. Trop. Med. Hyg. (1977) [Pubmed]
Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. Bunnag, D., Harinasuta, T., Desakorn, V. Southeast Asian J. Trop. Med. Public Health (1981) [Pubmed]
Paragonimus heterotremus and other Paragonimus spp. in Thailand: pathogenesis, clinic and treatment. Vanijanonta, S., Bunnag, D., Harinasuta, T. Arzneimittel-Forschung. (1984) [Pubmed]
Pharmacokinetics of niclofolan in desert sheep. Ali, B.H., el Sheikh, H.A., McKellar, Q.A. J. Vet. Pharmacol. Ther. (1990) [Pubmed]
Paragonimus and paragonimiasis in Korea. Choi, D.W. Kisaengchunghak Chapchi (1990) [Pubmed]

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