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MeSH Review


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Disease relevance of Paragonimiasis


High impact information on Paragonimiasis

  • A possible role of TARC in antigen-specific Th2-dominant responses in patients with Paragonimiasis westermani [6].
  • Immunoblot and immunocapture assays using anti-human IgE monoclonal antibody showed that the proteinase allergens were reactive with specific IgE of patients with paragonimiasis westermani [7].
  • PATIENTS: Pulmonary paragonimiasis was diagnosed in 13 patients at the Third Department of Internal Medicine, Miyazaki Medical College between 1993 and 1999 [8].
  • Thus, the cysteine protease in the ESP of PwNEM could provide a novel role to control recruitment of inflammatory cells in larval-infected lesions in human paragonimiasis [9].
  • The antibody could be readily used to prepare an affinity-purified antigen for use in an indirect ELISA that was highly sensitive and specific for the detection of circulating antibody in sera of paragonimiasis patients [10].

Chemical compound and disease context of Paragonimiasis


Biological context of Paragonimiasis


Anatomical context of Paragonimiasis


Gene context of Paragonimiasis

  • Only the 31.5 kD component was recognized by all 32 paragonimiasis sera [17].
  • There was remarkable agreement among the methods and it was concluded that the LAT could be a useful serodiagnostic technique for paragonimiasis, especially in field surveys [5].
  • We report a Laotian patient with pleural paragonimiasis who did not have the usual diagnostic triad for this parasitic disease [18].
  • Soluble CD23 and IL-5 levels in the serum and culture supernatants of peripheral blood mononuclear cells in a girl with cutaneous paragonimiasis: case report [19].
  • CONCLUSION: In addition to the two previously described paragonimiasis foci of Kupe mountain and Mundani, the identification of autochthonous cases of paragonimiasis in the peri-urban zone of Kumba town, makes the South West Province the most endemic zone of paragonimiasis in Cameroon at present [20].

Analytical, diagnostic and therapeutic context of Paragonimiasis


  1. Enzyme-linked immunosorbent assay using cysteine proteinase antigens for immunodiagnosis of human paragonimiasis. Ikeda, T., Oikawa, Y., Nishiyama, T. Am. J. Trop. Med. Hyg. (1996) [Pubmed]
  2. Evaluation of ELISA for the diagnosis of paragonimiasis westermani. Imai, J. Trans. R. Soc. Trop. Med. Hyg. (1987) [Pubmed]
  3. The identification of a Clonorchis sinensis gene encoding an antigenic egg protein. Lee, M., Chung, Y.B., Lee, S.K., Chung, B.S., Li, S., Choi, M.H., Hong, S.T. Parasitol. Res. (2005) [Pubmed]
  4. Cloning and expression of a cysteine proteinase gene from Paragonimus westermani adult worms. Kim, T.S., Na, B.K., Park, P.H., Song, K.J., Hontzeas, N., Song, C.Y. J. Parasitol. (2000) [Pubmed]
  5. Application of the latex agglutination test for human paragonimiasis in South America. Kobayashi, M., Kojima, S., Yokogawa, M., Tsuji, M., Tsubota, N. Trans. R. Soc. Trop. Med. Hyg. (1988) [Pubmed]
  6. A possible role of TARC in antigen-specific Th2-dominant responses in patients with Paragonimiasis westermani. Katoh, S., Matsumoto, N., Matsumoto, K., Tokojima, M., Ashitani, J., Nakamura-Uchiyama, F., Matsushima, K., Matsukura, S., Nawa, Y. Int. Arch. Allergy Immunol. (2004) [Pubmed]
  7. Identification and characterization of major allergens in excretory/secretory products of the worm Paragonimus ohirai. Ikeda, T. Int. Arch. Allergy Immunol. (2002) [Pubmed]
  8. Clinicoradiologic features of pleuropulmonary Paragonimus westermani on Kyusyu Island, Japan. Mukae, H., Taniguchi, H., Matsumoto, N., Iiboshi, H., Ashitani , J., Matsukura, S., Nawa, Y. Chest (2001) [Pubmed]
  9. Proteolytic activity of cysteine protease in excretory-secretory product of Paragonimus westermani newly excysted metacercariae pivotally regulates IL-8 production of human eosinophils. Shin, M.H., Lee, S.Y. Parasite Immunol. (2000) [Pubmed]
  10. Monoclonal antibodies to Paragonimus heterotremus and their potential for diagnosis of paragonimiasis. Maleewong, W., Intapan, P.M., Priammuenwai, M., Wongkham, C., Tapchaisri, P., Morakote, N., Chaicumpa, W. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  11. Successful praziquantel treatment of paragonimiasis following bithionol failure. A case report. Johnson, R.J., Dunning, S.B., Minshew, B.H., Jong, E.C. Am. J. Trop. Med. Hyg. (1983) [Pubmed]
  12. Single dose therapy of paragonimiasis with menichlopholan. Nwokolo, C., Volkmer, K.J. Am. J. Trop. Med. Hyg. (1977) [Pubmed]
  13. Treatment of human pulmonary paragonimiasis with triclabendazole: clinical tolerance and drug efficacy. Calvopiña, M., Guderian, R.H., Paredes, W., Chico, M., Cooper, P.J. Trans. R. Soc. Trop. Med. Hyg. (1998) [Pubmed]
  14. Studies on paragonimiasis: treatment with mebendazole, emetine with mebendazole and praziquantel. Benjapong, W., Naeypatimanond, S., Benjapong, K., Thumaruksa, C., Ruttarasarn, S., Jaroonvesama, N. Southeast Asian J. Trop. Med. Public Health (1984) [Pubmed]
  15. Detection of humoral immune response to Gnathostoma spinigerum in mice. Anantaphruti, M., Waikagul, J., Nithi-Uthai, S., Pubampen, S., Rojekittikhun, W. Southeast Asian J. Trop. Med. Public Health (1986) [Pubmed]
  16. Immunoglobulin E: raised levels in sera and pleural exudates of patients with paragonimiasis. Yokogawa, M., Kojima, S., Araki, K., Tomioka, H., Yoshida, S. Am. J. Trop. Med. Hyg. (1976) [Pubmed]
  17. Antigenic components of Paragonimus heterotremus recognized by infected human serum. Maleewong, W., Wongkham, C., Pariyanonda, S., Intapan, P., Pipitgool, V., Daenseegaew, W., Morakote, N. Parasite Immunol. (1991) [Pubmed]
  18. Pleural paragonimiasis in a Southeast Asia refugee. Minh, V.D., Engle, P., Greenwood, J.R., Prendergast, T.J., Salness, K., St Clair, R. Am. Rev. Respir. Dis. (1981) [Pubmed]
  19. Soluble CD23 and IL-5 levels in the serum and culture supernatants of peripheral blood mononuclear cells in a girl with cutaneous paragonimiasis: case report. Matsumoto, T., Kimura, S., Yamauchi, M., Nawa, Y., Miike, T. Annals of tropical paediatrics. (1998) [Pubmed]
  20. An epidemiological study of pleuropulmonary paragonimiasis among pupils in the peri-urban zone of Kumba town, Meme Division, Cameroon. Moyou-Somo, R., Kefie-Arrey, C., Dreyfuss, G., Dumas, M. BMC public health [electronic resource]. (2003) [Pubmed]
  21. Immunodiagnosis of human paragonimiasis by an enzyme immunoassay. Knobloch, J., Lederer, I. Tropenmedizin und Parasitologie. (1983) [Pubmed]
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